|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Perils and Pitfalls of History 显示文摘 | Fowler D | 1991 | For the Learning of Mathematics1991，11，2： | 1 |
| 3 | Effects of protein content and composition on white noodle making quality: color 显示文摘 | Wang C Kovacs M I P Fowler D B | 2004 | Cereal Chemistry2004，81，： | 1 |
| 4 | A hybrid approach using the analytic hierarchy process and integer programming to screen weapon systems projects 显示文摘 | Greiner M A Fowler J W Shunk D L | 2003 | IEEE Transactions on Engineering Management2003，50，2： | 1 |
| 5 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 6 | Flexural strength of reinforced polymer concrete made with recycled plastic waste显示文摘 | Rebeiz K S Fowler D W | 1996 | ACI structural journal1996，93，5： | 1 |
| 7 | A Threshold Model of Content Knowledge Transfer for Socioscientific Argumentation 显示文摘 | SADLER T D FOWLER S R | 2006 | Science Education2006，90，： | 1 |
| 8 | A comparison of the analgesic effects of butorphanol with those of meloxicam after elective ovariohysterectomy in dogs 显示文摘 | Caulkett N Read M Fowler D | 2003 | Can Vet J2003，44，7： | 1 |
| 9 | Canopy light environment and yield of narrow - row cotton as affected by canopy architecture显示文摘 | Reta - Sanchez D G Fowler J L | 2002 | Agrono- my Journal2002，94，： | 1 |
| 10 | Choledocholithiasis:endoscopic vers 118 laparopie management显示文摘 | Heili M J Wintz N K Fowler D L | | 0，，02： | 1 |
| 11 | Nanoscale Materials with Mesostructured Interiors显示文摘 | Fowler C E Khushalani D Lebean B | 2001 | Adv Mater2001，13，9： | 1 |
| 12 | A system for freezing biological materials显示文摘 | Gusta L V Boyachek M Fowler D B | 1978 | Hort Science1978，13，： | 1 |
| 13 | Histomorphological features of chorionic villi at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies显示文摘 | Roberts L Sebire NJ Fowler D | 2000 | Placenta2000，21，7： | 1 |
| 14 | A prominent role for the CBF cold response pathway in configuring the low-temperature metaho- lome of Arabidopsis显示文摘 | COOK D FOWLER S FIEHN O | 2004 | Proceedings of the National Academy of Sciences USA2004，101，15： | 1 |
| 15 | Developmental regula tion of low-temperature tolerance in winter wheat显示文摘 | Mahfoozi S Limin A E Fowler D B | 2001 | Annals of Botany2001，87，： | 1 |
| 16 | Bar-code technology for medication administration: medication errors and nurse sa- tisfaction显示文摘 | Fowler S B Sohler P Zarillo D F | 2009 | Medsurg Nuts2009，18，2： | 1 |
| 17 | Cambrian-Ordovician shales in the Humber Zone: Thermal maturation and source rock potential显示文摘 | Bertrand R Lavoie D Fowler M | 2003 | Bulletin of Canadian Petroleum Geology2003，51，3： | 1 |
| 18 | Advances in micrometeorological methods for the measurement and interpretation of gas and particle nitrogen fluxes显示文摘 | Fowler D Coyle M Flechard C | 2001 | Plant and Soil2001，228，： | 1 |
| 19 | Nanoscale materials with mesostructured interiors显示文摘 | Fowler C E Khushalani D Lebeau B | 2001 | Adv Mater (Weinheim Ger)2001，13，： | 1 |
| 20 | Deposition of atmospheric pollutants to the LOIS area显示文摘 | Smith R I Cape J N Binnie J Murray T D Young M and Fowler D | 1997 | Science of the Total Environment1997，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员