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| 1 | Current scenario of traditional medicines in management of diabetic foot ulcers:A review显示文摘Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often recurring.DFU have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound healing.DFU have been the leading cause for non-traumatic amputations of part or whole of the limb.Western medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading techniques.Advances in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in amputations.However,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing nations.This process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without recurrence.Wound modulation with various dressings and techniques are often a costly affair.Some aspects of the topical therapy with modern/Western medicines are frequently not addressed.Cost of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/relevance.Traditional Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood circulation.Traditional medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound healing.There is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic concerns.Various natural and plant derived products(e.g.,honey,aloe vera,oils,and calendula)and maggots are also used for wound healing purposes.We believe that patients with a chronic wound are so tired physically,emotionally,and financially that they usually accept native traditional medicine which has the same cultural base,belief,and faith.Many of these products have never been tested in accordance to“evidence-based medicine.”There are usually case reports and experience-based reports about these products.Recently,there have been some trials(in vitro and in vivo)to verify the claims of usage of traditional medicines in management of DFU.Such studies show that these natural products enhance the healing process by controlling infection,stimulating granulation tissue,antimicrobial action,promoting fibroblastic activity and collagen deposition,etc.In this review,we attempt to study and analyse the available literature on results of topical traditional medicines,which are usually advocated in the management of DFU.An integrated and‘holistic’approach of both modern and traditional medicine may be more acceptable to the patient,cost effective,and easy to administer and monitor.This may also nevertheless lead to further improvement in quality of life and decrease in the rates of amputations for DFU. | Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande | 2023 | World Journal of Diabetes2023，14，1： | 3 |
| 2 | De- functioning loop ileostomy with low anterior resection for distal rectal cancer:should we make an ileostomy as a routine procedure? A prospective randomized study显示文摘 | Chude G Rayate N Patris V Koshariya M Jagad R | 2008 | Hepatogastroenterology2008，55，8687： | 1 |
| 3 | TRAIL - engineered pancreas - de- rived mcsenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells显示文摘 | Moniri MR Sun XY Rayat J | 2012 | Cancer Gene Ther2012，6，： | 1 |
| 4 | Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches显示文摘 | Lehr EJ Rayat GR Chiu B | | 0，，04： | 1 |
| 5 | Visual function and vision-related quality of life after macular hole surgery with short-duration, 3-day face-down positioning显示文摘 | Jaspreet Rayat David R.P. Almeida Michel Belliveau Jonathan Wong Jeffrey Gale | 2011 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2011，，5： | 1 |
| 6 | Direct writing of patterned ceramics using electron-beam lithography and metallopolymer resists显示文摘 | Clendenning S B Aouba S Rayat M S | 2004 | Adv Mater2004，16，3： | 1 |
| 7 | Defunctioning loop ileostomy with low anterior resection for distal rectal cancer:should we make an ileostomy as a routine procedure? A prospective randomized study显示文摘 | Chude GG Rayate NV Patris V | | 0，，86： | 1 |
| 8 | Potential implications of mesenchymal stem cells in cancer therapy显示文摘 | Long-Jun Dai Mani R. Moniri Zhi-Rong Zeng Jeff X. Zhou Jarrett Rayat Garth L. Warnock | 2011 | Cancer Letters2011，，1： | 1 |
| 9 | Defunctioning loop ileostomy with low anterior resection for distal rectal cancer: should we make ileostomy as a routine procedure? A prospective randomized study 显示文摘 | Chude GG Rayate NV Patris V | 2008 | Hepatogastroenterology2008，55，： | 1 |
| 10 | Neonatal porcine islet cells induce human CD4^+,but not CD8^+,lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro显示文摘 | Murray AG Nelson RC Rayat GR | 1999 | Diabetes1999，48，9： | 1 |
| 11 | Microenca sulation of neonatal porcine islets: protection from human antibody complement mediated cytolysis in vitro and longterm reversal of diabetes in nude mice显示文摘 | Rayat GR Rajotte RV Ao Z | 2000 | Transplantation2000，69，6： | 1 |
| 12 | Influence of external electric field on the polarity of water droplets in water-in-oil emulsion phase transition显示文摘 | Rayat K Feyzi F | 2011 | Colloids and Surface A:Physicochemical and Engineering Aspects2011，375，1： | 1 |
| 13 | Single injection of insulin delays the recurrence of diabetes in syngenic islet-transplanted diabetic NOD mice显示文摘 | Rayat G R Singh B Korbutt G S | 2000 | Transplantation2000，70，6： | 1 |
| 14 | Defunctioning loop ileosto-my with low anterior resection for distal rectal cancer : should wemake an ileostomy as a routine procedure? A prospective randomizedstudy显示文摘 | Chude GG Rayate NV Patris V | 2008 | Hepatogastroenterology2008，55，8687： | 1 |
| 15 | Microencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice 显示文摘 | Rayat G R Rajotte R V Ao Z | 2000 | Transplantation2000，69，6： | 1 |
| 16 | Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB 显示文摘 | Rayat G R Gill R G | 2005 | Diabetes2005，54，2： | 1 |
| 17 | Correlation of proteinuria with podocyte foot process ef- facement in IgA nephropathy: An uhrastructural study显示文摘 | Rohit Tewari Ritambhra Nada Charan Singh Rayat | 2015 | Ultrastructural Pathology2015，39，2： | 1 |
| 18 | Indefinite survival of neonatal porcine islet xenografts by simuhaneous targeting of LFA-1 and CD154 or CD45RB显示文摘 | Rayat GR Gill RG | 2005 | Diabetes2005，54，2： | 1 |
| 19 | Defunctioning loop ileostomy witll low anterior resection for distal rectal cancer:should we make an ileostomy as a routine procedure?A prospective randomized study显示文摘 | Chude GG Rayate NV Patris V | 2008 | Hepatogastroentemlogy2008，55，8687： | 1 |
| 20 | In vitro and in vivo expression of Galalpha- ( 1 , 3 ) Gal on porcine islet cells is age dependent 显示文摘 | Rayat G R Rajotte R V Hering B J | 2003 | J Endocrinol2003，177，1： | 1 |
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