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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Seeing the forest or the trees : Implications of construal level theory for consumer choice 显示文摘 | Ravi D Euniee Y K | 2007 | Journal of Consumer Psychology2007，17，2： | 1 |
| 3 | Estimation of tool wear during CNC milling using neural network-based sensor fusion 显示文摘 | Ghosh N Ravi Y B Patra A | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 4 | Estimation of tool wear during CNC milling using neural network-based sensor fusion显示文摘 | GHOSH N RAVI Y B PATRA A | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 5 | A New Model Reference Adaptive Controller for Four Quadrant Vector Controlled Induction Motor Drives显示文摘 | A V Ravi Teja C Chakraborty S Maiti Y Hori | 2012 | IEEE Transactions on Industrial Elec- tronics2012，59，： | 1 |
| 6 | Clinical characteristics and treatment response in poor and good insight obsessive--com- pulsive disorder 显示文摘 | Ravi K V Samar R Janardhan R Y | 2004 | European Psychiatry2004，19，4： | 1 |
| 7 | Iterative methods for a fourth order boundary value problem显示文摘 | Agarwal Ravi P Chow Y M | 1984 | J Comput Appl Math1984，10，： | 1 |
| 8 | A case of fatal aconitine poisoning by monk shood ingestion 显示文摘 | Ravi P Lorraine Y Barry G | 2008 | J Forensic Sci2008，53，49： | 1 |
| 9 | Development of Ultra-high Molecular Weight Polyethylene (UHMWPE) Coating by Cold Spray Technique显示文摘 | RAVI K ICHIKAWA Y DEPLANCKE T | 2015 | Journal of Thermal Spray Technology2015，24，6： | 1 |
| 10 | Estimation of toolwear during CNC milling using neural network-basedsensor fusion显示文摘 | Ghosh N Ravi Y B Patra P | 2007 | Mechanical Systems and Signal Pro-cessing2007，21，1： | 1 |
| 11 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 12 | Abatement of nitrogen oxides in a catalytic reactor enhanced by nonthermal plasma discharge显示文摘 | Mok Y S Ravi V Kang H C | 2003 | IEEE Transactions on Plasma Science2003，42，3： | 1 |
| 13 | Estimation of tool wear during CNC milling using neural network- based sensor fusion显示文摘 | Ghosh N Ravi Y B Patra A | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 14 | Development and characteriza- tion of polymeric microsphere for controlled release protein loaded drug delivery system 显示文摘 | RAVI S PEH KK DARWIS Y | 2008 | Indian J Pharm Sci2008，70，3： | 1 |
| 15 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 16 | Photoluminescence properties of nanocrystalline ZnS on nanoporous silicon: A novel method of advanced materials processing 显示文摘 | MURUGAN A V HENG O H Y RAVI V VISWANATH A K SAAMINATHAN V | 2006 | Journal of Materials Science2006，41，： | 1 |
| 17 | Production planning to support mixedmodel assembly显示文摘 | FONG Y D RAVI T | 2003 | Computers & Industrial Engineering2003，45，3： | 1 |
| 18 | Modeling a low-carbon garment supply chain显示文摘 | Krishnendu S Ravi S Surendra S Y | 2012 | Production Planning & Control:The Management of Operations2012，12，： | 1 |
| 19 | Cubic spline for a class of singular two point boundary value problems显示文摘 | Ravi Kanth A S V Reddy Y N | 2005 | Comput Appl Math2005，170，： | 1 |
| 20 | Modeling a low-carbon garment supply chain 显示文摘 | KRISHNENDU S RAVI S SURENDRA Y | 2013 | Production Planning & Control2013，21，24： | 1 |
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