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| 1 | Evaluation of pedestrian mid-block road crossing behaviour using artificial neural network显示文摘Pedestrians usually cross the road at mid-block locations in India because of the ease and convenience to reach their destination as compared to intersection locations.It is important to evaluate the pedestrian gap acceptance behavior at mid-block locations because of inadequate vehicular gaps under mixed traffic condition,which translates into the pedestrian road crossing behavior.The present study examines the pedestrian gap acceptance behaviour by employing an artificial neural network(ANN) model for understanding the decision making process of pedestrians,i.e.,acceptance or rejection of vehicular gaps at a mid-block location.From the results it has been found that the pedestrian rolling gap,frequency of attempt,vehicular gap size,pedestrian speed change condition and vehicle speed have major role in pedestrian gap acceptance.These results can lead to a better design of pedestrian crossing facilities where adequate gaps are not available in vehicular flow at mid-block crosswalk locations. | B Raghuram Kadali Nivedan Rathi Vedagiri Perumal | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，2： | 13 |
| 2 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 3 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 4 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 5 | Primary hepatic amyloidosis:A case report and review ofliterature显示文摘We describe a case of 42-year-old female presenting with abdominal pain associated with loss of weight and fever for 8 mo. On evaluation she had gross hepatomegaly with raised alkaline phosphatase and raised GGT levels with normal transaminases and bilirubin. On imaging she had diffuse enlargement of liver with heterogeneous contrast uptake in liver. Her viral marker and autoimmune markers were negative. Liver biopsy depicted massive deposition of amyloid in peri-sinusoidal spaces which revealed apple green birefringence on polarizing microscopy after Congo red staining. Cardiac and renal evaluation was unremarkable. Abdominal fat pad and rectum biopsy was negative for amyloid deposit. There was no evidence of primary amyloidosis as bone marrow examination was normal. Serum and urine immunofixation electrophoresis were normal. Immunoperoxidase staining for serum amyloid associated protein for secondary amyloidosis was negative from liver biopsy. We present this rare case of primary hepatic amyloidosis and review the literature regarding varied presentations of hepatic involvement in amyloidosis. | Nikhil Sonthalia Samit Jain Sunil Pawar Vinay Zanwar Ravindra Surude Praveen M Rathi | 2016 | World Journal of Hepatology2016，8，6： | 3 |
| 6 | Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats显示文摘 | Periasamy Meenakshi Rajendran Bhuvaneshwari Muthaiyan Ahalliya Rathi Lakshmanan Thirumoorthi Dugganaboyana Chinna Guravaiah Muthedath Janardhanan Jiji Velliyur Kanniappan Gopalakrishnan | 2010 | Applied Biochemistry and Biotechnology2010，，4： | 2 |
| 7 | Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice显示文摘 | J.K Grover V Vats S.S Rathi R Dawar | 2001 | Journal of Ethnopharmacology2001，，3： | 2 |
| 8 | The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke:a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches显示文摘Neural tissue engineering,nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system(CNS)repair.It is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes,making development of CNS therapeutics challenging.Given the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society,it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury levels.Extracellular vesicles(EVs),also known as exosomes,when derived from mesenchymal stem cells,are one of the most promising approaches that have been attempted thus far,as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell transplantation.At the same time,advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur,as well as the release of biomolecules facilitating or inducing the reparative processes.This review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable hydrogels.The rationale behind this hypothesis is presented,analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the brain.This sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration occur.Finally,the importance of including nonhuman primate models in the clinical translation pipeline,as well as the added benefit of multi-modal neuroimaging analysis to establish non-invasive,in vivo,quantifiable imagingbased biomarkers for CNS repair are discussed,aiming for more effective and safe clinical translation of such regenerative therapies to humans. | Magdalini Tsintou Kyriakos Dalamagkas Tara LMoore Yogesh Rathi Marek Kubicki Douglas LRosene Nikos Makris | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 9 | Giant exophytic renal angiomyolipoma masquerading as a retroperitoneal liposarcoma: A case report and review of literature显示文摘A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass(multi visceral resection-enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma(AML) which was extending into the retroperitoneum. AML is a rare benign tumor arising most commonly from the kidney. It can sometimes present as a diagnostic challenge as it mimics a retroperitoneal liposarcoma or a fat-containing renal cell carcinomas closely. We present this case to share our experience of managing a case of giant exophytic AML which resembled retroperitoneal liposarcoma closely and resulted into an aggressive surgery. | Gopal Sharma Ayush Jain Prerit Sharma Sonal Sharma Vinita Rathi Pankaj Kumar Garg | 2018 | World Journal of Clinical Oncology2018，9，7： | 2 |
| 10 | Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine显示文摘 | Anshu Rathi Arvind Kumar Srivastava Annie Shirwaikar Ajay Kumar Singh Rawat Shanta Mehrotra | 2007 | Phytomedicine2007，，6： | 2 |
| 11 | Graft polymerization:Starch as a model substrate显示文摘 | Athawale V D Rathi S C | 1999 | J M S-Rev Macromol Chem Phys1999，39，3： | 1 |
| 12 | Exact solutions for normal depth problem显示文摘 | Swamee Prabhata K Rathie Pushpa N | 2004 | Journal of Hydraulic Research2004，42，5： | 1 |
| 13 | Exact solutions for normal depth problem 显示文摘 | Swamee P K Rathie P N | 2004 | Journal of Hydraulic Research2004，42，5： | 1 |
| 14 | Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas显示文摘 | Virmani AK Rathi A Sathyanarayana UG | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 15 | Acute lymphoblastic leukemia presenting as non-oliguric renal failure and hypertension显示文摘 | Gupta N Gupta SK Rathi S | | 0，，07： | 1 |
| 16 | Spatially regularized compressed sensing for high angular resolution diffusion imaging 显示文摘 | Michailoich O Rathi Y Dolui S | 2011 | IEEE Transactions on Medical Imaging2011，30，5： | 1 |
| 17 | Aberrant methylation duringcervical carcinogenesis显示文摘 | Virmani AK Muller C Rathi A | 2001 | Clin Cancer Res2001，7，3： | 1 |
| 18 | Aberrant methy- lation of the HIC1 promoter is a frequent event in spe- cific pediatric neoplasms显示文摘 | Rathi A Virmani AK Harada K | 2003 | Clin Cancer Res2003，9，10： | 1 |
| 19 | Aberrant methylation during cervical carcinogenesis 显示文摘 | VIRMANI AK MULLER C RATHI A | 2001 | Clin Cancer Res2001，7，3： | 1 |
| 20 | Knowledge based threading approach to model the MHC-binders to MHC class I alleles in hepatitis E virus: a clue for epitope-based vaccine design 显示文摘 | Rathi B Sarangi A Naik S | 2010 | Int J Med Informatics2010，5，2： | 1 |
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