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| 1 | Evaluation of pedestrian mid-block road crossing behaviour using artificial neural network显示文摘Pedestrians usually cross the road at mid-block locations in India because of the ease and convenience to reach their destination as compared to intersection locations.It is important to evaluate the pedestrian gap acceptance behavior at mid-block locations because of inadequate vehicular gaps under mixed traffic condition,which translates into the pedestrian road crossing behavior.The present study examines the pedestrian gap acceptance behaviour by employing an artificial neural network(ANN) model for understanding the decision making process of pedestrians,i.e.,acceptance or rejection of vehicular gaps at a mid-block location.From the results it has been found that the pedestrian rolling gap,frequency of attempt,vehicular gap size,pedestrian speed change condition and vehicle speed have major role in pedestrian gap acceptance.These results can lead to a better design of pedestrian crossing facilities where adequate gaps are not available in vehicular flow at mid-block crosswalk locations. | B Raghuram Kadali Nivedan Rathi Vedagiri Perumal | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，2： | 13 |
| 2 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 3 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 4 | Knowledge based threading approach to model the MHC-binders to MHC class I alleles in hepatitis E virus: a clue for epitope-based vaccine design 显示文摘 | Rathi B Sarangi A Naik S | 2010 | Int J Med Informatics2010，5，2： | 1 |
| 5 | N-(2-hydroxypropyl) nvethacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive propertie 显示文摘 | Rathi R C Kopeckova P Rihova B A | 1991 | Journal of Polymer Science Part A: Polymer Chemistry (S0887-624X)1991，29，13： | 1 |
| 6 | Self- assembled peptide nanoarchitectures: Applications and future aspects 显示文摘 | SHARMA P P RATHI B RODRIGUES J | 2015 | Current Topics in Medicinal Chemistry2015，15，13： | 1 |
| 7 | L-asparaginase-induced revers- ible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia显示文摘 | Rathi B Azad RK Vasudha N | 2002 | Pediatr Neurosurg2002，37，4： | 1 |
| 8 | Methotrexate treatment of ectopic pregnancy: experience at Nizwa Hospital with literature review显示文摘 | Dhar H Hamdi I Rathi B | 2011 | Oman Med J2011，26，2： | 1 |
| 9 | A study of post-cae-sarean section wound infections in a regional referral hos-pital ,oman显示文摘 | Dhar H Al-Busaidi I Rathi B | 2014 | Sultan Qaboos Univ Med J2014，14，2： | 1 |
| 10 | MR imaging and in vivo proton spectroscopy of the brain in neonates with hypoxic ischemic encephalopathy显示文摘 | G.K Malik M Pandey R Kumar S Chawla B Rathi R.K Gupta | 2002 | European Journal of Radiology2002，，： | 1 |
| 11 | L-asparaginase-induced reversi- ble posterior leukoencephalopathy syndrome in a child with acute lym- phoblastie leukemia 显示文摘 | Rathi B Azad RK Vasudha N | 2002 | Pediatr Neurosurg2002，37，4： | 1 |
| 12 | L-asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia 显示文摘 | Rathi B Azad RK Vasudha N | 2002 | Pediatr Neurosurg2002，37，4： | 1 |
| 13 | In vitro bioadhesion of carbohydrate-containing N-(2-hydroxypropyl)methacrylamide copolymers to the GI tract of guinea pigs显示文摘 | Rihova B Rathi RC Kopeckova P | 1992 | Int J Pharm1992，87，2： | 1 |
| 14 | L-asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia显示文摘 | Rathi B Azad RK Vasudha N Hissaria P Sawlani V Gupta RK | 2002 | Pediatr Neurosurg2002，37，4： | 1 |
| 15 | Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres显示文摘 | Suh H Jeong B Rathi R | 1998 | J Biomed Mater Res1998，42，2： | 1 |
| 16 | Parasympathetic over- activity: a manifestation of temporal lobe epilepsy显示文摘 | Taksande B Rathi N Kotpalliwar S | 2013 | J Neu- rosci Rural Pract2013，4，4： | 1 |
| 17 | Methotrexate treatment of ectopic pregnancy:experience at nizwa hospital with literature review显示文摘 | Dhar H Hamdi I Rathi B | 2011 | Oman Medical Journal2011，26，2： | 1 |
| 18 | Evaluation of in vitro capacitation of stallion spermatozoa显示文摘 | Rathi R Colenbrander B Bevels MM | 2001 | Biol Reprod2001，65，2： | 1 |
| 19 | Anti-inflammatory and anti-nocieptiveactivity of the water decoction desmodium gangeticum显示文摘 | Anshu Rathi RAO CV Ravishankar B | 2004 | Ethnopharmacology2004，95，： | 1 |
| 20 | Methotrexate Treatment ofEctopic Pregnancy: Experience at Nizwa Hospital withLiterature Review显示文摘 | Dhar H Haradi I Rathi B | 2011 | Oman Medical Journal2011，26，2： | 1 |
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