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| 1 | 在良性的胆汁的阻塞的 choledochoduodenostomy 的长期的结果显示文摘 AIM:To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction.METHODS:This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir,India over a period of 10 years from January 1997 to December 2007.The total number of patients who underwent choledochoduodenostomy during this period was 270.On the basis of etiology of biliary tract obstruction,patients were divided into a calculus group,an oriental cholangiohepatitis group,a benign biliary stricture group and others.Patients were followed for a variable period of 13 mo to 15 years.RESULTS:Choledochoduodenostomy(CDD) with duodenotomy was performend in four patients.CDD with removal of T-tube,CDD with left hepatic lobectomy and CDD with removal of intra biliary ruptured hydatid was performed in three patients each.In the remaining patients only CDD was performed.Immediate post operative complications were seen in 63(23%) patients,while long-term complications were seen in 28(11%) patients,which were statistically significant.Three patients died during hospitalization while four patients died in the late post-operative period.CONCLUSION:Our conclusion is that CDD is safe and produces good long term results when a permanent biliary drainage procedure is required. | Ajaz A Malik Shiraz A Rather Shams UL Bari Khursheed Alam Wani | 2012 | World Journal of Gastrointestinal Surgery2012，4，2： | 7 |
| 2 | Detection and sequencing of plasmid encoded tetracycline resistance determinants(tetA and tetB) from food-borne Bacillus cereus isolates显示文摘Objective:To investigate the detection and sequencing of plasmid encoded tetracycline resistance genes(tet A and tet B) from food-borne and standard strains of Bacillus cereus(B. cereus).Methods:PCR was carried out to detect the tetracycline resistance genes(tet A and tet B) in food-borne B.cereus strains and the amplified products were sequenced.Results:The phenotypic resistance against tetracycline was observed in 39 of the 118 food-borne isolates and two reference strains(MTCC 430 and MTCC 1307) of B.cereus.Among the phenotypically resistant isolates,tet A was detected in 36 food-borne isolates and two reference strains(MTCC 430 and MTCC 1307).whereas,tel B was detected in 12 food-bome isolates and MTCC 1307 strain. Conclusions:A close association was therefore found between phenotypic resistance against tetracycline and presence of tetracycline resistance genes.The tet A and tet B gene fragments were amplified,purified and sequenced.The gene sequences of the isolates studied herein were found similar to tetA and tetB gene sequences of other bacteria available in NCBI.The occurrence of tetA and tetB genes in B.cereus indicate the horizontal transfer of antibiotic resistance determinants from other bacteria into B.cereus.The transfer of these resistant determinants to other potentially pathogenic bacteria may be a matter of great concern. | Mudasir Ali Rather Rabinder Singh Aulakh Jatinder Paul Singh Gill Abdul Qayoom Mir Mir Nadeem Hassan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 6 |
| 3 | Portal biliopathy显示文摘Portal biliopathy refers to cholangiographic abnormalities which occur in patients with portal cavernoma. These changes occur as a result of pressure on bile ducts from bridging tortuous paracholedochal, epicholedochal and cholecystic veins. Bile duct ischemia may occur due prolonged venous pressure effect or result from insufficient blood supply. In addition, encasement of ducts may occur due fibrotic cavernoma. Majority of patients are asymptomatic. Portal biliopathy is a progressive disease and patients who have long standing disease and more severe bile duct abnormalities present with recurrent episodes of biliary pain, cholangitis and cholestasis. Serum chemistry, ultrasound with color Doppler imaging, magnetic resonance imaging with magnetic resonance cholangiopancreatography and magnetic resonance portovenography are modalities of choice for evaluation of portal biliopathy. Endoscopic retrograde cholangiography being an invasive procedure is indicated for endotherapy only. Management of portal biliopathy is done in a stepwise manner. First, endotherapy is done for dilation of biliary strictures, placement of biliary stents to facilitate drainage and removal of bile duct calculi. Next portal venous pressure is reduced by formation of surgical porto-systemic shunt or transjugular intrahepatic portosystemic shunt. This causes significant resolution of biliary changes. Patients who persist with biliary symptoms and bile duct changes may benefit from surgical biliary drainage procedures(hepaticojejunostomy or choledechoduodenostomy). | mohammad s khuroo ajaz a rather naira s khuroo mehnaaz s khuroo | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 4 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 5 | Hepatobiliary and pancreatic ascariasis显示文摘Hepatobiliary and pancreatic ascariasis(HPA) was described as a clinical entity from Kashmir,India in 1985. HPA is caused by invasion and migration of nematode,Ascaris lumbricoides,in to the biliary tract and pancreatic duct. Patients present with biliary colic,cholangitis,cholecystitis,hepatic abscesses and acute pancreatitis. Ascarides traverse the ducts repeatedly,get trapped and die,leading to formation of hepatolithiasis. HPA is ubiquitous in endemic regions and in Kashmir,one such region,HPA is the etiological factor for 36.7%,23%,14.5% and 12.5% of all biliary diseases,acute pancreatitis,liver abscesses and biliary lithiasis respectively. Ultrasonography is an excellent diagnostic tool in visualizing worms in gut lumen and ductal system. The rational treatment for HPA is to give appropriate treatment for clinical syndromes along with effective anthelmintic therapy. Endotherapy in HPA is indicated if patients continue to have symptoms on medical therapy or when worms do not move out of ductal lumen by 3 wk or die within the ducts. The worms can be removed from the ductal system in most of the patients and such patients get regression of symptoms of hepatobiliary and pancreatic disease. | Mohammad S Khuroo Ajaz A Rather Naira S Khuroo Mehnaaz S Khuroo | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 6 | Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters显示文摘Biomimetic cell culture substrates are developed as an alternative to the conventional substrates.They provide necessary biochemical and biophysical cues to the cells from their surrounding environment for their optimal growth,behaviour and physiology.Changes in physiology of cells growing on biomimetic substrate can essentially affect results of in vitro biological experiments such as drug cytotoxicity,nanoparticle internalization or signalling pathways.As majority of ECM proteins are fibrous in nature,nanofibrous scaffolds have more biomimicking properties.Therefore,in this study,we developed ECM mimicking polycaprolactone-chitosan nanofiber substrate and evaluated its effect on cell morphology,proliferation,cell cycle and ECM production.Further,cellular uptake of BSA-AuNCs has been assessed on conventional and biomimetic substrate in order to demonstrate the effect of these events on cellular properties.It was observed that the cells that were grown for 15 days on the nanofibers,had majority of cells in the proliferative phase of cell cycle compared to TCPS.Moreover,these cells showed extensive collagen and fibronectin production.Due to these conditions C3H10T1/2 cells displayed higher cell internalization of BSA-AuNCs.Overall,this study indicates that the nano-topographical and biochemical environment could alter the cell proliferative behaviour and ECM production,which affects the cell internalization of BSA-AuNCs.Also,PCL-chitosan nanofibrous substrate could be a better alternative to TCPS for cell culture studies. | Dhwani Jhala Hilal Rather Dhaval Kedaria Juhi Shah Sanjay Singh Rajesh Vasita | 2019 | Bioactive Materials2019，4，1： | 4 |
| 7 | Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application显示文摘Skin wound healing involves a coordinated cellular response to achieve complete reepithelialisation.Elevated levels of reactive oxygen species(ROS)in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing process.Cerium oxide nanoparticles(CeNPs)have the ability to protect the cells from oxidative damage by actively scavenging the ROS.Furthermore,matrices like nanofibers have also been explored for enhancing wound healing.In the current study CeNP functionalised polycaprolactone(PCL)-gelatin nanofiber(PGNPNF)mesh was fabricated by electrospinning and evaluated for its antioxidative potential.Wide angle XRD analysis of randomly oriented nanofibers revealed^2.6 times reduced crystallinity than pristine PCL which aided in rapid degradation of nanofibers and release of CeNP.However,bioactive composite made between nanoparticles and PCLgelatin maintained the fibrous morphology of PGNPNF upto 14 days.The PGNPNF mesh exhibited a superoxide dismutase(SOD)mimetic activity due to the incorporated CeNPs.The PGNPNF mesh enhanced proliferation of 3T3-L1 cells by^48%as confirmed by alamar blue assay and SEM micrographs of cells grown on the nanofibrous mesh.Furthermore,the PGNPNF mesh scavenged ROS,which was measured by relative DCF intensity and fluorescence microscopy;and subsequently increased the viability and proliferation of cells by three folds as it alleviated the oxidative stress.Overall,the results of this study suggest the potential of CeNP functionalised PCL-gelatin nanofibrous mesh for wound healing applications. | Hilal Ahmad Rather Ria Thakore Ragini Singh Dhwani Jhala Sanjay Singh Rajesh Vasita | 2018 | Bioactive Materials2018，3，2： | 4 |
| 8 | Asymptomatic Paget's disease of bone presenting with complete atrioventricular block显示文摘 | A. Rauoof Malik Nazir A. Lone Hilal A. Rather Vicar M Jan Javid A. Malik Khursheed A. Khan S. Jalal | 2008 | Chinese Medical Journal2008，，22： | 3 |
| 9 | Epidemiological profile of pediatric ocular trauma in a tertiary hospital of northern India显示文摘PurposeOcular 损伤是在孩子的获得的盲目的最普通的原因之一。它测量大约全部的童年损害的 8%-14% 。这研究试图决定在在北 India.MethodsA 回顾的学习出席一所第三级的医院的小儿科的年龄组的眼睛的损伤的流行病学的侧面在眼睛门诊病人部门与眼睛的损伤介绍的 0-16 年在我们在2014年6月之间的医院里被进行到2015年7月和所有孩子们,紧急情况被注册在里面学习。象年龄,性别分发,表示的持续时间,损害的模式,损害的类型和最后的视觉结果一样的各种各样的流行病学的参数是 analyzed.ResultsOf 总数 357 病人,(76%) 271 在 12 年的年龄下面;有眼睛的损伤的 41.1% 孩子属于年龄组 2-6 年。到女比率的男性是 2.9:1。从彻底的病人,(67.8%) 242 与关上的地球损害介绍了。在关上的地球损害之中,秋天的历史在大约 35% 孩子是在场的,当玩蝙蝠 / 球(15.7%) 和手指钉子损伤(13.2%) 时,由损伤列在后面。在开的地球损害之中,有针,刀,玻璃和钢笔的损伤是普通原因。家是损害(47.8%) 的最普通的地方,由街(17.9%) 和运动场(14.9%).ConclusionChildren 列在后面对眼睛的损伤脆弱并且需要更多的管理。锋利的目标喜欢针,刀,象酸一样的家庭化学药品应该从孩子的活动范围。 | Shazia Qayum Rashid Anjum Shagufta Rather | 2018 | Chinese Journal of Traumatology2018，21，2： | 2 |
| 10 | Evidence that putrescine acts as an ex- tracellular signal required for swarming in Proteus mirabilis 显示文摘 | Sturgill G Rather P N | 2004 | Mol Microbiol2004，51，： | 1 |
| 11 | Photoselective Netting: an Emerging Approach in Protected Agriculture显示文摘 | Shahak Y Rather K Zur N | 2009 | Aeta Hort2009，807，： | 1 |
| 12 | The chromosomal 2-N-acetyltransferase of Providencia stuartii: physiological functions and genetic regulation显示文摘 | Macinga DR Rather PN | 1994 | Front Biosci1994，，： | 1 |
| 13 | Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation:implications for cancer therapeutics显示文摘 | Rather MI Nagashri MN Swamy SS | | 0，，1： | 1 |
| 14 | Genetic analysis of surfacemotility in Acinetobacter baumannii显示文摘 | Clemmer KM Bonomo RA Rather PN | 2011 | Microniology2011，157，9： | 1 |
| 15 | Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis显示文摘 | Rather PH Wingertzahn MA van Bavel JH | 2006 | J Allergy Clin Immunol2006，118，5： | 1 |
| 16 | Acate myocardial infarction in the elderly:Differences by age显示文摘 | Mehta RH Rather SS Radford MJ | 2001 | J Am Coll Cardiol2001，38，8： | 1 |
| 17 | Syntheses and characterization of starch poly (metha acrylic) graft copolymer显示文摘 | ATHAWALE V D RATHER S C | 1997 | Science1997，66，11： | 1 |
| 18 | Muhidrug resistance transporters and modulation 显示文摘 | Tan B Piwnica-Worms D Rather L | 2000 | Curr Opin Onco12000，12，5： | 1 |
| 19 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3Mono) : a randomized, 52-week, phase III, double-blind,parallel-treatment trial 显示文摘 | Garber A Henry R Rather R | 2009 | J Lancet2009，373，9662： | 1 |
| 20 | C4d staining of perioperative renal transplant biopsies显示文摘 | Haas M Rather LE Montgomery RA | 2002 | Transplantation2002，74，5： | 1 |
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