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| 1 | Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth显示文摘AIM: To investigate the functional significance of insulin-like growth factor binding protein-5 (IGFBP-5) overexpression in pancreatic cancer (PaC).METHODS: The effects of IGFBP-5 on cell growth were assessed by stable transfection of BxPC-3 and PANC-1 cell lines and measuring cell number and DNA synthesis. Alterations in the cell cycle were assessed by flow cytometry and immunoblot analyses. Changes in cell survival and signal transduction were evaluated after mitogen activated protein kinase and phosphatidylinositol 3-kinase (PI3K) inhibitor treatment.RESULTS: After serum deprivation, IGFBP-5 expression increased both cell number and DNA synthesis in BxPC-3 cells, but reduced cell number in PANC-1 cells. Consistent with this observation, cell cycle analysis of IGFBP-5-expressing cells revealed accelerated cell cycle progression in BxPC-3 and G2/M arrest of PANC-1 cells. Signal transduction analysis revealed that Akt activation was increased in BxPC-3, but reduced in PANC-1 cells that express IGFBP-5. Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5. When MEK1/2 was blocked, Akt activation remained elevated in IGFBP-5 expressing PaC cells; however, inhibition of PI3K or MEK1/2 abrogated IGFBP-5-mediated cell survival.CONCLUSION: These results indicate that IGFBP-5 expression affects the cell cycle and survival signal pathways and thus it may be an important mediator of PaC cell growth. | Sarah K Johnson Randy S Haun | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 2 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 3 | Microbial manipulation as primary therapy for Crohn's disease显示文摘While antimicrobials are clinically effective in preventing post-operative recurrence,the role for antibiotics in primary therapy for Crohn's disease(CD) remains unclear.The recent multicenter phase 2 trial by Prantera et al received wide attention because it demonstrated an increase in the week 12 remission rate in patients with moderately active CD treated with rifaximin and renewed interest in microbial manipulation as primary therapy for CD.In this commentary,we discuss aspects of durability,immune cell polarization,and safety of microbial manipulation as primary therapy for CD. | Randy S Longman Arun Swaminath | 2013 | World Journal of Gastroenterology2013，19，10： | 2 |
| 4 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 5 | Poly(divinylenzene)microspheres as an Intermediate morphology between microgel,macrogel,and coagulum in cross linking precipitation polymerization显示文摘 | Jeffrey S D Geoff Melsaac Randy S F | 2001 | Macromolecules2001，34，： | 1 |
| 6 | Stock Market Liquidity and the Business Cycle 显示文摘 | Randi N S Johannes A Skjehorp Bernt Ame Degaard | 2011 | The Journal of Finance2011，，1： | 1 |
| 7 | Subsurface damage in some single crystalline optical materials显示文摘 | RANDI J A LAMBROPOULOS J C JACOBS S D | 2005 | Applied Optics2005，44，12： | 1 |
| 8 | Sex ratio and the infectionprocess in entomopathogenic nematodes :are males the colonizir^sex显示文摘 | Robin J S Moeen A H Randy G | 1998 | Journal of Invertebrate Pathology1998，72，： | 1 |
| 9 | Application of Kalman Filtering to the calibration and alignment of inertial navigation systems显示文摘 | Mohinder S G Vinson D H Randy S M | 1991 | IEEE Transactions on Automatic Control1991，36，1： | 1 |
| 10 | Hexachlorobenzene increases ornithine decarboxylase activity,free polyamines content and c-Myc,c-Fos and c-Jun protein levels in rat liver显示文摘 | Randi A S Hernandez S | 2003 | Toxicology Letters2003，144，1： | 1 |
| 11 | Evaluationof shock absorber models显示文摘 | STEFAAN D RANDY S KOENRAAD R | 1997 | Vehicle SystemDynamics1997，27，2： | 1 |
| 12 | Exploring process data with the use of robust outlier detection algorithms显示文摘 | LEO H C RANDY J P MARY B S | 2003 | Journal of Process Control2003，，13： | 1 |
| 13 | Biomass to ethanol: A holistic approach using gasification-fermenta- tion显示文摘 | Lewis R S Randy S H Raymond L | 2004 | Abstracts of Papers American Chemical Society2004，227，1： | 1 |
| 14 | Epidemiology of sepsis:Anupdata显示文摘 | Angus Derek C Randy S | 2001 | Critical care medicine2001，29，： | 1 |
| 15 | Subsurface damage in some single crystalline optical materials显示文摘 | J A Randi J C Lambropoulos S D Jacobs | 2005 | Appl Opt2005，44，12： | 1 |
| 16 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 17 | Hexachlorobenzene increases ornithine decarboxylase activity,free polyamines content and c-Myc,c-Fos and c-Jun protein levels in rat liver显示文摘 | Randi A S Hernandez S | | 0，，01： | 1 |
| 18 | Long-term changes in intraocular pressure after clear corneal phacoemulsification: Normal patients versus glaucoma suspect and glaucoma patients显示文摘 | Bradford J Shingleton Lisa S Gamell Mark W O'Donoghue Susan L Baylus Randy King | 1999 | Journal of Cataract & Refractive Surgery1999，，7： | 1 |
| 19 | EEG patterns and epileptic seizures in acute phase stroke显示文摘 | Mecarelli O Pro S Randi F | 2011 | Cerebrovasc Dis2011，31，2： | 1 |
| 20 | Identification and analysis of gene families from the duplicated genome of soybean using EST sequences显示文摘 | Nelson R T Randy S | 2006 | BMC Genomics2006，7，： | 1 |
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