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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The inhibit of epidural morphine -inducepruitus by epidural droperidol 显示文摘 | Horta ML Ramos L Goncalves ZR | 2000 | Anesth analg2000，90，3： | 1 |
| 3 | Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | 2011 | Cancer Discov2011，1，1： | 1 |
| 4 | Mutations in the DDR2 ki-nase gene identify a novel therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | | 0，，： | 1 |
| 5 | Mutations in the DDR2 kinase gene identify a nove! therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | 2011 | Cancer Discov2011，1，1： | 1 |
| 6 | Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | 2011 | Cancer Discov2011，1，1： | 1 |
| 7 | Comparison of daptomycin,vancomycin,and ampicillin-gentamicin for treatment of experimental endocarditis caused by penicillin-resistant enterococci显示文摘 | Ramos MC Grayson ML Eliopoulos GM | 1992 | Antimicrob Agents Chemother1992，36，9： | 1 |
| 8 | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells:evaluation by the comet assay 显示文摘 | Ramos AA Lima CF Pereira ML | 2008 | Toxicol Lett2008，177，1： | 1 |
| 9 | The cross talk between thyroid hormones and the Renin Angiote - ns in System 显示文摘 | Barreto Chaves ML Carrillo Seplveda MA Carneiro Ramos MS | 2010 | Vascul Pharma- col2010，52，34： | 1 |
| 10 | The inhibition of epidur-al morphine-induced pruritus by epidural droperidol显示文摘 | Horta ML Ramos L Goncalves ZR | 2000 | Anesth Analg2000，90，3： | 1 |
| 11 | Genotoxic effect in autoimmune diseases evaluated by the micronucleus test assay: our experience and literature review 显示文摘 | Torres-Bugarin O Macriz Romero N Ramos Ibarra ML | 2015 | Biomed ResInt2015，2015，19： | 1 |
| 12 | Thl and Th17 hypercytokinemia as early host response signature in severe pandemic influenza 显示文摘 | Bermejo-Martin JF Ortiz de Lejarazu R Pumarola T Rello J Almansa R Ramirez P Martin-Loeches I Varillas D Gallegos MC Seran C Micheloud D Gomez JM Tenorio-Abreu A Ramos MJ Molina ML Huidobro S Sanchez E Gorden M Fernandez V del Castillo A Marcos MA Villanueva B Lopez C J Rodriguez-Dominguez M Galan JC Canton R Lietor A Rojo S Eiros JM Hinojosa C Gonzalez I Torner N Banner D Leon A Cuesta P Rowe T Kelvin DJ | 2009 | Crit Care2009，13，6： | 1 |
| 13 | The inhibition of epidural morphine-induced pruritus by epidural droperidol显示文摘 | Horta ML Ramos L Goncalves IR | 2000 | Anesth Analg2000，90，2： | 1 |
| 14 | Comparison of daptomycin,vancomycin,and ampicillin-gentamicin for treatment of experimental endocarditis caused by penicillin-resistant enterococci显示文摘 | Ramos MC Grayson ML Eliopoulos GM | 1992 | Antimicrob Agents Chemother1992，36，： | 1 |
| 15 | NMR study of the complexation of D-galactonic acid with tungsten ( VI ) and molybdenum ( VI ) 显示文摘 | Ramos ML Caldeira MM Gil VMS | 1997 | Carbohydrate Research1997，297，3： | 1 |
| 16 | Inhibition of epidural morphine-induced pruitus by intravenous droperidol: the effect of increasing the doses of morphine and of droperidol显示文摘 | Horta ML Ramos L Goncalves IR | 1996 | Reg Anesth1996，21，4： | 1 |
| 17 | Biperiden(M1antagonist)impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization显示文摘 | Ramos AC Andersen ML Oliveira MG Soeiro AC Galduróz JC | 2012 | Behav Brain Res2012，231，1： | 1 |
| 18 | NMR Study of uronic acids and their complexation with molybdenum ( V1 ) and tungsten ( V1 ) oxoions显示文摘 | Ramos ML Caldeira MM Gil VMS | 1996 | Carbohydrate Research1996，286，5： | 1 |
| 19 | Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | 2011 | Cancer Discov2011，1，1： | 1 |
| 20 | Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer显示文摘 | Hammerman PS Sos ML Ramos AH | 2011 | Cancer Discov2011，1，1： | 1 |
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