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| 1 | Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays显示文摘AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as 'cases'. Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as 'controls'. Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ2 P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in 'cases' vs 'controls' for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials. | Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 2 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Mustafa S. Ascha Ibrahim A. Hanouneh Rocio Lopez Tarek Abu‐Rajab Tamimi Ariel F. Feldstein Nizar N. Zein | 2010 | Hepatology2010，，6： | 4 |
| 3 | 基于图像处理的个性化建模:从医学扫描到高精度计算模型的转换(英文)显示文摘目的对于生物力学领域的研究者来说,计算仿真技术已成为一种不可或缺的工具。对于这种工具的性能,至关重要的一点在于其有效模拟个性化问题方面的能力。本文将阐述能将三维数字图像(由CT、超声机或MRI扫描仪生成的)直接转换生成高精度计算模型的一种独特的非常有效的方法。方法采用的方法主要涉及:基于扫描的数据生成可输出到商业网格器中的表面模型——这种方法非常费时并且不是很精确,事实上对于复杂拓扑结构的影像数据这种方法很难处理:另外一种更加直接的方法是将几何模型的生成和网格划分一次性完成——这种方法先对感兴趣区域(三维图像分割)进行识别分割,然历直接生成基于一种由定义的边界分割的体素的体网格,这种方法被用来在整个体模型生成四面体和/或六面体单元,从而直接划分网格。结果采用一种基于图像的网格方法来处理问题是非常先进的,也是非常精确有效的。这种基于图像自动生成的网格,其有限元单元模型区域边界正好在等值面上因此其考虑了局部体效应从而能保证局部体素的精确度。结论对影像数据进行网格化是挑战也是机遇,这种与以往方法思想不一样的方法,在很多例子中,获得了更好的结果。这种能简易生成精确模型的方法,对于当前很多数值分析难以处理的问题诸如血液流体和病人个性化假体设计等提供了新的解决方案。 | XIA Ling Rajab Said Philippe Young Gavin Tabor Sam Coward HUANG Jean | 2008 | 医用生物力学2008，23，1： | 4 |
| 4 | Enucleation and evisceration: indications, complications and clinicopathological correlations显示文摘·AIM: To assess main indications, postoperative complications and clinicopathological correlation of ocular enucleation-evisceration.·METHODS: A total of 107 subjects who underwent enucleation and/or evisceration and received hydroxyapatite implants(Scleral wrap or mesh) were assessed. For each patient clinicopathological data was collected which included demographic information,clinical history, primary clinical diagnosis, main cause of ophthalmic surgery(traumatic, non-traumatic), type of surgical procedure(enucleation, evisceration) and pathological report. Patients' postoperative clinical visits were checked for procedure-related complications during first year after surgery.·RESULTS: One hundred and seven patients(male:65.4%; mean age: 26y) underwent enucleation(n=100) or evisceration(n =7) due to traumatic(n =41) and non-traumatic(n =66) causes. Disfiguring painful blind eye was the most common indication of surgery(66.4%),followed by leukocoria(19.6%) and endophthalmitis(4.7%). The main types of injury included firecracker,traffic and work accidents, and sharp object perforating injury. In 53(80.3%) subjects in non-traumatic group the initial clinical diagnosis matched the histopathologicalresults. Malignant tumors(retinoblastoma: 47.5%,malignant melanoma: 27.3%) were the most common pathological diagnoses followed by phthisis bulbi(25.8%).The most common procedure-related complications were major eye discharge(39.6%), and implant exposure and discharge(20.8%).·CONCLUSION: Trauma and malignant tumors are the leading causes of enucleation-evisceration. Despite developing new techniques and materials, enucleation is still associated with considerable postoperative complications. | Ali Kord Valeshabad Masood Naseripour Rajab Asghari Seyed Hamid Parhizgar Seyed Ehsan Parhizgar Mohammad Taghvaei Shahin Miri | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 4 |
| 5 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 6 | 利比亚的农业前景及水资源显示文摘与世界上许多干旱、半干旱地区相似,利比亚的农业用水主要依赖于地下水层。利比亚的有些具有最好的农业用地的地区,其地下水超采严重,超过自然补给率的500%,由此引起地下水水位每年下降很多,沿海地区的海水倒灌。本文提出了一些水资源管理的措施,包括调水、减少灌溉面积、海水淡化及一些辅助措施。如不对国家有限的水资源严加管理,子孙后代将面临严峻的水危机。 | Rajab M.El Asswad 陈建耀 | 1995 | 人类环境杂志1995，24，6： | 2 |
| 7 | 用PDE-5抑制剂治疗勃起功能障碍的男性患者中前列腺癌的发生率:回顾性研究显示文摘本研究比较了用PDE-5抑制剂治疗勃起功能障碍(ED)7年的男性患者和与这些患者年龄及各种风险因素相似的7年内不使用PDE一5抑制剂治疗ED的男性患者中前列腺癌发生率的情况。通过分析2000年到2006年的电子病例和数据库,以年龄在50至69岁,2000年前无前列腺癌病史的ED患者作为研究对象。这些患者被分为两组:2362名曾用PDE-5抑制剂治疗的男性和2612名不曾使用过该药物的男性。比较每组的人口数据。在研究期内:97名(4.1%)接受过PDE-5抑制剂治疗的ED患者被诊断出患了前列腺癌,在非PDE-5抑制剂治疗组中,258名(9.9%)被诊断出患了前列腺癌(P〈O.0001)。在非洲裔美国人中,接受PDE-5抑制剂治疗的比例比不用的比例高(10.5%VS.7.1%,P〈0.0001)。接受过PDE-5治疗的患者,其前列腺特异性抗原增高的比例比较低(10.0%vs.13.1%,P=0.0008),但良性前列腺增生的比例比较高(38.4%vs.35.1%,P=0.0149)。接受PDE-5抑制剂治疗ED的男性不易患前列腺癌(调整后的优势比为0.4,95%CI:0.3—0.5,P〈0.0001)。我们的研究数据表明:用PDE-5抑制剂治疗ED的男性倾向于不易患前列腺癌。还需要进行更多的研究。 | Anthony H Chavez K Scott Coffield M Hasan Rajab Chanhee Joe | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 8 | Vibrational characteristics of cracked shafts 显示文摘 | Rajab M D Sabeeh A A | 1991 | Journal of Sound and Vibration1991，147，3： | 1 |
| 9 | Use of SSR data to determine relationships and potential heterotic groupings within mediumto late maturing Iranian maize inbred lines显示文摘 | Rajab C | 2006 | Field Crops Research2006，95，： | 1 |
| 10 | Small cell neuroendocrine carcinoma of the endometrium,a rare aggressive tumor 显示文摘 | Rajab KE Sandhu AK Malik A | 2005 | Saudi Med J2005，26，7： | 1 |
| 11 | Comparison between utility substation and imitative earthing system when subjected under lightning response显示文摘 | Mohamad N N Abdullah S Rajab R | 2012 | Electrical Power and Energy Systems2012，43，1： | 1 |
| 12 | Application of region-based segmentation and neural network edge detection to skin lesions显示文摘 | M.I. Rajab M.S. Woolfson S.P. Morgan | 2003 | Computerized Medical Imaging and Graphics2003，，1： | 1 |
| 13 | Back pain from spinal tuberculosis显示文摘 | Rajab TK Barre LJ | 2008 | J Am Coll Surg2008，207，3： | 1 |
| 14 | Supernumerary teeth : review of the litera- ture and a survey of 152 cases 显示文摘 | Rajab LD Hamdan MA | 2002 | Paediatr Dent2002，12，4： | 1 |
| 15 | Antimycobacterial activity of (E)-phytol and derivatives:a preliminary structure-activity study显示文摘 | Mohamed S Rajab Charles L Cantrell Scott G Franzblau | 1998 | Planta Med1998，，64： | 1 |
| 16 | Plant-parasitic nematodes associated with Musa in Zanzibar显示文摘 | Rajab K A Salim S S Speijer P R | 1999 | African Plant Protection1999，5，2： | 1 |
| 17 | Combining multiple regression and principal component analysis for accurate predictions for column ozone in Peninsular Malaysia显示文摘 | RAJAB J M MATJAFRI M Z LIM H S | 2013 | Atmospheric Environment2013，71，： | 1 |
| 18 | Vibrational characteristics of cracked shafts显示文摘 | Rajab M D Al-Sabeeh A | 1991 | Journal of Sound and Vibration1991，147，3： | 1 |
| 19 | Proximal nerve conduction studies in chronic inflammatory demyelinating polyneuropathy显示文摘 | Rajabally YA Jacob S | 2006 | Clin Neurophysiol2006，117，9： | 1 |
| 20 | Impairment of bac terial flora in human ulcerative colitis and experimental colitis in the rat显示文摘 | Fabia R Ar'Rajab A Johansson ML | 1993 | Digestion1993，54，4： | 1 |
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