|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment显示文摘Early childhood caries(ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora. Therefore, the protein composition of saliva can be a sensitive indicator for dental health. Resistance or susceptibility to caries may be significantly correlated with alterations in salivary protein components. Some oral microorganisms and saliva proteins may serve as useful biomarkers in predicting the risk and prognosis of caries. Current research has generated abundant information that contributes to a better understanding of the roles of microorganisms and salivary proteins in ECC occurrence and prevention. This review summarizes the microorganisms that cause caries and tooth-protective salivary proteins with their potential as functional biomarkers for ECC risk assessment. The identification of biomarkers for children at high risk of ECC is not only critical for early diagnosis but also important for preventing and treating the disease. | abdullah s hemadi rui-jie huang yuan zhou jing zou | 2017 | International Journal of Oral Science2017，9，4： | 18 |
| 3 | Kinetic adsorption of application of carbon nanotubes for Pb(Ⅱ) removal from aqueous solution显示文摘The capability of carbon nanotubes (CNTs) to adsorb lead (Pb) in aqueous solution was investigated. Batch mode adsorption experiment was conducted to determine the effects of pH, agitation speed, CNTs dosage and contact time. The removal of Pb(Ⅱ) reached maximum value 85% or 83% at pH 5 or 40 mg/L of CNTs, respectively. Higher correlation coeffcients from Langmuir isotherm model indicates the strong adsorptions of Pb(Ⅱ) on the surface of CNTs (adsorption capacity Xm = 102.04 mg/g). The results indicates that the highest percentage removal of Pb (96.03%) can be achieved at pH 5, 40 mg/L of CNTs, contact time 80 min, and agitation speed 50 r/min. | Nassereldeen A Kabbashi Muataz A Atieh Abdullah Al-Mamun Mohamed E S Mirghami MD Z Alam Noorahayu Yahya | 2009 | Journal of Environmental Sciences2009，21，4： | 15 |
| 4 | 介孔载体嫁接的离子液体催化二氧化碳合成碳酸丙烯酯显示文摘将离子液体1-丙基(三乙氧基硅基)-3-甲基咪唑的氢氧化物([Smim]OH)分别嫁接到介孔SiO_2、MCM-41和SBA-15分子筛上制备了非均相嫁接型离子液体,用傅里叶变换红外光谱、N_2吸附、元素分析和热重分析等技术对3种非均相嫁接型离子液体进行了表征。在无溶剂、温和的条件下,以非均相嫁接型离子液体为催化剂,研究了环氧丙烷(PO)与CO_2环加成合成碳酸丙烯酯的反应。实验结果表明,3种非均相嫁接型离子液体均具有较好的催化性能,[Smim]OH/SiO_2的催化性能最好;在[Smim]OH/SiO_2 1.260 mmol、PO 70 mmol、CO_22 MPa、120℃、8 h的优化反应条件下,PO的转化率可达99.5%;[Smim]OH/SiO_2重复使用4次后仍能保持较高的催化性能。 | 张学兰 Abdullah S N Al-Arifi Taieb Aouak Zeid Abdullah Al-Othman 魏伟 孙予罕 | 2009 | 石油化工2009，38，12： | 8 |
| 5 | 台州、大理农村5岁以下儿童家庭二手烟暴露情况与影响因素分析显示文摘目的了解台州、大理农村地区5岁以下儿童家庭二手烟的暴露情况并探索其影响因素,为制定减少儿童家庭二手烟暴露的干预措施提供科学依据。方法2018年4-6月期间采用多阶段随机抽样的方法,对台州与大理所属农村地区与5岁以下儿童共同居住的吸烟者进行一对一问卷调查,最终获得658份有效问卷。结果与吸烟者共同居住的农村儿童家庭二手烟暴露率为59.4%;多因素分析显示,与无吸烟规定相比,家庭室内完全禁止吸烟(OR=0.62,95%CI:0.39~0.99)可降低儿童家庭二手烟暴露风险;吸烟者年龄在30岁以下(OR=3.74,95%CI:1.99~7.04)、家庭月收入3000元以下(OR=1.91,95%CI:1.33~2.73)、吸烟者对尼古丁的依赖在中度及以上时(OR=2.06,95%CI:1.46~2.92)可增加儿童家庭二手烟暴露风险;此外,其他家人吸烟(OR=1.53,95%CI:1.09~2.15)与访客吸烟(OR=1.75,95%CI:1.19~2.58)也可使儿童家庭二手烟暴露风险增加。结论台州、大理农村地区5岁以下儿童家庭二手烟暴露情况较严重,帮助吸烟者戒烟、建立家庭室内吸烟规定是保护儿童免遭家庭二手烟暴露的有效手段。 | 何静怡 郑频频 潘姿娴 陈潇潇 肖霞 郝伟 林海江 Abu S Abdullah | 2021 | 中国健康教育2021，37，3： | 4 |
| 6 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 7 | Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal stem cells and collagen membrane with and without using tricalcium phosphate: an in vivo microcomputed tomographic and histologic e显示文摘The aim of the present real time in vivo micro-computed tomography(m CT)and histologic experiment was to assess the efficacy of guided bone regeneration(GBR)around standardized calvarial critical size defects(CSD)using bone marrow-derived mesenchymal stem cells(BMSCs),and collagen membrane(CM)with and without tricalcium phosphate(TCP)graft material.In the calvaria of nine female Sprague-Dawley rats,full-thickness CSD(diameter 4.6 mm)were created under general anesthesia.Treatment-wise,rats were divided into three groups.In group 1,CSD was covered with a resorbable CM;in group 2,BMSCs were filled in CSD and covered with CM;and in group 3,TCP soaked in BMSCs was placed in CSD and covered with CM.All defects were closed using resorbable sutures.Bone volume and bone mineral density of newly formed bone(NFB)and remaining TCP particles and rate of new bone formation was determined at baseline,2,4,6,and 10 weeks using in vivo m CT.At the 10th week,the rats were killed and calvarial segments were assessed histologically.The results showed that the hardness of NFB was similar to that of the native bone in groups 1 and 2 as compared to the NFB in group 3.Likewise,values for the modulus of elasticity were also significantly higher in group 3 compared to groups 1 and 2.This suggests that TCP when used in combination with BMSCs and without CM was unable to form bone of significant strength that could possibly provide mechanical'lock'between the natural bone and NFB.The use of BMSCs as adjuncts to conventional GBR initiated new bone formation as early as 2 weeks of treatment compared to when GBR is attempted without adjunct BMSC therapy. | Khalid Al-Hezaimi Sundar Ramalingam Mansour Al-Askar Aws S ArRejaie Nasser Nooh Fawad Jawad Abdullah Aldahmash Muhammad Atteya Cun-Yu Wang | 2016 | International Journal of Oral Science2016，8，1： | 2 |
| 8 | Comparison between utility substation and imitative earthing system when subjected under lightning response显示文摘 | Mohamad N N Abdullah S Rajab R | 2012 | Electrical Power and Energy Systems2012，43，1： | 1 |
| 9 | Artificial neural network for forecasting residential electrical energy显示文摘 | Abdullah A S | 1999 | International Journal of Energy Research1999，23，8： | 1 |
| 10 | Lipoprotein(a), tissue plasminogen activator and plasrninogen activator inhibitor-1 levels in hyperlipidemic patients in kuwait显示文摘 | Akanji AO Abdullah A Tahzeeb S | 1997 | Eur J Clin Invest1997，27，5： | 1 |
| 11 | Microbial Colonisation and degradation of some fibrous crop residues in the rumen of goats显示文摘 | Ho Y Abdullah N Jalaludin S | 1996 | Asian Australasian Journal of animal sciences1996，9，： | 1 |
| 12 | The dieta- ry protein requirement of the Malaysian mahseer, Tor tambroides (Bleeker), and the lack of protein-sparing action by dietary lipid 显示文摘 | NG W K ABDULLAH N DE SILVA S S | 2008 | Aquaculture2008，284，1234： | 1 |
| 13 | Melorheostosis of the hand affecting the c6 sclerotome and presenting with carpal tunnel syndrome显示文摘 | Abdullah S Mat NN Mohamed HN | 2014 | Singapore Med J2014，55，4： | 1 |
| 14 | The effect of copper on demineralization of dental enamel 显示文摘 | Abdullah AZ Stratford SM Brookes S J | 2006 | J Dent Res2006，85，11： | 1 |
| 15 | Floating roof storage tank boilover 显示文摘 | Shaluf I M Abdullah S A | 2011 | Journal of Loss Prevention in the Process Industries2011，24，： | 1 |
| 16 | Nonlinear great deluge algorithm for rough set attribute reduction显示文摘 | JADDI N S ABDULLAH S | 2013 | Journal of Information Science and Engineering2013，29，1： | 1 |
| 17 | Analysis of cold flow fluidization test results for various biomass fuels显示文摘 | Abdullah M Z Husain Z Yin Pong S L | 2003 | Biomass and Bioenergy2003，24，6： | 1 |
| 18 | Molecular charaemrization of a new 1-deoxy-D- xylulose 5-phosphate reductoisomerase (DXR) transcript from Vanda Mimi Palmer显示文摘 | CHAN W S ABDULLAH J O NAMASIVAYAM P | 2009 | Scientia Horticulture2009，121，： | 1 |
| 19 | Effects of Laciobacil- lus cultures on growth performance,abdominal fat deposition,se- rum lipids and weight of organs of broiler chickens显示文摘 | Kalavathy R Abdullah N Jalaludin S el al | 2003 | British poultry sciences2003，，： | 1 |
| 20 | Thyroid-stimulating hormone and cyclic AMP activate p38 mitogenactivated protein kinase cascade:involvement of protein kinase A,rac1,and reactive oxygen species显示文摘 | POMERANCE M ABDULLAH H B KAMERJI S | 2000 | J Biol Chem2000，275，40： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员