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| 1 | Testing the robustness of particle-based separation models for the magnetic separation of a complex skarn ore显示文摘Physical separation processes are best understood in terms of the behaviour of individual ore particles.Yet,while different empirical particle-based separation modelling approaches have been developed,their predictive performance has never been tested under variable process conditions.Here,we investigated the predictive performance of a state-of-the-art particle-based separation model under variable feed composition for a laboratory-scale magnetic separation of a skarn ore.Two scenarios were investigated:one in which the mass flow of the different processing streams could be measured and one in which it had to be estimated from data.In both scenarios,the predictive models were sufficiently general to predict the process outcomes of new samples of variable composition.Nevertheless,the scenario in which mass flow could be measured was4%more precise in predicting mass balances.The process behaviour of minerals present at concentrations above 0.1%by weight could be accurately predicted.Our findings indicate the potential use of this method to minimize the costs of metallurgical testwork while providing in-depth understanding of the recovery behaviour of individual ore particles.Moreover,the method may be used to establish powerful tools to forecast mineral recoveries for partly new ore types at a running mining operation. | Lucas Pereira Max Frenzel Markus Buchmann Marius Kern Raimon Tolosana-Delgado K.Gerald van den Boogaart Jens Gutzmer | 2022 | International Journal of Mining Science and Technology2022，32，3： | 3 |
| 2 | Indicator Kriging without Order Relation Violations显示文摘 | Raimon Tolosana-Delgado Vera Pawlowsky-Glahn Juan-Jose Egozcue | 2008 | Mathematical Geosciences2008，，3： | 1 |
| 3 | Mechanism of HCl oxidation (deacon process) over RuO2显示文摘 | N U'RIA L JORDI G S RAIMON P M | 2008 | Journal of Catalysis2008，255，1： | 1 |
| 4 | Mechanism of HCl oxidation ( Deacon process) over RuO2 显示文摘 | Núria L Jordi G S Raimon P | 2008 | Journal of Catalysis2008，255，1： | 1 |
| 5 | Mechanism of HCl oxidation (Deacon process) over RuO 2显示文摘 | Núria López Jordi Gómez-Segura Raimon P. Marín Javier Pérez-Ramírez | 2008 | Journal of Catalysis2008，，1： | 1 |
| 6 | Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes显示文摘 | Gemma Aragonès Raimon Ferré Iolanda Lázaro Anna Cabré Núria Plana Jordi Merino Mercedes Heras Josefa Girona Lluís Masana | 2010 | Atherosclerosis2010，，1： | 1 |
| 7 | Categories of indoor environmental quality and building energy demand for heating and cooling显示文摘 | CORGNATI S P FABRIZIO E RAIMONED D | 2011 | Building Simulation2011，4，2： | 1 |
| 8 | Comparative study on the fatty acid composition of two marine vertebrates: striped dolphins and loggerhead turtles显示文摘 | Raimon G Albert M S Xavier G | 1999 | Comparative biochemistry and physiology part B1999，124，： | 1 |
| 9 | ALK和ROS1:肺癌治疗的联合靶点显示文摘间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因重排可见于包括非小细胞肺癌(non small cell lung cancer,NSCLC)在内的多种恶性肿瘤中。ALK融合基因使激酶具有异常活性,而野生型ALK激酶域突变也可使它被激活。ALK基因重排使得NSCLC中出现了新的分子亚型,该亚型对ALK抑制剂高度耐药。克唑替尼(crizotinib)是一个口服小分子ATP模拟化合物,它最初作为MET抑制剂被开发,随后被发现具有抗ALK活性的脱靶效应(off target),并被美国FDA批准用于治疗ALK阳性的NSCLC患者。近来在NSCLC患者中还发现了ROS1受体酪氨酸激酶染色体重排,而克唑替尼正处于治疗该分子亚型NSCLC患者的临床试验中。任何计算机辅助药物设计都是依赖其分子结构和配体的药物设计方法,每种方法的详细信息中均应重点强调利用这二者,以开发多靶点小分子激酶抑制剂。此类多靶点小分子激酶抑制剂均可对ROS1和ALK重排的NSCLC有抑制增殖作用。因此,本综述重点强调了关于靶向这些激酶的重要性,以及在优化出效能更佳、选择性更强的ROS1和ALK激酶抑制剂中所取得的进步。 | Raimon Puig de la Bellacasa Niki Karachaliou Roger Estrada-Tejedor Jordi Teixidó Carlota Costa José I.Borrell 吴冠楠(译) 宋勇(审校) | 2014 | 临床与病理杂志2014，34，1： | 0 |
| 10 | Phosphorylation-driven aggregative proteins in neurodegenerative diseases:implications and therapeutics显示文摘Protein aggregation is related to a large number of neurodegenerative disorders.Particularly in some cases,aggregation is induced by hyperphosphorylation of a given protein.This is the case of tau,TAR DNA-binding protein 43(TDP-43),amyloid-beta peptides(Aβ)and alpha-synuclein(α-syn),which play a key pathogenic role in Alzheimer’s disease(AD),Parkinson’s disease(PD)and amyotrophic lateral sclerosis,among others(Tenreiro et al.,2014;Chiti and Dobson,2017).In this perspective,we will discuss both the relationship between phosphorylation and amyloid aggregation as well as current and future therapeutic strategies aimed at inhibiting specific kinases involved in the phosphorylation step or inhibiting subsequent protein aggregation. | Alba Espargaró Raimon Sabate | 2024 | Neural Regeneration Research2024，19，5： | 0 |
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