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| 1 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 2 | Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia显示文摘 | Rajasingh J Raikwar HP Muthian G | 2006 | Biochem Biophys Res Commun2006，340，2： | 1 |
| 3 | Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia显示文摘 | Rajasingh J Raikwar H P Muthian G | 2006 | Biochem Biophys Res Commun2006，340，2： | 1 |
| 4 | Human i PS cellderived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice显示文摘 | RAIKWAR S P KIM E M SIVITZ W I | 2015 | PLo S One2015，10，01： | 1 |
| 5 | 1,25 Dihydroxyvitamin - D3 modulates JAK - STAT pathway in IL - 12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis显示文摘 | Muthian G Raikwar H P Rajasingh J | 2006 | J Neurosci Res2006，83，7： | 1 |
| 6 | COX-2 in- hibitors modulate IL-12 signaling through JAK-STAT pathway leading to Thl response in experimental allergic encephalomyelitis显示文摘 | Muthian G Raikwar HP Johnson C | 2006 | J Clin Immunol2006，26，1： | 1 |
| 7 | Residues inmilk and production performance of goats following the intake of apesticide (endosulfan) 显示文摘 | NAG S K MAHANTA S K RAIKWAR M K | 2007 | Small Ruminant Research2007，67，2： | 1 |
| 8 | Glucose and insulin regulate gly- colsyl phosphatidyl inositol - specific phospholipase D expression in islet beta cells显示文摘 | Bowen RF Raikwar NS Olson LK | 2001 | Metabolism2001，50，12： | 1 |
| 9 | Current status of anti-angiogenesis therapy for prostate cancer显示文摘 | Jimenez JA Kao C Raikwar S | 2006 | Urol Oncol2006，24，3： | 1 |
| 10 | Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia显示文摘 | Rajasingh J Raikwar HP Muthian G | 2006 | Biochem Biophys Res Commun2006，340，： | 1 |
| 11 | Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2:enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model显示文摘 | Raikwar SP Temm CJ Raikwar NS Kao C Molitoris BA Gardner TA | 2005 | Mol Ther2005，12，6： | 1 |
| 12 | Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet beta cells显示文摘 | Bowen RF Raikwar NS Olson LK | 2001 | Metabolism2001，50，12： | 1 |
| 13 | 1, 25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Thl response in ex- perimental allergic encephalomyelitis 显示文摘 | Muthian G Raikwar H P Rajasingh J | 2006 | J Neurosci Res2006，83，7： | 1 |
| 14 | Adenoviral vectors spressing human endostatin-angiostatin and soluble Tie2:enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model显示文摘 | Raikwar SP Temm CJ Raikwar NS | | 0，，06： | 1 |
| 15 | Medporin maxillofacial deformities:report of three cases显示文摘 | Andrade NN Raikwar K | 2009 | J Oral Maxilllofac Surg2009，8，2： | 1 |
| 16 | choline as a PET biomarker for assessment of prostate cancer tumor models显示文摘 | ZHENG Q H GARDNER T A RAIKWAR S | 2004 | Bioorg Med Chem2004，12，11： | 1 |
| 17 | Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK–STAT pathway in T cell leukemia显示文摘 | Johnson Rajasingh Himanshu P. Raikwar Gladson Muthian Caroline Johnson John J. Bright | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 18 | COX-2 inhibitors modulale IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis显示文摘 | Muthian G Raikwar HP Johnson C | 2006 | J Clin Immunol2006，26，1： | 1 |
| 19 | Strategies for developing therapeutic application of human embryonic stem cells显示文摘 | Raikwar S P Mueller T Zavazava N | 2006 | Physiology ( Bethesda)2006，21，： | 1 |
| 20 | PPAR gamma antagonists reverse the inhibition of neural antigen-specific Thl response and experi- mental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Dehal2, 14-prostaglandin J2 显示文摘 | Raikwar HP Muthian G Rajasingh J | 2006 | J Neuroimmunot2006，178，12： | 1 |
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