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| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Angew Chem lnt Ed 显示文摘 | Guldi D M Rahman G M A Prato M | 2005 | 44(13): 20152005，44，13： | 1 |
| 4 | Identification of novel cellular targets in biliary tract cancers using global gene expression technology显示文摘 | ANSEL D E RAHMAN A HIDALGO M | 2003 | Am J Pathol2003，163，： | 1 |
| 5 | Nonlinear Control of Interior Permanent-magnet Synchronous Motor显示文摘 | Rahman M A Vilathgamuwa D M Uddin M N | 2003 | IEEE Trans on Industry Applications2003，39，2： | 1 |
| 6 | A Multiscale Retinex for Bridging the Gap Between Color Images and the Human Observation of Scenes显示文摘 | Jobson D J Rahman Z Woodell G A | 1997 | IEEE Transactions on Image Processing1997，6，7： | 1 |
| 7 | Flexible bronehoseopic management of benign tracheal stenosis: long term follow-up of 115 patients显示文摘 | Rahman NA Fruebter O Shitrit D | 2010 | J Cardiot horac Surg2010，5，： | 1 |
| 8 | A multiscale retinex for bridging the gap between color images and显示文摘 | Jobson D J Rahman z Woodell G A | | 0，，7： | 1 |
| 9 | Indoor Positioning by LED Visible Light Communication and Image Sensors显示文摘 | Rahman M S Haque M M Kim K D | 2011 | Inter-national Journal of Electrical and Computer Engineering(IJECE)2011，1，2： | 1 |
| 10 | Polybrominated diphenyl ether (PBDE) flame retardants显示文摘 | Frank Rahman Katherine H Langford Mark D Scrimshaw John N Lester | 2001 | Science of the Total Environment2001，，1： | 1 |
| 11 | Properties and Performance of a Center/Surround Retinex显示文摘 | JOBSON D J RAHMAN Z WOODELL G A | 1997 | IEEE Transactions on Image Processing1997，6，3： | 1 |
| 12 | Combined penile placation surgery and insertion of penile prosthesis for severe penile curvature and erectile dysfunction显示文摘 | Rahman N U Carrion R E Bochinski D | 2004 | J Urol2004，171，： | 1 |
| 13 | Properties and Performance of a Center/Surround Retinex显示文摘 | JOBSON D J RAHMAN Z WOODELL G A | 1997 | Image Processing1997，6，3： | 1 |
| 14 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 15 | Properties and performance of a center/surround Retinex显示文摘 | Jobson D J Rahman Z Woodell G A | 1997 | IEEE Transactions on Image Processing1997，6，3： | 1 |
| 16 | Inhibitory effects of low concentration electrolyzed water and other sanitizers against foodborne pathogens on oyster mushroom显示文摘 | DING T RAHMAN S OH D | 2011 | Food Control2011，22，2： | 1 |
| 17 | Whole plant photosyn- thesis,development,and carbon partitioning in potato as a func- tion of temperature 显示文摘 | Timlin D Rahman SML Baker J | 2006 | Agronomy Journal2006，98，5： | 1 |
| 18 | Multiwavelength Brillouin/erbium ytterbium fiber laser显示文摘 | HARUN S W EMAMI S D RAHMAN F A | 2007 | Laser Physics Letters2007，4，8： | 1 |
| 19 | Microbial contamination of preservative free eye drops in multiple application containers显示文摘 | Rahman MQ Tejwani D Wilson JA | 2006 | Br J Ophthalmol2006，90，2： | 1 |
| 20 | A complex arrangement of genes at a starch branching enzyme Ⅰlocus in the D-genome donor of wheat显示文摘 | Rahman S Abrahams S Abbott D | 1997 | Genome1997，40，： | 1 |
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