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| 1 | Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats显示文摘AIM:To evaluate the therapeutic effects of a probiotic supplement(Clostridium butyricum,CGMCC0313)in a chemically-induced rat model of experimental colitis. METHODS:An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups.The positive control group was sacrificed 3 d after colitis onset.The remaining groups were fed daily with either 2 mL of C.butyricum(2.3×1011 CFU/L), 2 mL of mesalamine(100 g/L),or 1 mL of sodium butyrate(50 mmol/L)for 21 d.The animals’body weight, behavior,and bowel movements were recorded weekly. After sacrifice,visual and microscopic observations of pathological changes of colon tissue were made,body weight and wet colon mass index were measured and recorded,and serum levels of interleukin-23(IL-23) and TNF-αwere measured using ELISA.Expression of calcitonin gene-related peptide in colon tissue was measured by RT-PCR.Finally,changes in rat intestinal microflora status were measured in all groups. RESULTS:We found that treatment with C.butyricum lowered the serum levels of both IL-23 and tumor necrosis factor-α(TNF-α)with similar or even better efficiency than that of mesalamine or sodium butyrate. The rat intestinal flora appeared to recover more quickly in the group treated with C.butyricum than in the mesalamine and sodium butyrate groups.Finally,we found that the expression level of calcitonin gene related peptide was elevated in colon tissue in the sodium butyrate treated group but not in the C.butyricum or mesalamine treated groups,indicating a sensitization of colon following sodium butyrate treatment.CONCLUSION:In our experimental colitis model, treatment with C.butyricum CGMCC0313,a probiotic supplement,is at least as efficient as treatment with mesalamine. | Hai-Qiang Zhang Tomas T Ding Jun-Sheng Zhao Xin Yang Hai-Xia Zhang Juan-Juan Zhang Yun-Long Cui | 2009 | World Journal of Gastroenterology2009，15，15： | 19 |
| 2 | Stand structure and height-diameter relationship of a degraded Populus euphratica forest in the lower reaches of the Tarim River, Northwest China显示文摘Understanding stand structure and height-diameter relationship of trees provides very useful information to establish appropriate countermeasures for sustainable management of endangered forests. Populus euphratica, a dominant tree species along the Tarim River watershed, plays an irreplaceable role in the sustainable development of regional ecology, economy and society. However, as the result of climate changes and human activities, the natural riparian ecosystems within the whole river basin were degraded enormously, particularly in the lower reaches of the river where about 320 km of the riparian forests were either highly degraded or dead. In this study, we presented one of the main criteria for the assessment of vitality of P. euphratica forests by estimating the defoliation level, and analyzed forest structure and determined the height-diameter(height means the height of a tree and diameter means the diameter at breast height(DBH) of a tree) relationship of trees in different vitality classes(i.e. healthy, good, medium, senesced, dying, dead and fallen). Trees classified as healthy and good accounted for approximately 40% of all sample trees, while slightly and highly degraded trees took up nearly 60% of total sample trees. The values of TH(tree height) and DBH ranged from 0–19 m and 0–125 cm, respectively. Trees more than 15 m in TH and 60 cm in DBH appeared sporadically. Trees in different vitality classes had different distribution patterns. Healthy trees were mainly composed more of relatively younger trees than of degraded tress. The height-diameter relationships differed greatly among tress in different vitality classes, with the coefficients ranging from 0.1653 to 0.6942. Correlation coefficients of TH and DBH in healthy and good trees were higher than those in trees of other vitality classes. The correlation between TH and DBH decreased with the decline of tree vitality. Our results suggested that it might be able to differentiate degraded P. euphratica trees from healthy trees by determining the height-diameter correlation coefficient, and the coefficient would be a new parameter for detecting degradation and assessing sustainable management of floodplain forests in arid regions. In addition, tree vitality should be taken into account to make an accurate height-diameter model for tree height prediction. | AISHAN Tayierjiang HALIK ümüt Florian BETZ TIYIP Tashpolat DING Jianli NUERMAIMAITI Yiliyasijiang | 2015 | Journal of Arid Land2015，7，4： | 10 |
| 3 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 4 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 5 | Characteristics of alpha-synucleinopathy in centenarians显示文摘 | Ding ZT Wang Y Jiang YP Hashizume Y Yoshida M Mimuro M Inagaki T Iwase T | 2006 | 中国生物学文摘2006，20，8： | 4 |
| 6 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 7 | Single machine scheduling with deadlines and increasing rates of processing times显示文摘 | Cheng T C E Ding Q | 2000 | Acta Informatica2000，36，910： | 2 |
| 8 | Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in China显示文摘To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy cohorts.Cohort 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014.Area under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and models.Linear regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P<0.05).[-2]proPSA(p2PSA)was significantly correlated with PV in Cohort 2(P<0.001)but not in Cohort 1(P=0.309),while no significant association was observed between phi and PV.When combining phi with PV,phi density(PHID)and another phi derivative(PHIV,calculated as phi/PV°5)did not outperform phi for predicting PCa or clinically significant PCa in either Cohort 1 or Cohort 2.Logistic regression analysis also showed that phi and PV were independent predictors for both PCa and clinically significant PCa(all P<0.05);however,PV did not provide additional predictive value to phi when combining these derivatives in a regression model(all models vs phi were not statistically significant,all P>0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa. | Da Huang Yi-Shuo Wu Ding-Wei Ye Jun Qi Fang Liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng Xu Rong Na Jian-Feng Xu Ying-Hao Sun | 2020 | Asian Journal of Andrology2020，22，5： | 2 |
| 9 | Theoretical study of BexZn1-xO alloys显示文摘 | Ding S F Fan G H Li S T | 2007 | Physiea B2007，394，： | 1 |
| 10 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 11 | Role of PKC in the novel synergistic action of urotensin Ⅱ and angiotensin Ⅱ and in urotensin Ⅱ-induced vasoconstriction显示文摘 | Ding YJ Zhu YZ Shi Y Yao T Zhu YC | 2007 | Am J Physiol Heart Circ Physiol2007，292，1： | 1 |
| 12 | Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women显示文摘 | Ding Q F Hayashi T Zhang X J | 2007 | J Diabetes Complications2007，21，5： | 1 |
| 13 | Converting ceria polyhedral nanoparticles into single-crystal nanospheres 显示文摘 | Feng X D Sayle D C Wang Z L Paras M S Santora B Sutorik A C Sayle T X T Yang Y Ding Y Wang X D Her Y S | 2006 | Science2006，312，5779： | 1 |
| 14 | Prevalence of antibody against hepatitis E virus in variousspecies of non-human primates:evidence of widespread infection in Japanese monkeys(Macaca fuscata)显示文摘 | Hirano M Ding X Tran H T | 2003 | Jpn J Infect2003，56，： | 1 |
| 15 | Multi-crack Interaction in Limestone Subject to Stress and Flow of Chemical Solutions显示文摘 | Feng X T Ding W X Zhang D X | 2009 | International Journal of Rock Mechanics and Mining Sciences2009，46，1： | 1 |
| 16 | Wind-blown origin of the Pliocene red clay formation in the central Loess Plateau 显示文摘 | Ding Z L Sun J M Liu T S Zhu R X Yang S L Guo B | 1998 | Earth and Planetary Science Letters1998，161，： | 1 |
| 17 | Predictive value of the area of expanded cumulus mass on development of porcine oocyte maturation and fertilized in vitro 显示文摘 | QIAN Y SHI W Q DING J T | 2003 | J Reprod Dev2003，49，2： | 1 |
| 18 | A Solvothermal Elemental -direct-reaction Route to Ⅱ-Ⅵ semiconductor Nanocrystalline ZnSe and CclSe显示文摘 | LI Y D DING Y QIAN Y T | 1998 | Inorg Chem1998，37，2： | 1 |
| 19 | 显示文摘 | Kong H Z Wee A T S Ding J | 2004 | International Journal of Nanoscience2004，3，45： | 1 |
| 20 | Detection of non-contiguous ofdm symbols for cognitive radio systems without out-of- band spectrum synchronization显示文摘 | Qu D Ding J Jiang T | | IEEE Transactions on Wireless Communications0，10，2： | 1 |
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