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| 1 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 2 | Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastom显示文摘 | Raffaghello L Prigione I Airoldi I | 2004 | Neoplasia2004，6，5： | 1 |
| 3 | Downregulation and / or release of NKG2D ligands as immune evasion strategy of human neuroblastoma显示文摘 | Raffaghello L Prigione I Airoldi I | 2004 | Neoplasia2004，6，5： | 1 |
| 4 | Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens 显示文摘 | Morandi F Raffaghello L Bianchi G | 2008 | Stem Cells2008，26，5： | 1 |
| 5 | Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma 显示文摘 | Raffaghello L Prigione I Airoldi I | 2004 | Neoplasia2004，6，5： | 1 |
| 6 | Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens显示文摘 | Morandi F Raffaghello L Bianchi C | 2008 | Stem Cells2008，26，5： | 1 |
| 7 | Expression andfunctional analysis of human leukocyte antigen classⅠantigen-processing machinery in medulloblastoma显示文摘 | Raffaghello L Nozza P Morandi F | 2007 | Can-cer Res2007，67，11： | 1 |
| 8 | Human mesenchymal stem cell inhibit neutrophil apoptosis:a model for neutrophil preservation in the bone marrow niche显示文摘 | Raffaghello L Bianchi G Bertolotto M | 2008 | Stem Cells2008，26，1： | 1 |
| 9 | Human mesenchymal stem cells inhibit neutrophil apoptosis:A model for neutrophilpreservation in the bone marrow niche显示文摘 | Raffaghello L Bianchi G Bertolotto M | 2008 | Stem Cells2008，26，1： | 1 |
| 10 | Expression of P2X7 Receptor Increases In Vivo Tumor Growth显示文摘 | Elena Adinolfi Lizzia Raffaghello Anna Lisa Giuliani Luigi Cavazzini Marina Capece Paola Chiozzi Giovanna Bianchi Guido Kroemer Vito Pistoia Francesco Di Virgilio | 2012 | Cancer Research2012，，： | 1 |
| 11 | Chemokines in neuroectodermal mmour progression and metastasis 显示文摘 | Raffaghello L Cocco C Valeria M | | Semin Cancer Biol0，19，： | 1 |
| 12 | Mechanisms of immuneevasion of human neuroblastoma显示文摘 | RAFFAGHELLO L PRIGIONE I AIROLDI I | 2005 | Cancer Letters2005，228，12： | 1 |
| 13 | Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy显示文摘 | Lee C Raffaghello L Brandhorst S | 2012 | Sci Transl Med2012，4，124： | 1 |
| 14 | Immunological mechanisms in opsoclonus-myoclonus associated neuroblastoma 显示文摘 | Raffaghello L Conte M de Grandis E | 2009 | Eur J Paediatr Neurol2009，13，： | 1 |
| 15 | Role of BAFF in opsoclonus-myoclonus syndrome, a bridge between cancer and autoimmunity显示文摘 | Raffaghello L Fuhlhuber V Bianchi G | 2013 | J Leukoc Bio12013，94，： | 1 |
| 16 | Immunosup- pressive cells and turnout microenvironment, focus on mesenchy- mal stem cells and myeloid derived suppressor cells 显示文摘 | Bianchi G Borgonovo G Pistoia V Raffaghello L | 2011 | HistolHistopathol2011，26，7： | 1 |
| 17 | Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma显示文摘 | Raffaghello L Prigione I Airoldi I | 2004 | Neoplasia2004，6，5： | 1 |
| 18 | Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma显示文摘 | Raffaghello L Prigione I Airoldi I | 2004 | Neoplasia2004，6，5： | 1 |
| 19 | Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma显示文摘 | Raffaghello L Prigione I Airoidi I | 2004 | Neoplasia2004，6，5： | 1 |
| 20 | Human mesenchymal stem cells inhibit neutrophil apoptosis:a model for neutrophil preservation in the bone marrow niche显示文摘 | Raffaghello L Bianchi G Bertolotto M | | 0，，： | 1 |
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