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| 1 | Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers显示文摘AIM: To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, 'Pimpinella anisum L.' on experimentally-induced gastric ulceration and secretion in rats. METHODS: Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorus- ligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS: Anise significantly inhibited gastric mu- cosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH and gastric wall mucus concentration. CONCLUSION: Anise aqueous suspension possesses significant cytoprotective and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect of anise is possibly prostaglandin-mediated and/orthrough its anti-secretory and antioxidative properties. | Ibrahim A Al Mofleh Abdulqader A Alhaider Jaber S Mossa Mohammed O Al-Soohaibani Syed Rafatullah | 2007 | World Journal of Gastroenterology2007，13，7： | 7 |
| 2 | Adsorption of methylene blue on low-cost adsorbents: A review显示文摘 | Mohd. Rafatullah Othman Sulaiman Rokiah Hashim Anees Ahmad | 2009 | Journal of Hazardous Materials2009，，1： | 3 |
| 3 | Adsorption of methylene blue on low-cost adsorbents: a review 显示文摘 | RAFATULLAH M SULAIMAN O HASHIM R | 2010 | Journal of Hazardous Materials2010，，177： | 1 |
| 4 | Scavenging behaviour of meranti sawdust in the removal of methylene blue from aqueous solution 显示文摘 | Ahmad A Rafatullah M Sulaiman M | 2009 | Journal of Hazardous Materials2009，170，1： | 1 |
| 5 | Adsorption of methylene blue on low-cost adsorbents: A review显示文摘 | Mohd. Rafatullah Othman Sulaiman Rokiah Hashim Anees Ahmad | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 6 | Adsorption of Methylene Blue on Low-Cost Adsorbents:A Review显示文摘 | RAFATULLAH M SULAIMAN 0 HASHIM R | 2010 | Journal of Hazardous Materials2010，177，123： | 1 |
| 7 | Protective effect of Swertia chirata against indomethacin and other ulcerogenieagent induced gastric ulcers 显示文摘 | Rafatullah S Tafiq M Mossa J S | 1983 | Drugs Under Eper Clin Res1983，19，2： | 1 |
| 8 | Removal of Cu( II ) and Pb( II ) ions from aqueous solutions by adsorption on sawdust of meranti wood 显示文摘 | Ahmad A Rafatullah M Sulaiman O Ibrahim M Chii Y Siddique B | 2009 | Desalination2009，247，1： | 1 |
| 9 | 显示文摘 | Rafatullah M Sulaiman O Hashim R | 2010 | Journal of Haz ardous Materials2010，177，： | 1 |
| 10 | Rocket “Eruca sativa”:A salad herb with potential gastric anti-ulcer activity显示文摘AIM:To validate gastric anti-ulcer properties of Rocket 'Eruca sativa' on experimentally-induced gastric secretion and ulceration in albino rats.METHODS: Gastric acid secretion studies were undertaken using pylorus-ligated rats. Gastric lesions in the rats were induced by noxious chemicals including ethanol, strong alkalis, indomethacin and hypothermic restraint stress. The levels of gastric wall mucus (GWM), nonprotein sulfhydryls (NP-SH) and malondialdehyde (MDA) were also measured in the glandular stomach of rats following ethanol administration. The gastric tissue was also examined histologically. The extract was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS: In pylorus-ligated Shay rats, the ethanolic extract of Rocket 'Eruca sativa L.' (EER) signifcantly and dose-dependently reduced the basal gastric acid secretion, titratable acidity and ruminal ulceration. Rocket extract significantly attenuated gastric ulceration induced by necrotizing agents (80% ethanol, 0.2 mol/L NaOH, 25% NaCl), indomethacin and hypothermic restraint stress. The anti-ulcer effect was further confirmed histologically. On the other hand, the extract signifi cantly replenished GWM and NP-SH levels, as well as the MDA level signifi cantly reduced by extract pretreatment.CONCLUSION: Rocket extract possesses anti-secretory, cytoprotective, and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect is possibly through prostaglandin-mediated activity and/or through its anti-secretory and antioxidant properties. | Saleh Alqasoumi Mohammed Al-Sohaibani Tawfeq Al-Howiriny Mohammed Al-Yahya Syed Rafatullah | 2009 | World Journal of Gastroenterology2009，15，16： | 1 |
| 11 | Adsorption of methylene blue on low-cost adsorbents:A review显示文摘 | Mohd Rafatullah Othman Sulaiman Rokiah Hashim | | 0，，： | 1 |
| 12 | Bvaluation of turmeric(Curcuma longa)for gastric and duodenal antiulcer activity in rats显示文摘 | Rafatullah S Tariq M Yahya MA | 1990 | J Ethnopharmacol1990，29，1： | 1 |
| 13 | The use of date palm as a potential adsorbent for wastewater treatment:A review 显示文摘 | Ahmad T Danish M Rafatullah M | 2012 | Environmental Science and Pollution Re- search2012，19，5： | 1 |
| 14 | Adsorption of methylene blue on low-cost adsorbents: A review显示文摘 | RAFATULLAH M SULAIMAN O HASHIM R | 2010 | J Hazard Mater2010，177，13： | 1 |
| 15 | J Hazard Mater 显示文摘 | Rafatullah M Sulaiman O Hashim R | 2010 | 177(1/2/3): 70-802010，177，123： | 1 |
| 16 | Protective effect of Swertia chirayita against indomethacin and other ulcerogenic agent-introduced gastric ulcers显示文摘 | Rafatullah S Tariq M Mossa JS | 1993 | Drugs Exp Clin res1993，19，2： | 1 |
| 17 | Removal of Cu ( ]I ) and Pb ( lI ) ions from aqueous solutions by adsorption onto sawdust of meranti wood 显示文摘 | Ahmad A Rafatullah M Sulaiman O | 2009 | Desalination2009，247，： | 1 |
| 18 | Adsorption of methy-lene blue on low-cost adsorbents:A review 显示文摘 | RAFATULLAH M SULAIMAN O HASHIM R | 2010 | Journal of Hazardous Materials2010，177，123： | 1 |
| 19 | Titanium-based nanocomposite materials: a review of recent advances and perspec- tives显示文摘 | SHAHADAT M TENG TT RAFATULLAH M et a/ | 2015 | Colloid Surface B2015，126，： | 1 |
| 20 | Adsorption of methylene blue on low-cost adsorbents:a review显示文摘 | Rafatullah M Sulaiman O Hashim R | 2010 | Journal of Hazardous Materials2010，177，13： | 1 |
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