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| 1 | Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis显示文摘AIM:To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI) imaging as a noninvasive method for the assessment of liver fibrosis in chronic hepatitis C (CHC) patients.METHODS:We performed a prospective blind com-parison of ARFI elastography,APRI index and FibroMax in a consecutive series of patients who underwent liver biopsy for CHC in University Hospital Bucharest. His-topathological staging of liver fibrosis according to the METAVIR scoring system served as the reference. A to-tal of 74 patients underwent ARFI elastography,APRI index,FibroMax and successful liver biopsy. RESULTS:The noninvasive tests had a good correlation with the liver biopsy results. The most powerful test in predicting fibrosis was ARFI elastography. The diagnostic accuracy of ARFI elastography,expressedas area under receiver operating characteristic curve (AUROC) had a validity of 90.2% (95% CI AUROC = 0.831-0.972,P < 0.001) for the diagnosis of significant f ibrosis (F ≥ 2). ARFI sonoelastography predicted even better F3 or F4 fibrosis (AUROC = 0.993,95% CI = 0.979-1).CONCLUSION:ARFI elastography had very good accuracy for the assessment of liver fibrosis and was superior to other noninvasive methods (APRI Index,FibroMax) for staging liver fibrosis. | Carmen Fierbinteanu-Braticevici Dan Andronescu Radu Usvat Dragos Cretoiu Cristian Baicus Gabriela Marinoschi | 2009 | World Journal of Gastroenterology2009，15，44： | 114 |
| 2 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 3 | 工商业与人权的关键议题及其在新时代的意义——以联合国工商业与人权指导原则为中心显示文摘联合国工商业与人权指导原则是工商业与人权领域综合性的指导方针。由于其谨慎的制订过程,在相关软法体系中的核心地位,及其内容创新、语言简洁、涵盖面广等特点,有很高的权威性。联合国工商业与人权指导原则所确立的工商业与人权领域的关键议题包括企业尊重人权的责任、供应链的职责、获得救济的方式、国家的作用、人权尽职调查、环境问题等。工商业与人权在中国特色社会主义进入了新时代的历史阶段,具有非同一般的意义。 | Radu Mares 张万洪 | 2018 | 西南政法大学学报2018，20，2： | 18 |
| 4 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 5 | New targeted therapies in pancreatic cancer显示文摘Patients with pancreatic cancer have a poor prognosis with a median survival of 4-6 mo and a 5-year survival of less than 5%. Despite therapy with gemcitabine, patient survival does not exceed 6 mo, likely due to natural resistance to gemcitabine. Therefore, it is hoped that more favorable results can be obtained by using guided immunotherapy against molecular targets. This review summarizes the new leading targeted therapies in pancreatic cancers, focusing on passive and specific immunotherapies. Passive immunotherapy may have a role for treatment in combination with radiochemotherapy, which otherwise destroys the immune system along with tumor cells. It includes mainly therapies targeting against kinases, including epidermal growth factor receptor, Ras/Raf/mitogenactivated protein kinase cascade, human epidermal growth factor receptor 2, insulin growth factor-1 receptor, phosphoinositide 3-kinase/Akt/m TOR and hepatocyte growth factor receptor. Therapies against DNA repair genes, histone deacetylases, micro RNA, and pancreatic tumor tissue stromal elements(stromal extracellular matric and stromal pathways) are also discussed. Specific immunotherapies, such as vaccines(whole cell recombinant, peptide, and dendritic cell vaccines), adoptive cell therapy and immunotherapy targeting tumor stem cells, have the role of activating antitumor immune responses. In the future, treatments will likely include personalized medicine, tailored for numerous molecular therapeutic targets of multiple pathogenetic pathways. | Andrada Seicean Livia Petrusel Radu Seicean | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 6 | A Comparative Analysis of Binary Logistic Regression and Analytical Hierarchy Process for Landslide Susceptibility Assessment in the Dobrovǎt River Basin,Romania显示文摘A correct assessment of the landslide susceptibility component is extremely useful for the diminution of associated potential risks to local economic development, particularly in regard to land use planning and soil conservation. The purpose of the present study was to compare the usefulness of two methods, i.e., binary logistic regression(BLR) and analytical hierarchy process(AHP), for the assessment of landslide susceptibility over a 130-km^2 area in the Moldavian Plateau(eastern Romania) region, where landslides affect large areas and render them unsuitable for agriculture. A large scale inventory mapping of all types of landslides(covering 13.7% of the total area) was performed using orthophoto images, topographical maps, and field surveys. A geographic information system database was created, comprising the nine potential factors considered as most relevant for the landsliding process. Five factors(altitude, slope angle, slope aspect, surface lithology, and land use) were further selected for analysis through the application of a tolerance test and the stepwise filtering procedure of BLR. For each predictor, a corresponding raster layer was built and a dense grid of equally spaced points was generated, with an approximately equal number of points inside and outside the landslide area, in order to extract the values of the predictors from raster layers. Approximately half of the total number of points was used for model computation, while the other half was used for validation. Analytical hierarchy process was employed to derive factor weights, with several pair-wise comparison matrices being tested for this purpose. The class weights, on a scale of 0 to 1, were taken as normalized landslide densities. A comparison of results achieved through these two approaches showed that BLR was better suited for mapping landslide susceptibility, with 82.8% of the landslide area falling into the high and very high susceptibility classes. The susceptibility class separation using standard deviation was superior to either the equal interval or the natural break method. Results from the study area suggest that the statistical model achieved by BLR could be successfully extrapolated to the entire area of the Moldavian Plateau. | Cristian V.PATRICHE Radu PIRNAU Adrian GROZAVU Bogdan ROSCA | 2016 | Pedosphere2016，26，3： | 11 |
| 7 | Is it better to use two elastographic methods for liver fibrosis assessment?显示文摘AIM:To find out if by combining 2 ultrasound based elastographic methods:acoustic radiation force impulse(ARFI)elastography and transient elastography(TE),we can improve the prediction of fibrosis in patients with chronic hepatitis C.METHODS:Our study included 197 patients with chronic hepatitis C.In each patient,we performed,in the same session,liver stiffness(LS)measurements by means of TE and ARFI,respectively,and liver biopsy(LB),assessed according to the Metavir score.10 LS measurements were performed both by TE and ARFI;median values were calculated and expressed in kilopascals(kPa)and meters/second(m/s),respectively.Only TE and ARFI measurements with IQR<30%andSR≥60%were considered reliable.RESULTS:On LB 13(6.6%)patients had F0,32(16.2%) had F1,52(26.4%)had F2,47(23.9%)had F3,and 53(26.9%)had F4.A direct,strong correlation was found between TE measurements and fibrosis(r=0.741),between ARFI and fibrosis(r=0.730)and also between TE and ARFI(r=0.675).For predicting significant fibrosis(F≥2),for a cutoff of 6.7 kPa,TE had 77.5% sensitivity(Se)and 86.5%specificity(Sp)[area under the receiver operating characteristic curve(AUROC)0.87] and for a cutoff of 1.2 m/s,ARFI had 76.9%Se and 86.7%Sp(AUROC 0.84).For predicting cirrhosis(F=4),for a cutoff of 12.2 kPa,TE had 96.2%Se and 89.6% Sp(AUROC 0.97)and for a cutoff of 1.8 m/s,ARFI had 90.4%Se and 85.6%Sp(AUROC 0.91).When both elastographic methods were taken into consideration,for predicting significant fibrosis(F≥2),(TE≥6.7 kPa and ARFI≥1.2 m/s)we obtained 60.5%Se,93.3% Sp,96.8%positive predictive value(PPV),41.4%negative predictive value(NPV)and 68%accuracy,while for predicting cirrhosis(TE≥12.2 kPa and ARFI≥1.8 m/s) we obtained 84.9%Se,94.4%Sp,84.9%PPV,94.4% NPV and 91.8%accuracy.CONCLUSION:TE used in combination with ARFI is highly specific for predicting significant fibrosis;therefore when the two methods are concordant,liver biopsy can be avoided. | Ioan Sporea Roxana Sirli Alina Popescu Simona Bota Radu Badea Monica Lupsor Mircea Focsa Mirela Danila | 2011 | World Journal of Gastroenterology2011，17，33： | 11 |
| 8 | Optical coherence tomography and Doppler optical coherence tomography in the gastrointestinal tract显示文摘Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical analyses.Lately,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more attractive.This paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract. | Eugen Osiac Adrian Sǎftoiu Dan Ionut Gheonea Ion Mandrila Radu Angelescu | 2011 | World Journal of Gastroenterology2011，17，1： | 8 |
| 9 | Learning tasks as a possible treatment for DNA lesions induced by oxidative stress in hippocampal neurons显示文摘Reactive oxygen species have been implicated in conditions ranging from cardiovascular dysfunction,arthritis,cancer,to aging and age-related disorders.The organism developed several pathways to counteract these effects,with base excision repair being responsible for repairing one of the major base lesions(8-oxoG) in all organisms.Epidemiological evidence suggests that cognitive stimulation makes the brain more resilient to damage or degeneration.Recent studies have linked enriched environment to reduction of oxidative stressin neurons of mice with Alzheimer's disease-like disease,but given its complexity it is not clear what specific aspect of enriched environment has therapeutic effects.Studies from molecular biology have shown that the protein p300,which is a transcription co-activator required for consolidation of memories during specific learning tasks,is at the same time involved in DNA replication and repair,playing a central role in the long-patch pathway of base excision repair.Based on the evidence,we propose that learning tasks such as novel object recognition could be tested as possible methods of base excision repair facilitation,hence inducing DNA repair in the hippocampal neurons.If this method proves to be effective,it could be the start for designing similar tasks for humans,as a behavioral therapeutic complement to the classical drug-based therapy in treating neurodegenerative disorders.This review presents the current status of therapeutic methods used in treating neurodegenerative diseases induced by reactive oxygen species and proposes a new approach based on existing data. | Dragos Cīrneci Radu Silaghi-Dumitrescu | 2013 | Neural Regeneration Research2013，8，32： | 7 |
| 10 | Maximizing the endosonography: The role of contrast harmonics, elastography and confocal endomicroscopy显示文摘New technologies in endoscopic ultrasound(EUS) evaluation have been developed because of the need to improve the EUS and EUS-fine needle aspiration(EUS- FNA) diagnostic rate. This paper reviews the principle, indications, main literature results, limitations and future expectations for each of the methods presented. Contrast-enhanced harmonic EUS uses a low mechanical index and highlights slowflow vascularization. This technique is useful for differentiating solid and cystic pancreatic lesions and assessing biliary neoplasms, submucosal neoplasms and lymph nodes. It is also useful for the discrimination of pancreatic masses based on their qualitative patterns; however, the quantitative assessment needs to be improved. The detection of small solid lesions is better, and the EUS-FNA guidance needs further research. The differentiation of cystic lesions of the pancreas and the identification of the associated malignancy features represent the main indications. Elastography is used to assess tissue hardness based on the measurement of elasticity. Despite its low negative predictive value, elastography might rule out the diagnosis of malignancy for pancreatic masses. Needle confocal laser endomicroscopy offers useful information about cystic lesions of the pancreas and is still under evaluation for use with solid pancreatic lesions of lymph nodes. | Andrada Seicean Ofelia Mosteanu Radu Seicean | 2017 | World Journal of Gastroenterology2017，23，1： | 6 |
| 11 | Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease显示文摘Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical outcome.Because of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis.The most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of diagnosis.Although they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising results.Another issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein thrombosis.In this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current guidelines.Moreover,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular circumstances.In this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients. | Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 12 | Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs. | Cristiana Pistol Tanase Ana Iulia Neagu Laura Georgiana Necula Cristina Mambet Ana-Maria Enciu Bogdan Calenic Maria Linda Cruceru Radu Albulescu | 2014 | World Journal of Gastroenterology2014，20，31： | 4 |
| 13 | Noninvasive assessment of alcoholic liver disease using unidimensional transient elastography(Fibroscan~)显示文摘Unidimensional transient elastography(TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the factors that may influence the result of fibrosis prediction, and last but not least, on its potential use in assessing the steatosis degree. Therefore, this field is far from being exhausted and deserves more attention. Further studies are required, on large groups of biopsied patients, in order to find answers to all the remaining questions in this field. | Monica Lupsor-Platon Radu Badea | 2015 | World Journal of Gastroenterology2015，21，42： | 4 |
| 14 | Genetic determination of irritable bowel syndrome显示文摘急躁的肠症候群(IBS ) 是普通功能的胃肠的混乱。根据罗马 III 标准, IBS 在下列症状的与二联系的以前的 3 瞬间或更多期间每月为至少 3 d 被定义为周期性的腹的疼痛或不快:有澄清,在凳子的频率与一个变化联系的发作或与一个变化联系处于良好的竟技状态的发作或凳子的外观的改进。在 IBS 关于基因贡献正在种证据,然而, IBS 的精确病原学仍然是未知的。基因影响的评估基于成双的研究,家庭聚集和基因流行病学调查。大多数研究比在 dizygotic 为在单合子显著地更大的 IBS 显示出一个词语索引。研究的多数证明了家庭聚集可以代表暴露到基因因素的类似的环境,以及影响。而没有特定的基因与 IBS 联合被识别了,最近的研究在血清素的倡导者区域注意了多型性的重要性再入伍拿 transporter 基因,G蛋白质贝它 3 子单元基因( C825T ),缩胆囊素受体( CCKAR 基因 779T >C ),并且高制片人的肿瘤坏死因素遗传型。进一步的研究是必要的决定基因因素怎么在 IBS 病人影响临床的表明和 therapeutical 反应。 | Cristina Hotoleanu Radu Popp Adrian Pavel Trifa Laurentiu Nedelcu Dan L Dumitrascu | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 15 | 多头带绦虫TPx基因片段的克隆及原核表达显示文摘从自然感染的病羊脑内采集多头蚴原头节,提取总RNA,采用RT-PCR技术扩增多头带绦虫硫氧还蛋白过氧化物酶(TmTPx)基因片段,PCR产物连接到pMD18-T载体,转化至大肠杆菌DH5α后测序,发现克隆到的TmTPx基因片段开放阅读框为453 bp,编码150个氨基酸。对TmTPx基因片段进行限制性酶切后连接到表达载体pGEX-4T-1,构建重组表达质粒pGEX-4T-TmTPx,转化大肠杆菌DH5α后筛选阳性克隆,经限制性酶切分析、PCR及测序鉴定后,转化大肠杆菌BL21,以IPTG进行诱导表达,用SDS-PAGE分析表达产物。结果显示,成功表达了大小约为43 ku的融合蛋白。对表达产物纯化后免疫家兔,采集血清用ELISA测定抗体效价,发现兔抗TmTPx重组蛋白的抗体能够与多头蚴原头节抗原发生特异性反应,说明该重组蛋白具有较好的免疫原性。 | 李永光 李文卉 李航 盖文燕 王鸿盛 姚菊霞 王艳华 张德林 贾万忠 Radu Blaga 付宝权 | 2009 | 中国兽医科学2009，39，3： | 4 |
| 16 | Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study显示文摘 | Ioan Sporea Simona Bota Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Radu Badea Monica Lupsor Carmen Fierbinteanu-Braticevici Ana Petrisor Hidetsugu Saito Hirotoshi Ebinuma Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2012 | European Journal of Radiology2012，，12： | 3 |
| 17 | Inflammatory bowel disease: role of diet, microbiota, life style显示文摘 | Manuela G. Neuman Radu M. Nanau | 2012 | Translational Research2012，，1： | 2 |
| 18 | Towards 3D Point cloud based object maps for household environments显示文摘 | Radu Bogdan Rusu Zoltan Csaba Marton Nico Blodow Mihai Dolha Michael Beetz | 2008 | Robotics and Autonomous Systems2008，，11： | 2 |
| 19 | Optimum Design of Outrigger and Belt Truss Systems Using Genetic Algorithm显示文摘 | Radu Hulea Bianca Parv Monica Nicoreac Bogdan Petrina | 2014 | Journal of Civil Engineering and Architecture2014，8，6： | 2 |
| 20 | Evaluation of the seismic hazard for 20 cities in Romania using Monte Carlo based simulations显示文摘This work focuses on the evaluation of the seismic hazard for Romania using earthquake catalogues generated by a Monte Carlo approach. The seismicity of Romania can be attributed to the Vrancea intermediate-depth seismic source and to 13 other crustal seismic sources. The recurrence times of large magnitude seismic events(both crustal and subcrustal), as well as the moment release rates are computed using simulated earthquake catalogues. The results show that the largest contribution to the overall moment release for the crustal seismic sources is from the seismic regions in Bulgaria, while the seismic regions in Romania contribute less than 5% of the overall moment release. In addition, the computations show that the moment release rate for the Vrancea subcrustal seismic source is about ten times larger than that of all the crustal seismic sources. Finally, the Monte Carlo approach is used to evaluate the seismic hazard for 20 cities in Romania with populations larger than 100,000 inhabitants. The results show some differences between the seismic hazard values obtained through Monte-Carlo simulation and those in the Romanian seismic design code P100-1/2013, notably for cities situated in the western part of Romania that are influenced by local crustal seismic sources. | Florin Pavel Radu Vacareanu | 2017 | Earthquake Engineering and Engineering Vibration2017，16，3： | 2 |
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