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| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Is it better to use two elastographic methods for liver fibrosis assessment?显示文摘AIM:To find out if by combining 2 ultrasound based elastographic methods:acoustic radiation force impulse(ARFI)elastography and transient elastography(TE),we can improve the prediction of fibrosis in patients with chronic hepatitis C.METHODS:Our study included 197 patients with chronic hepatitis C.In each patient,we performed,in the same session,liver stiffness(LS)measurements by means of TE and ARFI,respectively,and liver biopsy(LB),assessed according to the Metavir score.10 LS measurements were performed both by TE and ARFI;median values were calculated and expressed in kilopascals(kPa)and meters/second(m/s),respectively.Only TE and ARFI measurements with IQR<30%andSR≥60%were considered reliable.RESULTS:On LB 13(6.6%)patients had F0,32(16.2%) had F1,52(26.4%)had F2,47(23.9%)had F3,and 53(26.9%)had F4.A direct,strong correlation was found between TE measurements and fibrosis(r=0.741),between ARFI and fibrosis(r=0.730)and also between TE and ARFI(r=0.675).For predicting significant fibrosis(F≥2),for a cutoff of 6.7 kPa,TE had 77.5% sensitivity(Se)and 86.5%specificity(Sp)[area under the receiver operating characteristic curve(AUROC)0.87] and for a cutoff of 1.2 m/s,ARFI had 76.9%Se and 86.7%Sp(AUROC 0.84).For predicting cirrhosis(F=4),for a cutoff of 12.2 kPa,TE had 96.2%Se and 89.6% Sp(AUROC 0.97)and for a cutoff of 1.8 m/s,ARFI had 90.4%Se and 85.6%Sp(AUROC 0.91).When both elastographic methods were taken into consideration,for predicting significant fibrosis(F≥2),(TE≥6.7 kPa and ARFI≥1.2 m/s)we obtained 60.5%Se,93.3% Sp,96.8%positive predictive value(PPV),41.4%negative predictive value(NPV)and 68%accuracy,while for predicting cirrhosis(TE≥12.2 kPa and ARFI≥1.8 m/s) we obtained 84.9%Se,94.4%Sp,84.9%PPV,94.4% NPV and 91.8%accuracy.CONCLUSION:TE used in combination with ARFI is highly specific for predicting significant fibrosis;therefore when the two methods are concordant,liver biopsy can be avoided. | Ioan Sporea Roxana Sirli Alina Popescu Simona Bota Radu Badea Monica Lupsor Mircea Focsa Mirela Danila | 2011 | World Journal of Gastroenterology2011，17，33： | 11 |
| 3 | Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study显示文摘 | Ioan Sporea Simona Bota Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Radu Badea Monica Lupsor Carmen Fierbinteanu-Braticevici Ana Petrisor Hidetsugu Saito Hirotoshi Ebinuma Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2012 | European Journal of Radiology2012，，12： | 3 |
| 4 | Performance of a new elastographie method (ARFI technology) compared to unidimensioual transient elastography in the noninvasive assessment of chronic hepatitis C: preliminary results 显示文摘 | Lupsor M Badea R Stefanescu H | 2009 | J Gastrointest Liver Dis2009，18，3： | 1 |
| 5 | Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C ; results from a cohort of 446 patients 显示文摘 | Crisan D Radu C Lupsor M | 2012 | Hepat Mon2012，12，3： | 1 |
| 6 | Performance ofAcoustic Radiation Force Impulse imaging for the staging of liverfibrosis:a pooled meta-analysis显示文摘 | Friedrich-Rust M Nierhoff J Lupsor M | 2012 | Viral Hepat2012，19，： | 1 |
| 7 | 1375 SPLEEN STIFFNESS MEASUREMENT USING FIBROSCAN AND A MODIFIED CALCULATION ALGORITHM INCREASES THE DIAGNOSIS PERFORMANCE OF LARGE ESOPHAGEAL VARICES IN CIRRHOTIC PATIENTS显示文摘 | H. Stefanescu C. Bastard M. Lupsor D. Feier V. Miette L. Sandrin R. Badea | 2011 | Journal of Hepatology2011，，： | 1 |
| 8 | Performance of acoustic radiation force impulse imaging for the staging of liver fibrosis: a pooled meta-analysis 显示文摘 | Friedrich-Rust M Nierhoff J Lupsor M | 2012 | J Viral Hepat2012，19，2： | 1 |
| 9 | Is there any place for spleen stiffness measurement in portal hypertension?显示文摘 | Stefanescu H Procopet B Platon- Lupsor M | 2013 | Am J Gastroenterol2013，108，10： | 1 |
| 10 | Spleen stiffness measurement using Fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients显示文摘 | Stefanescu H Grigorescu M Lupsor M | 2011 | J Gastroenterol Hepatol2011，26，1： | 1 |
| 11 | Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients显示文摘 | Crisan D Radn C Lupsor M | 2012 | Hepat Mon2012，12，3： | 1 |
| 12 | Liver stiffness is influ- enced by a standardized meal in patients with chronic hepatitis c virus at different stages of fibrotic evolution 显示文摘 | Arena U Lupsor Platon M Stasi C | 2013 | Hepatology2013，58，1： | 1 |
| 13 | Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C;Results from a cohort of 446 patients显示文摘 | Crisan D Radu C Lupsor M | | 0，，： | 1 |
| 14 | Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution显示文摘 | Arena U Lupsor Platon M Stasi C | 2013 | Hepatology2013，58，1： | 1 |
| 15 | The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: a retrospective multicentre study显示文摘 | Simona Bota Ioan Sporea Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Hidetsugu Saito Hirotoshi Ebinuma Monica Lupsor Radu Badea Carmen Fierbinteanu-Braticevici Ana Petrisor Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 16 | Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis显示文摘 | Fricdrich-Rust M Nierhoff J Lupsor M | 2012 | J V~al Hepatitis2012，19，2： | 1 |
| 17 | Two or more syn- chronous combination of noninvasive tests to increase accu- racy of liver fibrosis assessement in chronic hepatitis C re- sults from a cohort of 446 patients显示文摘 | CRISAN D RADU C LUPSOR M | 2012 | Hepat Mort2012，12，3： | 1 |
| 18 | Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study显示文摘 | Ioan Sporea Simona Bota Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Radu Badea Monica Lupsor Carmen Fierbinteanu-Braticevici Ana Petrisor Hidetsugu Saito Hirotoshi Ebinuma Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2012 | European Journal of Radiology2012，，12： | 1 |
| 19 | Spleen stiffness measurement using Fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients 显示文摘 | Stefanescu H Grigorescu M Lupsor M | 2011 | J Gastroenterol Hepatol2011，26，1： | 1 |
| 20 | Diagnosis and characteri- zation of cutaneous tumors using combined ultrasonography pro- cedures (conventional and high resolution ultrasonography)显示文摘 | Badea R Crisan M Lupsor M | 2010 | Med Ultrason2010，12，： | 1 |
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