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| 1 | 卒中或短暂性脑缺血发作患者的卒中预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南显示文摘本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐,包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外,还对其他许多特殊情况下的复发性卒中预防提供了推荐意见,包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中(尤其是与妊娠和绝经后雌激素替代治疗相关性卒中)、脑出血后抗凝药的使用等,以及实施本指南及其在高危人群中应用的特定方法。 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia Wassertheil-Smoller Tanya N. Turan Deidre Wentworth 李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) | 2011 | 国际脑血管病杂志2011，19，1： | 391 |
| 2 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 3 | 单味中药提取物对体外培养的黑素细胞酪氨酸酶基因和c-kit基因表达的激活作用显示文摘目的研究补骨脂、白芷、夏枯草、川芎和墨旱莲单味中药提取物对黑素细胞的酪氨酸酶基因和原癌基因c-kit蛋白表达的影响,以及对总蛋白合成的影响。方法采用蛋白印迹法检测了酪氨酸酶蛋白和干细胞因子受体kit蛋白含量的变化;595nm比色标准曲线测定黑素细胞可溶性总蛋白含量。结果白芷、补骨脂、夏枯草、川芎和墨旱莲对黑素细胞可溶性总蛋白合成和c-kit基因蛋白表达有促进作用,其中白芷和补骨脂对c-kit基因蛋白表达的促进作用为69.44%和58.43%;夏枯草、墨旱莲和川芎对酪氨酸酶基因的蛋白表达有一定的促进作用。结论在白癜风治疗中传统中药具有较好的疗效,可能与酪氨酸激酶受体蛋白含量的提高相关,即通过SCF/kit蛋白途径起作用,因此可以通过该途径进一步筛选更多治疗白癜风的单味中药。 | 李永伟 许爱娥 Ruth Halaban | 2004 | 中华皮肤科杂志2004，37，10： | 46 |
| 4 | 中国中部用水者协会对农户生产的影响显示文摘本文的研究旨在检验政府采取参与式灌溉管理(PIM)和用水者协会改革政策的效果。对湖北漳河灌区和东风灌区208户农户的问卷调查资料进行了统计分析和计量经济模型分析,研究结果表明用水者协会的成立对农户灌溉水资源供应和农业生产产生了积极影响。调查中有80%的农户肯定了用水者协会的作用,用水者协会调动了农户进行渠道维护和管理的积极性。用水者协会可以继续作为我国灌溉管理改革的一个方向和选择。 | 刘静 Ruth Meinzen-Dick 钱克明 张陆彪 蒋藜 | 2008 | 经济学(季刊)2008，7，1： | 42 |
| 5 | 颈动脉粥样硬化疾病的处理美国血管外科学会临床实践指南显示文摘美国血管外科学会(SVS)任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中,该委员会使用系统评价对当前最件的证据进行了总结,采用GRADE标准对推荐意见的强度(强烈推荐为GRADEI级,一般推荐为GRADEⅡ级)和证据的质量(高、中、低和极低)进行了分级。对于轻度颈动脉狭窄患者(有症状患者狭窄程度〈50%和无症状患者狭窄程度〈60%),推荐进行最佳的内科治疗而非血管重建术(I级推荐,高质量证据)。对于有症状中到重度狭窄患者(狭窄程度≥50%),推荐行颈动脉内膜切除术(CEA)+最佳的内科治疗(I级推荐,高质量证据)。对于围手术期风险高的有症状巾到重度狭窄患者(狭窄程度≥50%),建议采用颈动脉支架置入术作为其替代治疗手段(Ⅱ级推荐,低质量证据)。对于中到重度狭窄的无症状患者(狭窄程度≥60%),只要围手术期风险较低,就推荐行CEA+内科治疗(I级推荐,高质量证据)。对于中到重度狭窄的尢症状患者(狭窄稗度≥60%),不推荐行颈动脉支架置入术(I级推荐,低质量证据)。颈动脉狭窄≥80%但存在CEA高危解剖学风险的患者可能是一个例外。 | Robert W. Hobson, Ⅱ William C. Mackey Enrico Ascher M. Hassan Murad Keith D. Calligaro Anthony J. Comerota Victor M. Montori Mark K. Eskandari Douglas W. Massop Ruth L. Bush Brajesh K. Lal Bruce A. Perler 刘德志(译) 徐格林(译) 刘新峰(译) | 2008 | 国际脑血管病杂志2008，16，12： | 35 |
| 6 | Non-invasive diagnosis of liver fibrosis and cirrhosis显示文摘The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this 'gold-standard' is imperfect; even according to its proponents, it is only 'the best' among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. | Yoav Lurie Muriel Webb Ruth Cytter-Kuint Shimon Shteingart Gerardo Z Lederkremer | 2015 | World Journal of Gastroenterology2015，21，41： | 36 |
| 7 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 8 | 菌株Arthrobacter sp.CN2降解对硝基苯酚的特性与动力学显示文摘为研究对硝基苯酚降解菌Arthrobacter sp.CN2在实际生产中的应用潜力,本文分别分析了p H、盐浓度和额外添加碳源对降解效率的影响,同时对降解的动力学方程进行拟合分析.菌株CN2在p H 7.0~8.0,Na Cl浓度60 g·L-1之间能够高效降解对硝基苯酚,72 h内对50 mg·L-1对硝基苯酚的降解率均大于90%.同时发现适量添加葡萄糖(0.5%)可显著促进CN2降解对硝基苯酚,与不添加葡萄糖条件下相比,达到90%降解率所需时间缩短了16 h.当对硝基苯酚浓度低于300 mg·L-1时,菌株CN2对对硝基苯酚的降解符合一级动力学方程,降解速率常数在0.021 7~0.025 0之间.在生物反应器中应用菌株CN2模拟处理工业废水,3 L含对硝基苯酚废水(100 mg·L-1)在72h的降解率大于90%.研究表明,菌株Arthrobacter sp.CN2能够高效地降解对硝基苯酚,对于环境有良好适应能力,具有良好的应用前景. | 任磊 史延华 贾阳 姚雪松 Ruth Nahurira 弥春霞 闫艳春 | 2015 | 环境科学2015，36，5： | 24 |
| 9 | Spatial patterns of plant diversity and communities in Alpine ecosystems of the Hengduan Mountains, northwest Yunnan, China显示文摘Aims Conduct a quantitative,but rapid,regional-level assessment of the alpine flora across northwest Yunnan(NWY)to provide a broadbased understanding of local and regional patterns of the composition,diversity and health of alpine ecosystems across NWY.Methods A stratified random sampling design was employed to select sites across the different mountain ranges of NWY.Vegetation was sampled by stratifying each site by the three major alpine vegetation community types:meadow,dwarf shrub and scree.Two 50-m transects were randomly located within each community type at each sampling site with 101-m^(2) subplots systematically placed along each transect.Environmental variables were recorded at each transect.Multivariate analyses were used to classify the major plant community assemblages and link community patterns to environmental and habitat variables.Important Findings Forb species richness varied from 19 to 105 species per site(21 sites total)with an average of 59 species per site(60 m^(2) sampled per site).Most species were patchily distributed with narrow distributions and/or small population sizes;over half the species occurred at only one or two sites.Distinct species assemblages were identified in the meadow vegetation that was strongly aggregated by geographic location suggesting the presence of distinct phytogeographic zones of the meadow alpine flora.Elevation and geographic location were the dominant environmental gradients underlying the variations in species composition.Jaccard’s coefficient of similarity averaged only 10%among sites indicating there was little similarity in the alpine flora across the region.The alpine vegetation is highly heterogeneous across the complex landscape of the Hengduan Mountains of NWY.Conservation strategies need to take into account the large geographic differences in the flora to maximize protection of biodiversity. | Ruth Sherman Renee Mullen Li Haomin Fang Zhendong Wang Yi | 2008 | Journal of Plant Ecology2008，1，2： | 20 |
| 10 | 远程耦合世界的可持续性框架显示文摘远距离之间的相互作用及其影响日益广泛。这种远程相互作用往往会对可持续发展产生深远的影响并会造成意想不到的结果。很多可持续性研究都是针对某个特定地点进行的,很少注重多个地点之间远程相互作用对可持续性所产生的影响。虽然有些研究涉及到远程因素,但通常都把它们看作外在变量,而未把它们看作反馈。为了更好地理解和综合各种远程相互作用,本文提出了一种基于远程耦合的综合框架,它是一个远距离社会经济和环境相互作用的总体概念。人类与自然耦合系统是研究在特定地点发生的相互作用,远程耦合概念是对人类与自然耦合系统研究的自然延伸。远程耦合框架包括五个相关的组成部分,即:人类与自然耦合系统、流、代理、原因、和影响。本文通过农产品贸易和物种入侵两个远程相互作用的例子来解释远程耦合框架,重点阐述远程耦合框架的影响,并讨论促进远程耦合研究发展的研究条件和方法。这个框架有助于分析系统内各组成部分以及它们之间的相互关系,找出研究差距,探索其中的隐含成本以及尚未开发的优势,提供引入反馈及多系统(发送、接收和外溢系统)之间权衡和协同的有效手段,从本地到全球各个层面加深对远程相互作用的认识,并提高社会经济和环境可http://gffzz31576c8fc0de4618h6nn5wk0vk6vn6ff9.ffgz.tsg.suse.edu.cn续发展政策的有效性。 | 刘建国 Vanessa Hull Mateus Batistella Ruth DeFries Thomas Dietz 付峰 Thomas W.Hertel R.Cesar Izaurralde Eric F.Lambin 李舒心 Luiz A.Martinelli William J.McConnell Emilio F.Moran Rosamond Naylor 欧阳志云 KarenR.Polenske Anette Reenberg Gilberto de Miranda Rocha Cynthia S.Simmons Peter H.Verburg Peter M.Vitousek 张福锁 朱春全 | 2016 | 生态学报2016，36，23： | 19 |
| 11 | Volar locking distal radius plates show better short-term results than other treatment options: A prospective randomised controlled trial显示文摘AIM To compare the outcomes of displaced distal radius fractures treated with volar locking plates and with immediate postoperative mobilisation with the outcomes of these fractures treated with modalities that necessitate 6 wk wrist immobilisation.METHODS A prospective, randomised controlled single-centre trial was conducted with 56 patients who had a displaced radius fracture were randomised to treatment either with a volar locking plate(n = 29), or another treatment modality(n = 27; cast immobilisation with or without wires or external fixator). Outcomes were measured at 12 wk. Functional outcome scores measured were the Patient-Rated Wrist Evaluation(PRWE) Score; Disabilities of the Arm, Shoulder and Hand and activities of daily living(ADLs). Clinical outcomes were wrist range of motion and grip strength. Radiographic parameters were volar inclination and ulnar variance.RESULTS Patients in the volar locking plate group had significantly better PRWE scores, ADL scores, grip strength and range of extension at three months compared with the control group. All radiological parameters were significantly better in the volar locking plate group at 3 mo. CONCLUSION The present study suggests that volar locking plates produced significantly better functional and clinical outcomes at 3 mo compared with other treatment modalities. Anatomical reduction was significantly more likely to be preserved in the plating group. Level of evidence: Ⅱ. | Herwig Drobetz Lidia Koval Patrick Weninger Ruth Luscombe Paula Jeffries Stefan Ehrendorfer Clare Heal | 2016 | World Journal of Orthopedics2016，7，10： | 18 |
| 12 | 干辣椒风味物质气相色谱及质谱方法的研究显示文摘用嗅觉测量法-气相色谱联用(GC-O),火焰离子检测器-气相色谱联用(GC-FID),质谱-气相色谱联用(GC-MS)三种气相色谱检测方法和常压化学离子化飞行时间质谱(APCI-TOFMS),质子传递反应质谱(PTR-MS)两种直接质谱检测方法来比较测定干辣椒中的挥发性香味成分。干辣椒的挥发性香味成分的大体描述最后由感官评定来确定。三种较显著的风味分别是:辣椒味、煮熟蔬菜味和青草味。用气质联用顶空分析法共有63种挥发性香味成分被分离出来。而嗅觉测量法-气相色谱联用(GC-O)认为其中的11种成分决定了辣椒的香味活跃程度。在所有的方法中普遍认为:3-甲基正丁醛是最活跃的香味成份,其次是2-甲基正丁醛。确定挥发性香味成分的多少主要是受测定方法的影响。色谱方法之间有很强的相关性(ρ=0.946)。直接质谱法相关性不显著(ρ=0.613)。经过不同方法的分析,我们发现,用GC-MS,GC-FID和PTR-MS三种方法检测出的挥发性香味成分并没有显著的不同,显著性的差异主要存在于PCI-TOFMS法和其工艺的不同(P<0.01).(Int J Mass Spectrom223-224(2003)55-65) | Saskia van Ruth Elena Boscaini Dagmar Mayr Jonathan Pugh Maarten Posthumus 刘蓉 刘志敏 | 2007 | 辣椒杂志2007，，1： | 15 |
| 13 | Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis显示文摘 | Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge | 2017 | Molecular Plant2017，10，10： | 15 |
| 14 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 15 | 肺癌危险度与室内氡关系研究:中国两项研究的汇总分析结果显示文摘目的 居室氡暴露是导致肺癌死亡的第二位重要原因,这是地下矿工氧暴露研究的外推结果。本分析就是为了验证此预测的正确性。方法 中国进行的两项居室氡暴露肺癌病例-对照研究共包括1050肺癌病例和1996名对照,把这些数据汇总在一起进行分析。结果 根据线性模型,在95%置信区间情况下,每100Bq/m^3的附加比值比(EOR)为0.133(0.01,0.036)。对在现住所居住30a以上的调查对象进行分析,EOR值为0.315(0.07,0.91)。此估算值与矿工数据外推值及北美和欧洲室内氡研究结果类似。结论 在众多居室中普遍存在的氡浓度长期暴露,会使肺癌危险度增加。 | Jay H.Lubin 王作元 John D.Boice Jr 徐肇翊 William J.Blot 王陇德 Ruth A.Kleinerman | 2003 | 中国辐射卫生2003，12，4： | 13 |
| 16 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 12 |
| 17 | The immune modifying effects of amino acids on gut-associated lymphoid tissue显示文摘The intestine and the gut-associated lymphoid tissue(GALT) are essential components of whole body immune defense,protecting the body from foreign antigens and pathogens,while allowing tolerance to commensal bacteria and dietary antigens.The requirement for protein to support the immune system is well established.Less is known regarding the immune modifying properties of individual amino acids,particularly on the GALT.Both oral and parenteral feeding studies have established convincing evidence that not only the total protein intake,but the availability of specific dietary amino acids(in particular glutamine,glutamate,and arginine,and perhaps methionine,cysteine and threonine) are essential to optimizing the immune functions of the intestine and the proximal resident immune cells.These amino acids each have unique properties that include,maintaining the integrity,growth and function of the intestine,as well as normalizing inflammatory cytokine secretion and improving T-lymphocyte numbers,specific T cell functions,and the secretion of IgA by lamina propria cells.Our understanding of this area has come from studies that have supplemented single amino acids to a mixed protein diet and measuring the effect on specific immune parameters.Future studies should be designed using amino acid mixtures that target a number of specific functions of GALT in order to optimize immune function in domestic animals and humans during critical periods of development and various disease states. | Megan R Ruth Catherine J Field | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 11 |
| 18 | Diagnosis of clinical and subclinical varicocele: how has it evolved?显示文摘在这评论,我们为在一个精索静脉曲张病人的评估以 venography, scintigraphy,和 thermography 和他们的角色开始的精索静脉曲张检验各种各样的诊断形式的进化和申请。一些这些方法被不太侵略、更容易执行的诊断形式,特别超声和阴囊的 Doppler 检查取代了。在超声和磁性的回声成像的进展保持潜力在精索静脉曲张的视觉证实和描述的以外扩展成像的角色。基于成像调查结果识别阴囊的机能障碍的早指示物的能力以后可以为精索静脉曲张的管理有含意。 | Ruth E Belay Gene Omar Huang Jim Ken-Chie Shen Edmund Yuey Kun Ko | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 19 | 心脏再同步治疗对心肌复极的影响及其潜在致心律失常作用显示文摘目的以双心室起搏为核心技术的心脏再同步治疗技术(CRT)用于治疗慢性心力衰竭(CHF)时可能引起心肌复极异常而具有潜在的致心律失常危险性。本研究以接受CRT的CHF患者为对象,观察反映心肌复极特性的心电图指标在不同部位起搏时的变化及差异,并结合患者转归探讨其意义。方法21例接受CRT和/或CRT-D治疗的CHF患者入选。在植入术过程中或者复查时,将CRT装置分别程控为右心室心内膜起搏(RV-Endo)、左心室心外膜起搏(LV-Epi)和双心室起搏(Biv),同步记录12导联心电图,测量心电图上反映复极时间和复极差异的指标QT间期、JT间期和Tp-e间期,并在不同起搏部位间比较这些参数的差异。结果准确反映心肌复极时间的JT间期和公认代表心肌跨室壁复极离散的Tp-e间期均在LV-Epi起搏时最长[(341.78±61.69)ms,(199.70±62.44)ms],Biv起搏时次之[(325.86±59.19)ms,(184.89±74.08)ms],RV-Endo起搏时最短[(286.14±38.68)ms,(146.41±31.16)ms],三者比较差异有统计学意义(P<0.0001)。QT间期的变化有类似趋势但差异无统计学意义。在(29.18±18.38)个月的随访期中,共发生4例死亡,其中1例猝死,1例发生“心律失常风暴”并最终死于无休止性室性心动过速。结论在CHF患者已有器质性心肌病变的基础上,左心室心外膜起搏和目前CRT采用的双心室起搏延长心肌复极时间并增大跨室壁心肌复极离散,从而为促进恶性心律失常的发生提供了“基质”。 | 吕家高 林立 白融 Wee Siong Teo Ruth Kam 王琳 | 2006 | 中华心律失常学杂志2006，10，2： | 10 |
| 20 | Systematic review:Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors显示文摘AIM:To assess laparoscopic fundoplication(LF)in partial responders to proton pump inhibitors(PPIs)for gastroesophageal reflux disease(GERD).METHODS:We systematically searched PubMed and Embase(1966-Dec 2011)for articles reporting data on LF efficacy in partial responders.Due to a lack of randomized controlled trials,observational studies were included.Of 558 articles screened,17 were eligible for inclusion.Prevalence data for individual symptoms were collated across studies according to mutually compatible time points(before and/or after LF).Where suitable,prevalence data were presented as percentage of patients reporting symptoms of any frequency or severity.RESULTS:Due to a lack of standardized reporting of symptoms,the proportion of patients experiencing symptoms was recorded across studies where possible.After LF,the proportion of partial responders with heartburn was reduced from 93.1%(5 studies)to 3.8%(5 studies),with similar results observed for regurgitation[from 78.4%(4 studies)to 1.9%(4 studies)].However,10 years after LF,35.8%(2 studies)of partial responders reported heartburn and 29.1%(1 study)reported regurgitation.The proportion using acidsuppressive medication also increased,from 8.8%(4studies)in the year after LF to 18.2%(2 studies)at 10years.In the only study comparing partial responders to PPI therapy with complete responders,higher symptom scores and more frequent acid-suppressive medication use were seen in partial responders after LF.CONCLUSION:GERD symptoms improve after LF,but subsequently recur,and acid-suppressive medication use increases.LF may be less effective in partial responders than in complete responders. | Lars Lundell Martin Bell Magnus Ruth | 2014 | World Journal of Gastroenterology2014，20，3： | 10 |
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