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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Usefulness of biodegradable polydioxanone stents in the treatment of postsurgical colorectal strictures and fistulas显示文摘 | F. Pérez Roldán P. González Carro M. Villafá?ez García S. Aoufi Rabih M. Legaz Huidobro N. Sánchez-Manjavacas Mú?oz O. Roncero García-Escribano M. Ynfante Ferrús E. Bernardos Martín F. Ruiz Carrillo | 2012 | Endoscopy2012，，03： | 2 |
| 3 | Acute respiratory distress syndrome in trauma patients : ICU mortality and prediction factors 显示文摘 | Navarrete - Navarro P Ruiz -Bailen M Rinera Fernandez R | 2000 | Intensive Care Med2000，26，： | 1 |
| 4 | A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst显示文摘 | Romanelli G P Bennardi D Ruiz D M | 2004 | Tetrahedron Letters2004，45，48： | 1 |
| 5 | Biogenic amine production by Oenococcus oeni isolates from malolactic fermentation of Tempranillo wine显示文摘 | IZQUIERDO-CANAS P M GOMEZ ALONSO S RUIZ PEREZ P | 2009 | Journal of Food Protection2009，72，4： | 1 |
| 6 | Bile salts hydrolase plays a key role on cho- lesterol removal by Lactobacillus reuteri显示文摘 | TARANTO M P SESMA F DE RUIZ HOLGADO A P | 1997 | Biotech- nology Letters1997，19，9： | 1 |
| 7 | Modulation of renal disease in MRL/Ipr mice by suberoylanilide hydroxamic acid 显示文摘 | Reilly C M Mishra N Miller J M Joshi D Ruiz P Riehon V M | 2004 | J ImmunoI2004，173，： | 1 |
| 8 | Performance evaluation of existing approaches for hybrid ad hoc networks across mobility models显示文摘 | FRANCISCO R J RUIZ P M GOMEZ S A | 2006 | Journal of Net Works2006，1，2： | 1 |
| 9 | Selection of autochthonous Oenococcus oeni strains according to their oenological properties and vinification results显示文摘 | RUIZ P IZQUIERDO M P SESEIqA S | 2010 | International Journal of Food Microbiology2010，137，23： | 1 |
| 10 | Catalytic performances and stability of three Sb-Mo-O phases in the selective oxidation of isobutene to methacrolein显示文摘 | GAIGNEAUX E M DIETERIE M RUIZ P | 1998 | J Phys Chem B1998，102，10： | 1 |
| 11 | Resistance to cold and heat stress: accumulation of phenolic compounds in tomato and watermel- on plants显示文摘 | Rivem R M Ruiz J M Garcia P C | 2001 | Plant Science2001，160，： | 1 |
| 12 | The role of bismuth as promoter in Pd-Bi catalysts for the selective oxidation of glucose to gluconate 显示文摘 | Wenkin M Ruiz P Delmon B | 2002 | Journal of molecular catalysis A: chemical2002，180，： | 1 |
| 13 | Be- yond Wnt inhibition: new functions of secreted Friz- zled-related proteins in development and disease显示文摘 | BOVOLENTA P ESTEVE P RUIZ J M | 2008 | J Cell Sci2008，121，： | 1 |
| 14 | Microcellular Foaming of Polymethylmethacrylate in a Bath Supercritical CO2 Process: Effect of Microstructure on Compression Behavior显示文摘 | RUIZ J A R VIOT P DUMON M | 2010 | Journal of Applied Polymer Science2010，118，1： | 1 |
| 15 | Uteroplacental circulation in patients with fast-trimester threatened abortion 显示文摘 | Alcazar J L Ruiz P M L | 2000 | Fertil Steril2000，73，3： | 1 |
| 16 | Identification of sulfur volatiles in canned orange juices lacking orange flavor显示文摘 | RUIZ PEREZ-CACHO P MAHATTANATAWEE K SMOOT J M | 2007 | Journal of Agricultural and Food Chemistry2007，55，14： | 1 |
| 17 | Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription(STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer显示文摘 | VAN C H RUIZ M G VAN D V P | 2009 | BMC Cancer2009，9，： | 1 |
| 18 | Isotopic tracing experiments in syngas pro- duction from methane on Ru/A12 03 and Ru/SiO2 显示文摘 | Guerrero Ruiz A Ferreira Aparicio P Bachiller Baeza M B | 1998 | Catalysis Today1998，46，23： | 1 |
| 19 | Optimization of biomass fuelled systems for distributed power generation using particle swarm optimization 显示文摘 | Reche Lopez P Comes G M Ruiz R N | 2008 | Electric Power Systems Research2008，78，8： | 1 |
| 20 | Comparison of two molecular methods for rapid diagnosis of extrapulmonary tubercu- losis显示文摘 | Causse M Ruiz P Guti6rrez-Aroca JB | 2011 | J Clin Microbiol2011，49，8： | 1 |
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