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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 3 | Quantization and distribu-tion of altered fatty acids in frying fats显示文摘 | Ruiz G M Margari M Dobarganes | 1995 | Journal of the A-merican Oil Chemists''Society1995，72，10： | 1 |
| 4 | Effects of centrifugation before freezing on boar sperm cryosurvival显示文摘 | Carvajal G Cuello C Ruiz M | 2004 | J Androl2004，25，3： | 1 |
| 5 | Insights into the structural and chemical modifications of Nb additive on TiO2 nanopar- titles 显示文摘 | ANA M RUIZ DEZANNEAU G ARBIOL J | 2004 | Chem Mater2004，16，5： | 1 |
| 6 | Perform ance of a LiBr-water absorption chiller operating with plate heat exchangers 显示文摘 | M de Vega J A Almendros-Iba flez G Ruiz | 2006 | Energy Conversion and Management2006，47，： | 1 |
| 7 | Genetic algorithms and particle swarm optimization for exploratory projection Applying PPE model based on RAGA to classify and evaluate soil grade pursuit显示文摘 | Berro A Larabi M S Ruiz A G | | 0，，60： | 1 |
| 8 | Synergistic interaction between ciaplatin and gemcitabine in vitro 显示文摘 | Bergman A M Ruiz van Haperen V W Veerman G | 1996 | Clin Cancer Res1996，2，3： | 1 |
| 9 | Deploying a wireless sensor network on an active volcano显示文摘 | WERNER-ALLEN G LORINCZ K RUIZ M | 2006 | IEEE Internet Computing2006，10，2： | 1 |
| 10 | ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells显示文摘 | Wang E C Lee J M Ruiz W G | 2005 | J Clin Invest2005，115，9： | 1 |
| 11 | A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst显示文摘 | Romanelli G P Bennardi D Ruiz D M | 2004 | Tetrahedron Letters2004，45，48： | 1 |
| 12 | Microstructure control of thermally stable TiO2 obtained by hydrothermal process for gas sensors显示文摘 | Ruiz A M Sakai G Comet A | 2004 | Sensors and Actuators B: Chemical2004，103，12： | 1 |
| 13 | BTA copper complexes显示文摘 | FRIEDRICH M RUIZ J C G KLAPOLTKE T M | 2005 | Inorg Chem2005，44，22： | 1 |
| 14 | Experimental Study of Fracture of Lightly Reinforced Concrete Beams显示文摘 | Ruiz G Elices M Planas J | | 0，，214： | 1 |
| 15 | Psoriatic arthritis: a clinical entity distinct from psoriasis? 显示文摘 | Ruiz D G Azevedo M N Santos O L | 2012 | Rev Bras Reumatol2012，52，4： | 1 |
| 16 | Global spread of microorganisms by ships显示文摘 | Ruiz G M Rawlings T K Dobbs F C | 2000 | Nature2000，408，6808： | 1 |
| 17 | Clinical manifestations and survival trends during the first 12 years of the AIDS epidemic in Mexico显示文摘 | VILLASIS - KWWCWE A RANGEL - FRAUSTO M S RUIZ - PALACIOS G | 2001 | Arch Med Res2001，，32： | 1 |
| 18 | In vitro activity of new fluoroquinolones and linezolid against non-tuberculous mycobacteria显示文摘 | Rodriguez Diaz JC Lopez M Ruiz M Royo G | 2003 | Int J Antimicrobial Agents2003，21，： | 1 |
| 19 | Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaueoma显示文摘 | Schori H Kipnis J Yoles E WoldeMussie E Ruiz G Wheeler L A and Schwartz M | 2001 | Proc Natl Aead Sci U S A2001，，98： | 1 |
| 20 | Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension显示文摘 | WOLDEMUSSIE E RUIZ G WIJONO M | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
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