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| 1 | Severe ulcerative colitis: At what point should we define resistance to steroids?显示文摘Corticoesteroids are still the first-line treatment for active ulcerative colitis more than 50 years after the publication of trials assessing their beneficial effect, with about a 50% remission rate in cases of severe disease. The mortality related to severe attacks of ulcerative colitis has decreased dramatically, to less than 1%, in experienced centers, due to the appropriate use of intensive therapeutic measures (intravenous steroids, fluids and electrolytes, artificial nutritional support, antibiotics, etc), along with timely decision-making about second-line medical therapy and early identification of patients requiring colectomy. One of the most difficult decisions in the management of severe ulcerative colitis is knowing for how long corticosteroids should be administered before deciding that a patient is a non-responder. Studies assessing the outcome of acute attacks after steroid initiation have demonstrated that, in steroid-sensitive patients, the response generally occurs early on, in the first days of treatment. Different indexes to predict treatment failure, when applied on the third day of treatment, have demonstrated a high positive predictive value for colectomy. In contrast to this resolute approach, which is the most widely accepted, other authors have suggested that in some patients a completeand prolonged response to steroids may take longer. Either way, physicians taking care of these patients need to recognize that severe ulcerative colitis may be life-threatening, and they need to be careful with excessively prolonged medical treatment and delayed surgery. | Maria Esteve Javier P Gisbert | 2008 | World Journal of Gastroenterology2008，14，36： | 3 |
| 2 | A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities显示文摘 | M C Garcia P Puchalska C Esteve | 2013 | Talanta2013，106，： | 1 |
| 3 | Mechanical proper- ties of cement mortars with superabsorbent polymers 显示文摘 | Esteves LP Cachim P Ferreira VM | 2007 | Advances in Construction Materials2007，，： | 1 |
| 4 | Report on Repeated Mifepristone Treatment for Uterine Fibroids or Endometriosis 显示文摘 | JL C Esteve A Rita P Yasmirian | 2013 | Journal of Clinical Gynecology and Obstetrics2013，2，1： | 1 |
| 5 | The Netrin - related domain of sfrpl interacts with Wnt ligands and antagonizes their activity in the anterior neural plate 显示文摘 | Lopez - Rios J Esteve P Ruiz JM | 2008 | Neural Develop2008，1，： | 1 |
| 6 | lnfluence of deposition pressure on the structural mechanical and decorative properties of TiN thin films deposited by cathodic arc evaporation显示文摘 | A Lousa J Esteve J P Mejia | 2007 | Vacuum2007，81，1112： | 1 |
| 7 | Be- yond Wnt inhibition: new functions of secreted Friz- zled-related proteins in development and disease显示文摘 | BOVOLENTA P ESTEVE P RUIZ J M | 2008 | J Cell Sci2008，121，： | 1 |
| 8 | Production of oligosaccharides by autohydrolysis of brewery's spent grain显示文摘 | CARVALHEIRO F ESTEVES M P PARAJO J C | 2004 | Bioresoure Technol2004，91，1： | 1 |
| 9 | Gene expression profiling of acute myeloid leukemia wit h t ranslocation t ( 8 ; 16 ) (p11 ; p13 ) and MYST3- CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression显示文摘 | Camos M Esteve J Jares P | 2006 | Cancer Res2006，66，14： | 1 |
| 10 | Rheoiogy and hardened properties of single-coat render mortars with different types of water retaining agents 显示文摘 | Paiva I4 Esteves L P Cachim P B el al | 2009 | Construction and Building Materials2009，23，2： | 1 |
| 11 | Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5 显示文摘 | Corddier P Esteve JP Bousquet C | 1997 | Proc Nad Acad Sci USA1997，94，17： | 1 |
| 12 | Bacteremia related with arterial catheter in critically ill patients显示文摘 | Esteve F Pujol M Pérez XL | 2011 | J Infect2011，63，2： | 1 |
| 13 | Design,fabrication and characterization of a MEMS safe pyrotechnical igni-ter integrating arming,disarming and sterilization functions显示文摘 | PENNARUN P ROSSI C ESTEVE D | 2006 | Journal of Micromechanics and Microengineering2006，16，1： | 1 |
| 14 | Beyond Wnt inhi- bition: new functions of secreted Frizzled-related proteins in development and disease显示文摘 | Bovolenta P Esteve P Ruiz JM | 2008 | J Cell Sci2008，121，6： | 1 |
| 15 | Processes for the elimination of estrogenic steroid hormones from water: a review 显示文摘 | Silva C P Otero M Esteves V | 2012 | Environmental Pollution2012，165，： | 1 |
| 16 | Processes for the elimination of estrogenic steroid hormones from water:a review显示文摘 | Silva C P Otero M Esteves V | 2012 | Environmental Pollution2012，165，： | 1 |
| 17 | Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial显示文摘 | Josep Ll. Carbonell Esteve Rita Acosta Yasmiriam Pérez Rosa Campos Aleta Valle Hernández Carlos Sánchez Texidó | 2012 | European Journal of Obstetrics and Gynecology2012，，2： | 1 |
| 18 | Comparative study of electron mediators used in the electrochemical oxidation of NADH显示文摘 | Beatriu P S Esteve F | 2004 | Biosens Bioelectron2004，19，10： | 1 |
| 19 | Gene expression profiling of acute myeloid leukemia with translocation t (8: 16) (p11; p13) and MYST3 CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression 显示文摘 | Camos M Esteve J Jares P | 2006 | CancerRes2006，66，14： | 1 |
| 20 | Ectopic be- ta-chain of ATP synthase is an apolipoprotein A-I receptor in he- patic HDL endocytosis 显示文摘 | MARTINEZ L O JACQUET S ESTEVE J P | 2003 | Nature2003，421，6918： | 1 |
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