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| 1 | Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats显示文摘AIM: To study the effects of centrophenoxine (CPH, meclofenoxate) on chronic cerebral hypoperfusion induced deficits in rats. METHODS: Chronic hypoperfusion in rats was performed by permanent bilateral ligation of the common carotid arteries. Morris water maze was used to measure spatial memory performance. Spectrophoto- metrical techniques were used to assay SOD, GPx activities, MDA content, TXB2, and 6-keto-PGF1α levels. Mor- phological change was examined by HE staining. The expression of Bax and p53 protein were assayed by immuno- histochemistry analysis. RESULTS: Chronic hypoperfusion in rats resulted in spatial memory impairments shown by longer escape latency and shorter time spent in the target quadrant. These behavioral dysfunction were accom- panied by increase in SOD and GPx activities, the content of MDA, the levels of pro-inflammatory mediators (TXB2, 6-keto-PGF1α), overexpression of Bax and P53 protein, and delayed degeneration of neurons in cortex and hippocampus. Oral administration of CPH (100 mg/kg, once per day for 37 d) markedly improved the memory impairment, reduced the increase in antioxidant enzyme activities, MDA content and the levels of pro-inflammatory mediators to their normal levels, and attenuated neuronal damage. CONCLUSION: The abilities of CPH to attenu- ate memory deficits and neuronal damage after ischemia may be beneficial in cerebrovascular type dementia. | YunLIA RuiWANG Xi-canTANG | 2004 | Acta Pharmacologica Sinica2004，25，12： | 18 |
| 2 | Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China显示文摘AIM: To investigate the association between single nucleotide polymorphism (SNP)in promoter of the DNA methyltransferase 3B (DNNT3B) gene and risk for development and lymphatic metastasis of gastric cardiac adenocarcinoma (GCA).METHODS: The hospital based case-control study included 212 GCA patients and 294 control subjects without overt cancer. The DNMT3B SNP was genotyped by PCR and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The C/C genotype was not detected in both GCA patients and controls. In control subjects, the frequency of T/T and C/T genotypes was 94.9% and 5.1% respectively,and that of T and C alleles was 97.4% and 2.6%, respectively.The genotype and allelotype distribution in the GCA patients was not significantly different from that in controls (P = 0.34 and 0.33, respectively). When stratified by smoking status and family history of upper gastrointestinal cancer, significant difference in the genotype distribution was not observed between GCA patients and controls. The distribution of DNMT3Bgenotypes in GCA patients with or without lymphatic metastasis did not show significant difference (P = 0.42). CONCLUSION: The distribution of DNMT3BSNP in North China is distinct from that in Caucasians. Although this SNP has been associated with susceptibility to lung, head, neck and breast cancer, it may not be used as a stratification marker to predict susceptibility and lymphatic metastasis of GCA, at least in the population of North China. | Yi-MinWang RuiWang Deng-GuiWen YanLi WeiGuo NaWang Li-ZhenWei Yu-TongHe Zhi-FengChen Xiu-FengZhang Jian-HuiZhang | 2005 | World Journal of Gastroenterology2005，11，23： | 11 |
| 3 | 多胺对大鼠缺氧-复氧心肌细胞内钙的影响显示文摘目的:观察外源性低浓度多胺对大鼠缺氧-复氧心肌细胞钙超载的影响。方法:酶解分离大鼠心室 肌细胞,用正常氧合Tyrode液灌流8 min,换为缺氧液灌流32 min,再转换为正常氧合Tyrode液灌流8 min,复制心肌 缺氧-复氧模型。分别在缺氧前给予精胺,缺氧-复氧后给予精胺、精脒、腐胺。应用激光扫描共聚焦显微镜 (LSCM)连续观察细胞内钙荧光强度的动态变化。结果:精胺(1 mol/L)对正常静息状态下大鼠心室肌[Ca2+]i无影 响。缺氧前给予精胺,可取消复氧引起的心肌[Ca2+]i增高;缺氧-复氧后给予精胺、精脒、腐胺对缺氧-复氧引起 [Ca2+]i升高也有不同程度的降低作用,其中以精胺的作用最强。复氧后给予精胺降低缺氧-复氧[Ca2+]i升高的 作用小于缺氧前给予。结论:缺氧前给予精胺可拮抗缺氧-复氧心肌细胞钙超载发生;复氧后给予精胺可使缺氧- 复氧心肌细胞钙超载减轻,但其作用力度不如缺氧前给药。多胺拮抗缺氧-复氧心肌细胞钙超载的作用以精胺> 精脒>腐胺的顺序递减。 | 赵雅君 徐长庆 时飒 孙宏力 王宁 李宝馨 王玲 杨宝峰 RuiWang | 2005 | 中国病理生理杂志2005，21，10： | 10 |
| 4 | 大鼠心肌钙敏感受体蛋白的表达及其与心肌细胞凋亡的关系显示文摘目的观察大鼠心肌组织和心肌细胞钙敏感受体(CaSR)蛋白表达与心肌细胞凋亡及相关信号传导途径的关系。方法Western blot检测心肌CaSR蛋白和ERK1/2、BCl2及Caspase3的表达。免疫荧光和流式细胞仪观察细胞凋亡。结果心肌组织和心肌细胞表面可检测到CaSR蛋白的表达。CaSR激动剂氯化钆(GdCl3)能促进心肌细胞凋亡,并使ERK1/2的磷酸化增加、BCl2表达及Caspase3活化。加入酪氨酸蛋白激酶阻断剂PD98059后,心肌细胞凋亡率增加,ERK1/2磷酸化降低,BCl2表达消失,Caspase3活化增强。结论CaSR蛋白在心肌细胞膜表面表达,其激活通过Caspase 3活化,促进心肌细胞凋亡。同时亦可激活酪氨酸蛋白激酶途径。 | 孙轶华 徐长庆 李弘 时飒 张伟华 赵雅君 张艳桥 韩伟民 韩丽萍 姜春明 李全凤 RuiWANG | 2006 | 中华心血管病杂志2006，34，8： | 8 |
| 5 | No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China显示文摘AIM: To investigate association of the 2G or 1G single nudeotide polymorphism (SNP)in matrix metalloproteinase 11(MMP1)promoter with susceptibility to esophageal squam-ous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of North China.METHODS: MMP1 promoter SNP was genotyped by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 417 cancer patients (234ESCC and 183 GCA) and 350 healthy controls.RESULTS: The genotype frequencies of the MMP1promoter SNP in healthy controls were 55.4% (2G/2G),30% (1G/2G) and 14.6% (1G/1G), respectively. The genotype and allelotype distribution in ESCC and GCA patients was not significantly different from that in healthy controls (all Pvalues were above 0.05). Compared with the 1G/1G genotype, neither the 2G/2G nor in combination with the 1G/2G genotype significantly modified the risk of developing ESCC and GCA, the adjusted odds ratio was 1.28 (95%CI = 0.78-2.09), 1.23 (95%CI = 0.38-2.05)in ESCC and 1.39 (95%CI = 0.80-2.41), 1.34 (95%CI =0.74-2.40) in GCA, respectively. When stratified by smoking status and family history of upper gastrointestinal cancer, the 2G/2G genotype alone or in combination with the 1G/2G genotype also did not show any significant influence on the risk of ESCC and GCA development. In addition, influence of the MMP1 SNP on lymphatic metastasis in ESCC and GCA was also not obs-erved.CONCLUSION: The 2G or 1G SNP in the MMP1 promoter might not modify the risk of ESCC and GCA development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types. | XiaJin GangKuang Li-ZhenWei YanLi RuiWang WeiGuo NaWang Shu-MeiFang Zhi-FengChen Jian-HuiZhang | 2005 | World Journal of Gastroenterology2005，11，16： | 7 |
| 6 | Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells显示文摘Aim: To study the effects of huperzine A (HupA) on neuritogenic activity and the expression of nerve growth factor (NGF). Methods: After being treated with 10μmol/L HupA, neurite outgrowth of PC 12 cells was observed and counted under phase-contrast microscopy. Mitogenic activity was assayed by [^3H]thymidine incorporation. Cell cytotoxicity was evaluated by lactate dehydrogenase (LDH) release. AChE activity, mRNA and protein expression were measured by the Ellman's method, RT-PCR, and Western blot, respectively. NGF mRNA and protein levels were determined by RT-PCR and ELISA assays. Results: Treatment of PC 12 cells with 10μmol/L HupA for 48 h markedly increased the number of neuritebearing cells, but caused no significant alteration in cell viability or other signs of cytotoxicity. In addition to inhibiting AChE activity, 10μmol/L HupA also increased the mRNA and protein levels of this enzyme. In addition, following 2h exposure of the astrocytes to 10μmol/L HupA, there was a significant up-regulation of mRNA for NGF and P75 low-affinity NGF receptor. The protein level of NGF was also increased after 24 h treatment with HupA. Conclusion: Our findings demonstrate for the first time that HupA has a direct or indirect neurotrophic activity, which might be beneficial in treatment of neurodegenerative disorders such as Alzheimer disease. | Li-liTANG RuiWANG Xi-canTANG | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 7 | Luminescent properties of Dy^3+/Eu^3+ doped fluorescent glass for white LED based on oxyfluoride matrix显示文摘Rare earth ion-doped fluorescent glass has become a hotspot due to its characteristics.This work shows that the prepared Dy^3+and Dy^3+/Eu^3+doped glasses have white light emission under ultraviolet excitation.There is a higher yellow light/blue light(Y/B)value,indicating an increase in the covalentity of Dy-O,and decrease in the symmetry with the increasing concentration of dopants(Dy^3+).The correlated color temperature(CCT)can be effectively reduced by the red light emission of Eu^3+,and the order of influence of excitation wavelength on CCT is 395 nm>382 nm>365 nm.The delay curve demonstrates the energy transfer from Dy^3+to Eu^3+.The glass has the characteristics of anti-blue light damage and wide tunable color temperature,which illustrates that it has potential application in the field of white LED. | Jingxi An Shuang Zhang Ruiwang Liu Guangxu Hu Zhiwei Zhang Yiyu Qiu Yanyan Zhou Fanming Zeng Zhongmin Su | 2021 | Journal of Rare Earths2021，39，1： | 5 |
| 8 | Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness显示文摘A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions.However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections(ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls.Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level. | Ping Chen Qiuyou Xie Xiaoyan Wu Huiyuan Huang Wei Lv Lixiang Chen Yequn Guo Shufei Zhang Huiqing Hu You Wang Yangang Nie Ronghao Yu Ruiwang Huang | 2018 | Neuroscience Bulletin2018，34，4： | 4 |
| 9 | Epoxide hydrolase Tyr113 His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China显示文摘AIM: To investigate the possible association of microsomal epoxide hydrolase ( mEH) Tyr113 His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North China.METHODS: The mEH-Tyr113 His genotypes were determined by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 257 patients with esophageal squamous cell carcinoma (ESCC) and 252 healthy subjects as a control group.RESULTS: The frequencies for Tyr and His alleles were 44.2 %, 55.8 % in ESCC patients, and 44.0 % and 56.0 %in healthy subjects, respectively. No statistic difference in allele distribution was observed between ESCC patients and controls (x2=0.008, P=0.929). The overall genotype distribution difference was not observed between cancer cases and controls (x2=2.116, P=-0.347). Compared with Tyr/Tyr genotype, neither His/His genotype nor in combination with Tyr/His genotype significantly modified the risk of the development of ESCC, the adjusted odds ratio was 1.076 (95 % CI=0.850-1.361) and 0.756 (95 % CI=0.493-1.157),respectively. When stratified for sex, age, smoking status and family history of upper gastrointestinal cancer, His/His genotype alone or in combination with Tyr/His genotype also did not show any significant influence on the risk of developing ESCC.CONCLUSION: MEH Tyr113His polymorphism may not be used as a stratification marker in screening individuals at a high risk of ESCC. | Jian-HuiZhang XiaJin YanLi RuiWang WeiGuo NaWang Deng-GuiWen Zhi-FengChen GangKuang Li-ZhenWei Shi-JieWang | 2003 | World Journal of Gastroenterology2003，9，12： | 2 |
| 10 | Increased expression of calcium‐sensing receptors induced by ox‐LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia–reperfusion显示文摘 | JinGuo Hong‐ZhuLi Wei‐HuaZhang Lu‐ChuanWang Li‐NaWang LiZhang Guang‐WeiLi Hong‐XiaLi Bao‐FengYang LingyunWu RuiWang Chang‐QingXu | 2010 | Clinical and Experimental Pharmacology and Physiology2010，，3： | 1 |
| 11 | Irreversible Exocrine Pancreatic Insufficiency in Alcoholic Rats Without Chronic Pancreatitis After Alcohol Withdrawal显示文摘 | JingLi ChaoZhou RuiWang RuiLiu ZhiyinHuang ChengweiTang | 2010 | Alcoholism: Clinical and Experimental Research2010，，11： | 1 |
| 12 | Increased expression of calcium‐sensing receptors induced by ox‐LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia–reperfusion显示文摘 | JinGuo Hong‐ZhuLi Wei‐HuaZhang Lu‐ChuanWang Li‐NaWang LiZhang Guang‐WeiLi Hong‐XiaLi Bao‐FengYang LingyunWu RuiWang Chang‐QingXu | 2010 | Clinical and Experimental Pharmacology and Physiology2010，，3： | 1 |
| 13 | Integrin β3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer显示文摘 | RUIWANG ZHAO‐QINGLI XUHAN BAI‐LINLI XIAO‐YIMI LI‐MEISUN MINSONG YAN‐CHUNHAN YANZHAO EN‐HUAWANG | 2010 | APMIS2010，，12： | 1 |
| 14 | Temperature dependence of the exchange field of R2Fe14B compounds 显示文摘 | Zhang Zhongwu Huang Ruiwang | 1992 | Journal of Alloys and Compounds1992，185，： | 1 |
| 15 | Land use change and economic growth in urban China: A structural equation analysis显示文摘 | Canfei He Zhiji Huang RuiWang | 2014 | Urban Studies2014，51，13： | 1 |
| 16 | Air sensitivity of electrode materials in Li/Na ion batteries:Issues and strategies显示文摘With the development of electrode materials in lithium ion batteries-upgrading from LiCoO_(2)and LiFePO_(4)to Ni-rich layered oxides,and the shifting of battery systems from high cost lithium ion to low cost sodium ion technology,the air sensitivity of the electrode materials has become an increasingly important issue in both production and application.Furthermore,the air sensitivity of electrode materials must be carefully considered throughout nearly all stages of their life,including material design,synthesis,production,storage,packaging,transportation,and battery assembly.Therefore,a fundamental understanding of the air degradation mechanism of electrode materials and the exploration of new methods to enhance their air stability are of great significance for the development of batteries with better performance.Herein,we provide a review of the issues related to air exposure of electrode materials in Li/Na ion batteries,including factors related to air sensitivity,degradation mechanisms,and recent progress in improving their air stability.The merits and existing challenges of different strategies are presented,and a rational design perspective as well as general principles for evaluating air stability are proposed. | Ruiwang Zhang Sijie Yang Haobo Li Tianyou Zhai Huiqiao Li | 2022 | InfoMat2022，4，6： | 1 |
| 17 | Proteomic response of Phaeocystis globosa to nitrogen limitation显示文摘Phaeocystis globosa is an important unicellular eukaryotic alga that can also form colonies.P.globosa can cause massive harmful algal blooms and plays an important role in the global carbon or sulfur cycling.Thus far,the ecophysiology of P.globosa has been investigated by numerous studies.However,the proteomic response of P.globosa to nitrogen depletion remains largely unknown.We compared four protein preparation methods of P.globosa for two-dimensional electrophoresis(2-DE)(Urea/Triton X-100 with trichloroacetic acid(TCA)/acetone precipitation;TCA/acetone precipitation;Radio Immuno Precipitation Assay(RIPA)with TCA/acetone precipitation;and Tris buffer).Results show that the combination of RIPA with TCA/acetone precipitation had a clear gel background and showed the best protein spot separation effect,based on which the proteomic response to nitrogen depletion was studied using 2-DE.In addition,we identified six differentially expressed proteins whose relative abundance increased or decreased more than 1.5-fold(P<0.05).Most proteins could not be identified,which might be attributed to the lack of genomic sequences of P.globosa.Under nitrogen limitation,replication protein-like,RNA ligase,and sn-glycerol-3-phosphate dehydrogenase were reduced,which may decrease the DNA replication level and ATP production in P.globosa cells.The increase of endonucleaseⅢand transcriptional regulator enzyme may affect the metabolic and antioxidant function of P.globosa cells and induce cell apoptosis.These findings provide a basis for further proteomic study of P.globosa and the optimization of protein preparation methods of marine microalgae. | Haisu LIU Ruiwang WEI Qiangyong LEI Lei CUI Songhui LÜ | 2024 | Journal of Oceanology and Limnology2024，42，1： | 0 |
| 18 | Foldable high-strength electrode enabled by nanosheet subunits for advanced sodium-ion batteries显示文摘Power sources with strong mechanical properties and high-energy density are highly desirable for the next-generation flexible electronics.However,the challenge arises from the current electrode structure design,which is unable to bring both satisfactory mechanical and electrochemical properties with high active materials content and mass.Herein,we reported novel flexible,highstrength,and mechanically stable TiO_(2)-based film electrodes for advanced sodium-ion batteries,achieving an ultrahigh strength(up to≈60 MPa)and commercial-level areal capacity(4.5 mAh cm^(-2)).Highly-dispersed TiO_(2) and interlaced carbon nanotube(CNT)networks are embedded in the sheet-liked cellulose to form porous,high-conductive,and high-active TiO_(2)-C nanosheets that is basic building subunits of TiO_(2)-C films,allowing the films with structural robustness and origami-level flexibility.This strategy reconciles the contradiction between mechanical properties and active material content in flexible electrodes,and the fabricated electrode with a high TiO_(2) content of>65%can be bent more than 11000 times without breaking.Meanwhile,good capacity and excellent cycle stability(0.02‰capacity-decay rate over 9000 cycles)of TiO_(2)-C film under a higher active content(75%)has well satisfied the demands of flexible energy storage devices for electrochemical performances.This TiO_(2)-C subunit assembly methodology demonstrates enormous potential in high-strength/toughness flexible electrode construction for flexible electronics. | Hanwei Wang Jinzhou Fu Chao Wang Ruiwang Zhang Yingying Li Yushan Yang Haobo Li Qingfeng Sun Huiqiao Li | 2022 | InfoMat2022，4，2： | 0 |
| 19 | Improvement of Binocular Reconstruction Algorithm for Measuring 3D Pavement Texture Using a Single Laser Line Scanning Constraint显示文摘The dense and accurate measurement of 3D texture is helpful in evaluating the pavement function.To form dense mandatory constraints and improve matching accuracy,the traditional binocular reconstruction technology was improved threefold.First,a single moving laser line was introduced to carry out global scanning constraints on the target,which would well overcome the difficulty of installing and recognizing excessive laser lines.Second,four kinds of improved algorithms,namely,disparity replacement,superposition synthesis,subregion segmentation,and subregion segmentation centroid enhancement,were established based on different constraint mechanism.Last,the improved binocular reconstruction test device was developed to realize the dual functions of 3D texture measurement and precision self-evaluation.Results show that compared with traditional algorithms,the introduction of a single laser line scanning constraint is helpful in improving the measurement’s accuracy.Among various improved algorithms,the improvement effect of the subregion segmentation centroid enhancement method is the best.It has a good effect on both overall measurement and single pointmeasurement,which can be considered to be used in pavement function evaluation. | Yuanyuan Wang RuiWang Xiaofeng Ren Junan Lei | 2023 | Computer Modeling in Engineering & Sciences2023，，8： | 0 |
| 20 | Analysis on appendicitis of 2000 patients in clinical anatomy显示文摘 | JianCao BinMeng BoZhang YingquanLi RuiWang MingzhiCheng WeiTao JunHu BoLiang DishengMeng DaweiLi YongLuo GeyangXu | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
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