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| 1 | Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China显示文摘AIM: To investigate the possible association of G→A single nucleotide polymorphism (SNP) at the -1082 position of interleukin (IL)-10 promoter with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of a high incidence region of North China.METHODS: IL-10-G1082A promoter SNP was genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) in 355 cancer patients (203ESCC and 152 GCA) and 443 healthy controls.RESULTS: Smoking significantly increased the risk of ESCC and GCA development (the age and sex adjusted OR = 1.42and 2.64, 95%CI = 1.11-1.81 and 1.46-4.76, respectively).Similarly, family history of upper gastrointestinal cancer (UGIC) significantly increased the risk of developing ESCC and GCA (the age and sex adjusted OR = 1.44 and 3.10,95%CI = 1.18-1.75 and 1.94-4.97, respectively). The A/A, A/G and G/G genotype frequencies of IL-10-G1082A were 60.3%, 37.0% and 2.7% in healthy controls, 57.6%,39.9% and 2.5% in ESCC and 61.2%, 36.8% and 2.0% in GCA patients, respectively. The frequencies of A and G alleles were 78.8% and 21.2% in healthy controls, 77.6%and 22.4% in ESCC patients and 79.6%, 20.4% in GCA patients. The distribution of genotype and allelotype in ESCC and GCA patients was not significantly different from that in healthy controls (P>0.05). Compared to the A/A genotype, the combination of A/G and G/G genotypes did not show a significant effect on the risk of developing ESCC and GCA; the adjusted odds ratio was 0.92 (95%CI = 0.76-1.11) in ESCC and 0.95 (95% CI = 0.61-1.46)in GCA, respectively. When stratified for smoking status and family history of UGIC, the combination of A/G and G/G genotypes also did not show any significant influence on the risk of ESCC and GCA development compared to A/A genotypes.CONCLUSION: IL-10-G1082A polymorphism might not be used as a stratification marker to predicate the risk of ESCC and GCA development in North China. | WeiGuo NaWang Yi-MinWang YanLi Deng-GuiWen Zhi-FengChen Yu-TongHe Jian-HuiZhang | 2005 | World Journal of Gastroenterology2005，11，6： | 25 |
| 2 | Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China显示文摘AIM: To investigate the association between single nucleotide polymorphism (SNP)in promoter of the DNA methyltransferase 3B (DNNT3B) gene and risk for development and lymphatic metastasis of gastric cardiac adenocarcinoma (GCA).METHODS: The hospital based case-control study included 212 GCA patients and 294 control subjects without overt cancer. The DNMT3B SNP was genotyped by PCR and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The C/C genotype was not detected in both GCA patients and controls. In control subjects, the frequency of T/T and C/T genotypes was 94.9% and 5.1% respectively,and that of T and C alleles was 97.4% and 2.6%, respectively.The genotype and allelotype distribution in the GCA patients was not significantly different from that in controls (P = 0.34 and 0.33, respectively). When stratified by smoking status and family history of upper gastrointestinal cancer, significant difference in the genotype distribution was not observed between GCA patients and controls. The distribution of DNMT3Bgenotypes in GCA patients with or without lymphatic metastasis did not show significant difference (P = 0.42). CONCLUSION: The distribution of DNMT3BSNP in North China is distinct from that in Caucasians. Although this SNP has been associated with susceptibility to lung, head, neck and breast cancer, it may not be used as a stratification marker to predict susceptibility and lymphatic metastasis of GCA, at least in the population of North China. | Yi-MinWang RuiWang Deng-GuiWen YanLi WeiGuo NaWang Li-ZhenWei Yu-TongHe Zhi-FengChen Xiu-FengZhang Jian-HuiZhang | 2005 | World Journal of Gastroenterology2005，11，23： | 11 |
| 3 | No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China显示文摘AIM: To investigate association of the 2G or 1G single nudeotide polymorphism (SNP)in matrix metalloproteinase 11(MMP1)promoter with susceptibility to esophageal squam-ous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of North China.METHODS: MMP1 promoter SNP was genotyped by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 417 cancer patients (234ESCC and 183 GCA) and 350 healthy controls.RESULTS: The genotype frequencies of the MMP1promoter SNP in healthy controls were 55.4% (2G/2G),30% (1G/2G) and 14.6% (1G/1G), respectively. The genotype and allelotype distribution in ESCC and GCA patients was not significantly different from that in healthy controls (all Pvalues were above 0.05). Compared with the 1G/1G genotype, neither the 2G/2G nor in combination with the 1G/2G genotype significantly modified the risk of developing ESCC and GCA, the adjusted odds ratio was 1.28 (95%CI = 0.78-2.09), 1.23 (95%CI = 0.38-2.05)in ESCC and 1.39 (95%CI = 0.80-2.41), 1.34 (95%CI =0.74-2.40) in GCA, respectively. When stratified by smoking status and family history of upper gastrointestinal cancer, the 2G/2G genotype alone or in combination with the 1G/2G genotype also did not show any significant influence on the risk of ESCC and GCA development. In addition, influence of the MMP1 SNP on lymphatic metastasis in ESCC and GCA was also not obs-erved.CONCLUSION: The 2G or 1G SNP in the MMP1 promoter might not modify the risk of ESCC and GCA development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types. | XiaJin GangKuang Li-ZhenWei YanLi RuiWang WeiGuo NaWang Shu-MeiFang Zhi-FengChen Jian-HuiZhang | 2005 | World Journal of Gastroenterology2005，11，16： | 7 |
| 4 | Epoxide hydrolase Tyr113 His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China显示文摘AIM: To investigate the possible association of microsomal epoxide hydrolase ( mEH) Tyr113 His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North China.METHODS: The mEH-Tyr113 His genotypes were determined by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 257 patients with esophageal squamous cell carcinoma (ESCC) and 252 healthy subjects as a control group.RESULTS: The frequencies for Tyr and His alleles were 44.2 %, 55.8 % in ESCC patients, and 44.0 % and 56.0 %in healthy subjects, respectively. No statistic difference in allele distribution was observed between ESCC patients and controls (x2=0.008, P=0.929). The overall genotype distribution difference was not observed between cancer cases and controls (x2=2.116, P=-0.347). Compared with Tyr/Tyr genotype, neither His/His genotype nor in combination with Tyr/His genotype significantly modified the risk of the development of ESCC, the adjusted odds ratio was 1.076 (95 % CI=0.850-1.361) and 0.756 (95 % CI=0.493-1.157),respectively. When stratified for sex, age, smoking status and family history of upper gastrointestinal cancer, His/His genotype alone or in combination with Tyr/His genotype also did not show any significant influence on the risk of developing ESCC.CONCLUSION: MEH Tyr113His polymorphism may not be used as a stratification marker in screening individuals at a high risk of ESCC. | Jian-HuiZhang XiaJin YanLi RuiWang WeiGuo NaWang Deng-GuiWen Zhi-FengChen GangKuang Li-ZhenWei Shi-JieWang | 2003 | World Journal of Gastroenterology2003，9，12： | 2 |
| 5 | Regioselective Synthesis of Polymerizable Vinyl Guaifenesin Esters Catalyzed by an Alkaline Protease of Bacillus subtilis显示文摘Three polymerizable vinyl guaifenesin esters with different acyl donor carbon chain lengths (C4,C6,C10) were regioselectivly synthesized by an alkaline protease from Bacillus subtilis in pyridine at 50C for 1, 3, 5 days respectively. | NaWANG QiWU JianMingXU XiuMingJIANG XianFuLIN | 2004 | Chinese Chemical Letters2004，15，2： | 1 |
| 6 | RECENT RESEARCH ON LADAKH 6-Proceeding of the sixth international colloquiurm on ladakh leh 1993显示文摘 | | 1997 | DELHI:MOTILAL BANARSIDASS PUBLISHERS PRIVATE LIMITED1997，，16： | 1 |
| 7 | Antimi-crobial effects of thaimedicinal plants against acne-inducing bacte-ria显示文摘 | Chom nawang MT Surassmo S Nukoolkam VS | 2005 | J Ethnopharmacol2005，101，13： | 1 |
| 8 | A Large Glitch in the Crab Pulsar显示文摘Using a new pulsar timing system at the 25-m radio telescope of Urumqi Astronomical Observatory, we have detected a large glitch in the Crab pulsar which occurred in 2000 July. The size of the gfitch is Av/v ~ 2.4 × 10-8, with a rela tive increment in frequency derivative Av/v ~ 5 × 10-3. The observing system is introduced and the observed properties of the glitch are discussed. | NaWang Xin-JiWu 等 | 2001 | Chinese Journal of Astronomy and Astrophysics2001，1，3： | 1 |
| 9 | RECENT RESEARCH ON LADAKH 6-Proceeding of the sixth international colloquiurm on ladakh leh 1993显示文摘 | HENRY OSMASTON NAWANG TSERING | 1997 | DELHI:MOTILAL BANARSIDASS PUBLISHERS PRIVATE LIMITED1997，，： | 1 |
| 10 | Increased expression of calcium‐sensing receptors induced by ox‐LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia–reperfusion显示文摘 | JinGuo Hong‐ZhuLi Wei‐HuaZhang Lu‐ChuanWang Li‐NaWang LiZhang Guang‐WeiLi Hong‐XiaLi Bao‐FengYang LingyunWu RuiWang Chang‐QingXu | 2010 | Clinical and Experimental Pharmacology and Physiology2010，，3： | 1 |
| 11 | Prevalence and asso- ciated factors of depressive symptoms among Chinese doctors A cross - sectional survey 显示文摘 | Jia - NaWang Wei Sun Tie - Shuang Chi | 2010 | Int Arch Occup Environ Health2010，83，8： | 1 |
| 12 | Increased expression of calcium‐sensing receptors induced by ox‐LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia–reperfusion显示文摘 | JinGuo Hong‐ZhuLi Wei‐HuaZhang Lu‐ChuanWang Li‐NaWang LiZhang Guang‐WeiLi Hong‐XiaLi Bao‐FengYang LingyunWu RuiWang Chang‐QingXu | 2010 | Clinical and Experimental Pharmacology and Physiology2010，，3： | 1 |
| 13 | Mechanical properties of sago starch-filled linear low density polyethylene (LLDPE) composites 显示文摘 | Nawang R Danjaji I D Ishiaku U S | 2001 | Polymer Testing2001，20，： | 1 |
| 14 | 显示文摘 | Danjaji I D Nawang R Ishiaku U S el al | 2002 | Polymer Tes ring2002，2，1： | 1 |
| 15 | 显示文摘 | Nawang R Danjaji I D Ishiaku U S | 2001 | Material Proper ties2001，20，2： | 1 |
| 16 | Regiospecific Addition of Uracil to Acrylates Catalyzed by Alkaline Protease from Bacillus subtilis显示文摘Michael addition reactions of uracil to acrylates were catalyzed by an alkaline protease from Bacillus subtilis in dimethyl sulfoxide at 55 ℃ for 72 h. The adducts were determined by TLC, IR and 1H NMR. | YingCAI JianYiWU NaWANG XiaoFengSUN XianFuLIN | 2004 | Chinese Chemical Letters2004，15，5： | 0 |
| 17 | Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol: Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic显示文摘Three polymerizable vinyl thiamphenicol esters with different acyl donor carbon chain length (C4, C6, C10) were regioselectivly synthesized by Lipozyme? (immobilized from mucor miehei) in acetone at 50 oC for 12 h to give 73%, 81%, 63% yield, respectively. The products were valuable monomers for preparation of macromolecular antibiotic. | YuZhenSHI ZhiChunCHEN NaWANG QiWU XianFuLIN | 2005 | Chinese Chemical Letters2005，16，1： | 0 |
| 18 | CARDIAC RISK STRATIFICATION IN PATIENTS WITH CONGESTIVE HEART FAILURE:A CATECHOLAMINES-β-ADRENOCEPTOR-cAMP PATHWAY显示文摘Objective To investigate the stratification risk of catecholamines-β-adrenoceptor (β-AR)-cAMP pathway for cardiogenic death events in patients with congestive heart failure (CHF). Methods A total of 83 identified CHF patients with a baseline and follow-up plasma levels of norepinephrine (NE) and epinephrine (E), lymphocytes β-AR density (Bmax), and intralymphocyte cAMP content in peripheral blood were followed up. Major cardiogenic death events were registered. Results The period between the initial entry and the last follow-up measurement were 51±16 months, the total duration of clinical follow-up after the last measurement were 14±8 months. During follow-up, 39 patients died of cardiogenic (sudden death 17 patients, worsening heart failure 22 patients). Persistence of high NE, E, and cAMP from baseline to follow-up were confirmed as risk predicting factors of cardiovascular events. Persistence NE above 4.0 nmol/L, E above 3.5 nmol/L, and the intralymphocyte cAMP content above 3.5 pmd·mg-1·pro-1 from baseline to follow-up were significant adverse prognostic predictors. The major cardiogenic death events rates per 100 patients-years were 1.33 and 4.82 in patients with NE below and above 4.0 nmol/L (HR: 2.91; 95% CI: 1.08-7.33; P = 0.015); were 1.42 and 4.36 in the patients with E levels below and above 3.5 nmol/L (HR: 2.64; 95% CI: 1.02-6.41; P = 0.019); were 1.81 and 4.67 in the patients with the intralymphocyte cAMP content below and above 3.5 pmd·mg-1·pro-1 (HR: 2.79; 95% CI: 1.04-6.83; P = 0.017), but difference was not significant between the β-AR density below and above median. Conclusions Persistent increase in circulating catecholamines and intralymphocyte cAMP content may increase the long-term mortality in CHF patients. | Ying-xinPeng JiangShan Su-junZhang Chun-liRong Jun-pingLi NaWang HaoXue Shi-lingZheng MinWu | 2005 | Chinese Medical Sciences Journal2005，20，2： | 0 |
| 19 | Scintillation Dynamic Spectra and Transverse Velocities ofSeven Pulsars显示文摘Using a pulsar timing system developed at Urumqi Astronomical Observatory’s 25-m telescope, we observed scintillation dynamic spectra for seven pulsars at the relatively high frequency of 1540 MHz over a wide frequency band of 320 MHz. Averaging observations at different epochs, we obtain time scales and decorrelation bandwidths for diffractive scintillation and show that these imply a power-law index for the electron density fluctuation close to 4.0. Assuming this value and that the scattering disk is approximately midway between the pulsar and the earth, we compute transverse velocities for the seven pulsars. These values are generally in good agreement with the proper motion velocities. | NaWang Xin-JiWu 等 | 2001 | Chinese Journal of Astronomy and Astrophysics2001，1，5： | 0 |
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