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| 1 | Noether symmetries of the nonconservative and nonholonomic systems on time scales显示文摘In this paper we give a new method to investigate Noether symmetries and conservation laws of nonconservative and nonholonomic mechanical systems on time scales , which unifies the Noether's theories of the two cases for the continuous and the discrete nonconservative and nonholonomic systems. Firstly, the exchanging relationships between the isochronous variation and the delta derivatives as well as the relationships between the isochronous variation and the total variation on time scales are obtained. Secondly, using the exchanging relationships, the Hamilton's principle is presented for nonconservative systems with delta derivatives and then the Lagrange equations of the systems are obtained. Thirdly, based on the quasi-invariance of Hamiltonian action of the systems under the infinitesimal transformations with respect to the time and generalized coordinates, the Noether's theorem and the conservation laws for nonconservative systems on time scales are given. Fourthly, the d'Alembert-Lagrange principle with delta derivatives is presented, and the Lagrange equations of nonholonomic systems with delta derivatives are obtained. In addition, the Noether's theorems and the conservation laws for nonholonomic systems on time scales are also obtained. Lastly, we present a new version of Noether's theorems for discrete systems. Several examples are given to illustrate the application of our results. | CAI PingPing FU JingLi GUO YongXin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 52 |
| 2 | Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy显示文摘食道的癌症是在世界上的癌症的最普通的类型之一,并且它在中国表明一个不同地理分发模式。在最后十年,与繁体中文药(TCM ) 导致 apoptosis 在关于癌症治疗的基本、临床的研究成为了一个活跃区域。在这评论,我们总结 TCM 在食道的癌症房间由导致 apoptosis 的分子的机制。这些机制通常与指向外来的死亡受体小径,内在的 mitochondrial 小径,和 endoplasmic 蜂窝胃相关然而并非有限(嗯) 压力小径。由使用不同单体和 TCM 的合成药方,调制 Bcl-2/Bax 的比率是可能的,调整 caspase 朊酶和 mitochondrial transmembrane 潜力的表示,增加船边交货和 p53 的表示,下面调整 NF-κ ; B 小径和砍和 survivin 的表示,并且堵住房间周期前进。 | Yu-shuang ZHANG Qiang SHEN JingLI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 28 |
| 3 | Symmetry theories of Hamiltonian systems with fractional derivatives显示文摘The Noether and Lie symmetries as well as the conserved quantities of Hamiltonian system with fractional derivatives are es-tablished. The definitions and criteria for the fractional symmetrical transformations and quasi-symmetrical transformations inthe Noether sense of Hamiltonian system are first discussed. Then, using the invariance of Hamiltonian action under the infini-tesimal transformations with respect to time, generalized coordinates and generalized momentums, the fractional Noethertheorem of the system is obtained. Further, the Lie symmetry and conserved quantity of the system are acquired. Two exam-ples are presented to illustrate the application of the results. | ZHOU Sha FU Hao FU JingLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 25 |
| 4 | Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus显示文摘Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/ reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In this study, fastigial nucleus stimulation was given to rats 24, 48, and 72 hours before cerebral ischemia/reperfusion injury. Results from the electrical stimulation group revealed that rats exhibited a reduction in brain infarct size, a significant increase in the expression of Ku70 in cerebral ischemia/reperfusion regions, and a decreased number of terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)-positive cells. Double immunofluorescence staining revealed no co-localization of Ku70 with TUNEL-positive cells. However, Ku70 partly co-localized with Bax protein in the cytoplasm of rats with cerebral ischemia/reperfusion injury. These findings suggest an involvement of Ku70 with Bax in the cytoplasm of rats exposed to electrical stimulation of the cerebellar fastigial nucleus, and may thus provide an understanding into the anti-apoptotic activity of Ku70 in cerebral ischemia/reperfusion injury. | Jingli Liu Jinpin Li Yi Yang Xiaoling Wang Zhaoxia Zhang Lei Zhang | 2014 | Neural Regeneration Research2014，9，7： | 26 |
| 5 | Chemical characterization of size-resolved aerosols in four seasons and hazy days in the megacity Beijing of China显示文摘Size-resolved aerosol samples were collected by MOUDI in four seasons in 2007 in Beijing. The PM10 and PM1.8mass concentrations were 166.0 ± 120.5 and 91.6 ± 69.7 μg/m^3, respectively,throughout the measurement, with seasonal variation: nearly two times higher in autumn than in summer and spring. Serious fine particle pollution occurred in winter with the PM1.8/PM10 ratio of 0.63, which was higher than other seasons. The size distribution of PM showed obvious seasonal and diurnal variation, with a smaller fine mode peak in spring and in the daytime. OM(organic matter = 1.6 × OC(organic carbon)) and SIA(secondary inorganic aerosol) were major components of fine particles, while OM, SIA and Ca_2+were major components in coarse particles. Moreover, secondary components, mainly SOA(secondary organic aerosol) and SIA,accounted for 46%–96% of each size bin in fine particles, which meant that secondary pollution existed all year. Sulfates and nitrates, primarily in the form of(NH_4)_2SO_4, NH_4NO_3, Ca SO_4, Na_2SO_4 and K_2SO_4, calculated by the model ISORROPIA II, were major components of the solid phase in fine particles. The PM concentration and size distribution were similar in the four seasons on non-haze days, while large differences occurred on haze days, which indicated seasonal variation of PM concentration and size distribution were dominated by haze days. The SIA concentrations and fractions of nearly all size bins were higher on haze days than on non-haze days, which was attributed to heterogeneous aqueous reactions on haze days in the four seasons. | Kang Sun Xingang Liu Jianwei Gu Yunpeng Li Yu Qu Junling An Jingli Wang Yuanhang Zhang Min Hu Fang Zhang | 2015 | Journal of Environmental Sciences2015，27，6： | 19 |
| 6 | Trends of Extreme Precipitation in Eastern China and Their Possible Causes显示文摘Significant increases of heavy precipitation and decreases of light precipitation have been reported over widespread regions of the globe. Global warming and effects of anthropogenic aerosols have both been proposed as possible causes of these changes. We examine data from urban and rural meteorological stations in eastern China(1955–2011) and compare them with Global Precipitation Climatology Project(GPCP) data(1979–2007) and reanalysis data in various latitude zones to study changes in precipitation extremes. Significant decreases in light precipitation and increases in heavy precipitation are found at both rural and urban stations, as well as low latitudes over the ocean, while total precipitation shows little change.Characteristics of these changes and changes in the equatorial zone and other latitudes suggest that global warming rather than aerosol effects is the primary cause of the changes. In eastern China, increases of annual total dry days(28 days) and 10 consecutive dry days(36%) are due to the decrease in light precipitation days, thereby establishing a causal link among global warming, changes in precipitation extremes, and higher meteorological risk of floods and droughts. Further, results derived from the GPCP data and reanalysis data suggest that the causal link exists over widespread regions of the globe. | LIU Run LIU Shaw Chen Ralph J.CICERONE SHIU Chein-Jung LI Jun WANG Jingli ZHANG Yuanhang | 2015 | Advances in Atmospheric Sciences2015，32，8： | 19 |
| 7 | NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Hart nationality显示文摘AIM: An insertion mutation at nucleotide 3020 (3020insC) in the Caspase recruitment domain gene (CARD15), originally reported as NOD2, is strongly associated with Crohn's disease. The C-insertion mutation at nucleotide 3020 (3020inC) in the leucine-rich repeat (LRR) region results in a frameshift in the 10^th LRR followed by a premature stop codon. This truncation mutation is responsible for the inability to activate nuclear factor (NF)-κB in response to bacterial lipopolysaccharide (LPS). The present study aimed to genotype NOD2/CARD15 gene 3020insC frameshift mutation in Chinese patients with inflammatory bowel disease. METHODS: We genotyped an insertion polymorphism affecting the leucine-rich region of the protein product by the allele specific PCR in 74 unrelated patients with ulcerative colitis of Han nationality in Hubei Province of China, 15 patients with Crohn's disease and 172 healthy individuals. RESULTS: No significant differences were found in the genotype and allele frequendes of the C-insertion mutation of NOD2 gene among patients with Crohn's disease and ulcerative colitis and healthy controls. CONCLUSION: NOD2 gene 3020insC frameshift mutation is not a major contributor to the susceptibility to both Crohn's disease and ulcerative colitis in Chinese Han patients. | Qiu-ShaGuo BingXia YiJiang YanQü JingLi | 2004 | World Journal of Gastroenterology2004，10，7： | 16 |
| 8 | Characteristics and Origin of Tight Oil Accumulations in the Upper Triassic Yanchang Formation of the Ordos Basin,North-Central China显示文摘The Upper Triassic oil accumulations in the Ordos Basin is the most successful tight oil play in China,with average porosity values of less than 10% and permeability values below 1.0 mD.This study investigated the geological characteristics and origin of the tight oil accumulations in the Chang 6 member of the Upper Triassic Yanchang Formation in the Shanbei area based on over 50,000 petrological,source-rock analysis,well logging and production data.The tight oil accumulation of the Chang 6 member is distributed continuously in the basin slope and the centre of the basin.The oilwater relationships are complex.Laumontite dissolution pores are the most important storage spaces,constituting 30%-60% of total porosity and showing a strong positive relationship with oil production.The pore-throat diameter is less than 1 μm,and the calculated critical height of the oil column is much larger than the tight sand thickness,suggesting that the buoyancy was probably of limited importance for oil migration.The pressure difference between the source rocks and sandstone reservoirs is inferred to have provided driving force for hydrocarbon migration.Two factors of source-reservoir configuration and laumontite dissolution contributed to the formation of the Chang 6 tight oil accumulations.Intense hydrocarbon generation and continuous sand bodies close to the hydrocarbon kitchen are the foundation for the large-scale oil distribution.Dissolution of feldspar-laumontite during the process of organic matter evolution generated abundant secondary pores and improved the reservoir quality. | WU Songtao ZOU Caineng ZHU Rukai YAO Jingli TAO Shizhen YANG Zhi ZHAI Xiufen CUI Jingwei LIN Senhu | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 13 |
| 9 | Biogenic production of DMSP and its degradation to DMS—their roles in the global sulfur cycle显示文摘Dimethyl sulfide(DMS) is the most abundant form of volatile sulfur in Earth’s oceans, and is mainly produced by the enzymatic clevage of dimethylsulfoniopropionate(DMSP). DMS and DMSP play important roles in driving the global sulfur cycle and may affect climate. DMSP is proposed to serve as an osmolyte, a grazing deterrent, a signaling molecule, an antioxidant, a cryoprotectant and/or as a sink for excess sulfur. It was long believed that only marine eukaryotes such as phytoplankton produce DMSP. However, we recently discovered that marine heterotrophic bacteria can also produce DMSP, making them a potentially important source of DMSP. At present, one prokaryotic and two eukaryotic DMSP synthesis enzymes have been identified.Marine heterotrophic bacteria are likely the major degraders of DMSP, using two known pathways: demethylation and cleavage.Many phytoplankton and some fungi can also cleave DMSP. So far seven different prokaryotic and one eukaryotic DMSP lyases have been identified. This review describes the global distribution pattern of DMSP and DMS, the known genes for biosynthesis and cleavage of DMSP, and the physiological and ecological functions of these important organosulfur molecules, which will improve understanding of the mechanisms of DMSP and DMS production and their roles in the environment. | Xiao-Hua Zhang Ji Liu Jingli Liu Guipeng Yang Chun-Xu Xue Andrew R. J. Curson Jonathan D. Todd | 2019 | Science China(Life Sciences)2019，62，10： | 11 |
| 10 | Evidence of Oil Sources and Migration in Triassic-Jurassic Reservoirs in the South Tianhuan Depression of the Ordos Basin, China Based on Analysis of Biomarkers and Nitrogen-Bearing Compounds显示文摘The Ordos Basin is an important intracontinental sedimentary basin in western China for its abundant Mesozoic crude oil resources. The southern part of the Tianhuan Depression is located in the southwestern marginal area of this Basin, in which the Jurassic and Triassic Chang-3 are the main oil-bearing strata. Currently, no consensus has been reached regarding oil source and oil migration in the area, and an assessment of oil accumulation patterns is thus challenging. In this paper, the oil source, migration direction, charging site and migration pathways are investigated through analysis of pyrrolic nitrogen compounds and hydrocarbon biomarkers. Oil source correlations show that the oils trapped in the Jurassic and Chang-3 reservoirs were derived from the Triassic Chang-7 source rocks. The Jurassic and Chang-3 crude oils both underwent distinct vertical migration from deep to shallow strata, indicating that the oils generated by Chang-7 source rocks may have migrated upward to the shallower Chang-3 and Jurassic strata under abnormally high pressures, to accumulate along the sand bodies of the ancient rivers and the unconformity surface. The charging direction of the Jurassic and Chang-3 crude oils is primarily derived from Mubo, Chenhao, and Shangliyuan, which are located northeast of the southern Tianhuan Depression, with oils moving toward the west, southwest, and south. The results show that an integration of biomarker and nitrogen-bearing compound analyses can provide useful information about oil source, migration, and accumulation. | ZHAO Yande YAO Jingli SUN Bainian Duan Yi DONG Chong DENG Xiuqing LIU Luofu | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 10 |
| 11 | Microstructure and mechanical property of a high-strength Mg-10Gd-6Y-1.5Zn-0.5Zr alloy prepared by multi-pass equal channel angular pressing显示文摘In this work,a high-strength Mg–10Gd–6Y–1.5Zn–0.5Zr(wt.%)alloy was fabricated by successive multi-pass equal channel angular pressing(ECAP).The microstructure and mechanical property of as-cast and ECAP alloys were systematically researched by X-ray diffractometer,scanning electron microscopy,transmission electron microscopy and compression test.The results show that the microstructure of as-cast alloy consists ofα-Mg grains,Mg24Y5 networks,18R blocks,fine 14H lamellas,and fewY-rich particles.After 8 passes ECAP,dynamic recrystallization ofα-Mg is developed and their average grain size decreases to about 1μm.The network Mg_(24)Y_(5) phase at grain boundaries is broken into small particles with average diameter lower than 0.5μm.Moreover,18R blocks are kinked and delaminated,or broken into small particles and blended with Mg24Y5 particles.14H lamellas grow gradually or are dynamically precipitated within certainα-Mg grains.Compression tests indicate that 8p ECAP alloy exhibits excellent mechanical property with compressive strength of 537 MPa and fracture strain of 17.0%.The significant improvement for both strength and ductility of deformed alloy could be ascribed to DRX grains,refined Mg24Y5 particles,18R kinking and dynamical precipitation of 14H. | Huan Liu He Huang Xiaowei Yang Cheng Li Jingli Yan Jinghua Jiang Aibin Ma | 2017 | Journal of Magnesium and Alloys2017，5，2： | 10 |
| 12 | Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis显示文摘OBJECTIVE:To characterize naringenin(NAR) population pharmacokinetics(PPK) in Chinese women with primary osteoporosis.METHODS:Ninety-eight female patients with primary osteoporosis from the Jingshan,Beixinqiao,Jiaodaokou,Chaoyangmen,and Donghuamen communities in Beijing,China,aged 40 to 80 years,received oral Qianggu capsules(250 mg).Blood samples were collected before and at 0.5,1,2,3,4,6,8,10,12,and 24 h after administration.The concentration of NAR in the blood samples was measured using high performance liquid chromatography-tandem mass spectrometry.PPK analyses were performed with nonlinear mixed-effect modeling software(version 7.1.2,PsN3.2.12).The clearance(C1),central distribution volume(V),absorption rate constant(Ka1),peripheral distribution volume(VII),and inter-compartmental clearance(CLII) were set as parameters and estimated by the base model,covariate model,and final model.Kidney-Yang deficiency[Shenyangxu(SYAX)]and liver-kidney-Yin deficiency(Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates,along with age,height,blood urea nitrogen,serum creatinine,alanine transaminase,aspartate transaminase,and hyperlipidemia.Both stepwise forward and backward procedures were accomplished to build models.The final model was evaluated by internal and external validation,visual predictive check,bootstrap,and leverage analysis.RESULTS:A one compartment open model with first order degradation was the best fitted to the concentration-time profiles following oral administration of NAR.The mean of population parameters of the final model,C1,SYAX on C1,V,Ka1,CLII,and VII,were measured to be 37.6 L/h,0.427 L,123 L/h,0.12/h,0.3056,and 1.446,respectively.Inter-individual variability was estimated and SYAX was identified as a significant covariate.CONCLUSION:The population pharmacokinetic model described in this study could effectively characterize the pharmacokinetic profile of NAR following administration of a single dose of oral Qianggu capsules in Chinese women with primary osteoporosis.Among the tested covariates,only SYAX was a significant factor. | Wang Jiannong Jiang Junjie Xie Yanming Wei Xu Li Jianpeng Duan Jingli Xiong Xin | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 9 |
| 13 | Groundwater Flow Simulation and its Application in Groundwater Resource Evaluation in the North China Plain,China显示文摘这研究的目的是为评估北方中国的地下水资源建立 3D 地下水流动建模平凡的。首先,北方中国平原通过 hydrogeological 条件的描述垂直地被划分成三含水土层。地下水模型软件公克被用于当模特儿把模拟的区域划分成 164 排和 148 根线的一个常规网络。这个模型通过适合被验证观察并且模仿的地下水流动在 64 口典型观察井在在观察并且模仿的自记水位计之间的深、浅的层和比较删除。而且,水预算分析也在模拟时期(20022003 ) 期间被执行。确定的地下水流动模型的结果证明平均年度地下水在 1991 ~ 2003 期间北方中国平原再装 256.68 是慭档湩 e ??辸 吗?? | SHAO Jingli LI Ling CUI Yali ZHANG Zhaoji | 2013 | Acta Geologica Sinica(English Edition)2013，87，1： | 9 |
| 14 | The internalization pathway,metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell显示文摘The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways: The SPIONs were distributed to daughter cells during mitosis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage but affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool. | GU JingLi XU HaiFei HAN YeHua DAI Wei HAO Wei WANG Chun Yu GU Ning XU HaiYan CAO JiMin | 2011 | Science China(Life Sciences)2011，54，9： | 8 |
| 15 | 固体氧化物质子传导膜H_2S燃料电池显示文摘A brief overview of the past and present state of art in the field of H2S solid oxide fuel cell is presented.Electrochemical performance of a proton-conducting solid oxide fuel cell having the configuration of H2S,(MoS2+NiS)/Li2SO4-Al2O3/Pt,air was investigated.The experimental results showed that electrolyte materials like Li2SO4-Al2O3, and anode substances such as MoS2+NiS showed good chemical stability under the operating conditions of a fuel cell using H2S as the fuel, and that binary metal sulfides such as MoS2+NiS as an anode catalyst was superior to a single metal sulfide of MoS2 which sublimes above 450 ℃, and better than Pt which could be detached and resulted in the degradation of anode due to the formation of PtS.The proton-conducting and cell performance was improved at elevated temperatures due to the increase of electrochemical reaction rate and the reduction of cell resistance.OCV values around 1.0 V were observed.The maximum current and power density values obtained at 600 ℃ were 20 mA·cm -2 and 4 mW· cm -2, and as high as 200 mA· cm -2 and 55 mW· cm -2 were achieved at 700 ℃, respectively.Three different anode catalysts, Pt, MoS2+NiS and MoS2+NiS+Ag were described.The conductance of cell increased and the cell performance was improved with Ag powder added to anode catalysts.Current density up to 250 mA· cm -2 and power density up to 70 mW· cm -2 were achieved with the anode catalyst MoS2+NiS+Ag compared to those with MoS2+NiS at 700 ℃. | 钟理 陈建军 WEI Guolin LUO Jingli CHUANG Karl | 2004 | 化工学报2004，55，10： | 6 |
| 16 | Study on the Estimation of Groundwater Withdrawals Based on Groundwater Flow Modeling and Its Application in the North China Plain显示文摘The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the calculation of the amount of water withdrawal significantly influences the regional groundwater resource evaluation and management. However, the decentralized groundwater pumping, inefficient management, measurement errors and uncertainties have resulted in considerable errors in the groundwater withdrawal estimation. In this study, to improve the estimation of the groundwater withdrawal, an innovative approach was proposed using an inversion method based on a regional groundwater flow numerical model, and this method was then applied in the North China Plain. The principle of the method was matching the simulated water levels with the observation ones by adjusting the amount of groundwater withdrawal. In addition, uncertainty analysis of hydraulic conductivity and specific yield for the estimation of the groundwater withdrawal was conducted. By using the proposed inversion method, the estimated annual average groundwater withdrawal was approximately 24.92×109 m3 in the North China Plain from 2002 to 2008. The inversion method also significantly improved the simulation results for both hydrograph and the flow field. Results of the uncertainty analysis showed that the hydraulic conductivity was more sensitive to the inversion results than the specific yield. | Jingli Shao Yali Cui Qichen Hao Zhong Han Tangpei Cheng | 2014 | Journal of Earth Science2014，25，6： | 6 |
| 17 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 18 | Parameterization of COSMO-RS model for ionic liquids显示文摘The adjustable parameters in the popular conductor-like screening model for real solvents(COSMO-RS)within the Amsterdam density functional(ADF)framework have been re-optimized to fit for the systems containing ionic liquids(ILs).To get the optimal values of misfit energy constant a^0,hydrogen bond coefficient c_(hb)and effective contact surface area of a segment a_(eff),2283 activity coefficient data points at infinite dilution and 1433 CO_2 solubility data points exhaustively collected from references were used as training set.The average relative deviations(ARDs)of activity coefficients at infinite dilution and CO_2 solubility between experimental data and predicted values are 32.22%and17.61%,respectively,both of which are significantly lower than the original COSMO-RS versions.Predictions for other activity coefficients of solutes in ILs,solubility data of CO_2 in pure ILs and the binary mixtures of ILs at either high or low temperatures,and vapor–liquid equilibrium(VLE)for binary systems involving ILs have also been performed to demonstrate the validity of the parameterization of COSMO-RS model for ILs.The results showed that the predicted results by COSMO-RS model with the new optimized parameters are in much better agreement with experimental data than those by the original versions over a wide temperature and pressure range.The COSMO-RS model for ILs presented in this work improves the prediction accuracy of thermodynamic properties for the systems containing ILs,which is always highly desirable for general chemical engineers. | Jingli Han Chengna Dai Gangqiang Yu Zhigang Lei | 2018 | Green Energy & Environment2018，3，3： | 6 |
| 19 | Enhancement of humoral immune responses to HBsAg by heat shock protein gp96 and its N-terminal fragment in mice显示文摘AIM: Most studies on the immune effect of gp96 were focused on its enhancement of CTLs. It is interesting to know whether gp96 could influence the humoral immune response, and whether the recombinant N-terminal fragment of gp96 could substitute native gp96 to stimulate the immune system.METHODS: gp96 isolated from livers of normal mice and its N-terminal fragment (amino acid 22-355) expressed in E coli were used for immunization of BALb/c mice. Eight groups of mice received one of the following regiments subcutaneously in 100 μL phosphate buffered saline (PBS)at an interval of 3 wk. Group 1: PBS only; group 2:gp96 only; group 3: N-terminal fragment only; group 4: HBsAg only; group 5: HBsAg+gp96; group 6: HBsAg+N-terminalfragment; group 7: HBsAg+incomplete Freud's adjuvant; group 8: HBsAg+N-terminal fragment (95 ℃ heated for 30 min). Serum anti-HBsAg antibody levels were assayed by ELISA. CTL responses in splenocytes were analyzed by ELISPOT after the last vaccination.RESULTS: The average titer of serum anti-HBsAg antibodyin the mice immunized with HBsAg together with gp96 or its N-terminal fragment were much higher than those immunized with HBsAg alone detected by ELISA. The cellular immune response of the mice immunized with HBsAg together with gp96 or its N-terminal fragment was not different with those immunized with HBsAg alone measured by ELISPOT assay.CONCLUSION: gp96 or its N-terminal fragment greatly improved humoral immune response induced by HBsAg, but failed to enhance the CTL response, which demonstrated the potential of using gp96 or its N-terminal fragment as a possible adjuvant to augment humoral immune response against HBV infection. | Hong-TaoLi Jia-BinYan JingLi Ming-HaiZhou Xiao-DongZhu Yu-XiaZhang PoTien | 2005 | World Journal of Gastroenterology2005，11，19： | 6 |
| 20 | Changes of brain gray matter structure in Parkinson's disease patients with dementia显示文摘Voxel-based morphometry is gaining considerable interest for studies examining Parkinson's disease dementia patients.In this study,12 patients with clinically defined Parkinson's disease and dementia and 12 non-demented patients with Parkinson's disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence.Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software.Differences in gray matter volume were represented with statistical parametric mapping.Compared with Parkinson's disease patients without dementia,decreased gray matter volume in Parkinson's disease dementia patients was observed in the bilateral superior temporal gyrus,bilateral posterior cingulate and left cingulate gyrus,right parahippocampal gyrus and hippocampus,right precuneus and right cuneus,left inferior frontal gyrus and left insular lobe.No increased gray matter volume was apparent.These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia. | Jianguo Xia Jinlin Miu Hongbin Ding Xiuping Wang Hua Chen Juan Wang Juan Wu Jingli Zhao Huanxin Huang Weizhong Tian | 2013 | Neural Regeneration Research2013，8，14： | 6 |
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