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| 1 | Mediterranean Berries as Inhibitors of Lipid Oxidation in Porcine Burger Patties Subjected to Cooking and Chilled Storage显示文摘The efficiency of extracts from Arbutus unedo L.(AU),Crataegus monogyna L.(CM),Rosa canina L.(RC),and Rubus ulmifolius Schott.(RU)to inhibit lipid oxidation in raw,cooked and cooked and chilled(2°C/12 d)porcine burger patties,was investigated.The modification of the fatty acid profile during processing treatments(cooking and chilling),the quantitative measurements of thiobarbituric acid reactive substances(TBA-RS),and lipid-derived volatiles,were used as indicators of lipid oxidation.Polyunsaturated fatty acids(PUFA)gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being significantly greater(P<0.05)in control patties than in those with added berry extracts.In accordance,the control patties showed significantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts(P<0.05).Results from the present work show,for the first time,that extracts from A.unedo,C.monogyna,R.canina,and R.ulmifolius are promising antioxidants which could enhance the nutritional,safety and sensory properties of porcine burger patties. | Rui Ganho Mario Estévez Mónica Armenteros David Morcuende | 2013 | Journal of Integrative Agriculture2013，12，11： | 16 |
| 2 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 3 | Solutions for submucosal injection: What to choose and how to do it显示文摘During the past decades, endoscopic resection techniques have gradually improved and gained more importance for the management of premalignant lesions and early cancers. These endoscopic resection techniques can be divided in 3 major groups: snare polipectomy, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD). The use of submucosal injection is essential for the majority of EMR techniques and is an integral part of ESD,whereas during polipectomy it is not crucial in most cases except to prevent bleeding in large polyps and/or those with large stalks as an alternative to mechanical methods. Injection provides a lifting up effect of the lesion separating it from the muscular layer, thereby reducing thermal injury and the risk of perforation and bleeding while also facilitating en-bloc resection by improving technical feasibility. With this work, we aim to review the most common endoscopic resection techniques and the importance of submucosal injection in each one of them. For that, we present some of the most commonly used submucosal injection solutions, taking into account their advantages and disadvantages. We also discuss, based on current recommendations and our own experience, how and when to preform submucosal injection, depending on lesions features and endoscopic resection technique that′s being used, to assure complete resection and to prevent associated adverse events. Finally, we also present and discuss some new proposed submucosal injection solutions,endoscopic resection techniques and devices that may have a major impact on the future of therapeutic endoscopy. | Rui Castro Diogo Libanio Inês Pita Mário Dinis-Ribeiro | 2019 | World Journal of Gastroenterology2019，25，7： | 13 |
| 4 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 5 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 6 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 7 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 8 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 9 | Epicardium-to-fat transition in injured heart显示文摘 | Qiaozhen Liu Xiuzhen Huang Jin-Hee Oh Ruei-Zeng Lin Shengzhong Duan Ying Yu Rui Yang Ju Qiu Juan M Melero-Martin William T Pu Bin Zhou | 2014 | Cell Research2014，24，11： | 2 |
| 10 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 11 | Prevalence and associated metabolic factors of fatty liver disease in the elderly显示文摘 | Zhongli Wang Ming Xu Jianhong Peng Li Jiang Zhengguo Hu Hua Wang Shiqing Zhou Rui Zhou Michael Hultstr?m En Yin Lai | 2013 | Experimental Gerontology2013，，8： | 2 |
| 12 | The 1,4-Naphthoquinone Scaffold in the Design of Cysteine Protease Inhihitors显示文摘 | CLAUDIA V RUI M RITA C | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 13 | The dynamic relation between stock returns and trading volume:domestic and cross-country evidence显示文摘 | Lee Bong-Soo Rui Oliver M | 2002 | Journal of banking and finance2002，26，： | 1 |
| 14 | Public Governance and Corporate Finance: Evidence from Corruption Cases显示文摘 | FAN J P RUI O M ZHAO M | 2008 | Journal of Comparative Economics2008，36，3： | 1 |
| 15 | Carrier aggregation for LTE -advanced: uplink multiple access and transmission en- hancement features显示文摘 | Rui Y Cheng P Li M Q | 2013 | IEEE Wireless Communications2013，20，4： | 1 |
| 16 | The dynamic relation between stock returns, trading volume,and volatility 显示文摘 | CHEN Gong- meng FIRTH M RUI O M | 2001 | The Financial Review2001，，38： | 1 |
| 17 | Relevance feedback:a power tool for interactive content-based image retrieval显示文摘 | RUI Y HUANG T S ORTEGA M | 1998 | IEEE CSVT1998，8，5： | 1 |
| 18 | Effects of acute stress]on blood dotting and yeast killing by phagocytes of rainbow trout显示文摘 | RUIS M A W BAYNE C J | 1997 | Journal of Aquatic Animal Health1997，9，： | 1 |
| 19 | Probable risk factors for postoperative delirium in patients undergoing spinal surgery 显示文摘 | Rui C Yang ZZ Li M | 2008 | Eur SpineJ2008，17，11： | 1 |
| 20 | Zeolite thin films; from computer chips to space stations显示文摘 | Lew C M Cai Rui Yan Yushan | 2009 | Accounts of Chemical Research2009，43，2： | 1 |
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