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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | The value of the world' s ecosystem services and natural capital显示文摘 | Costanza R Ralph d' Arge Rudolf de Groot | 1997 | Nature1997，387，： | 1 |
| 4 | The valve of the world's ecosystem services and natural capital 显示文摘 | Costanza R Rudolf D de Groot R | 1997 | Nature1997，387，： | 1 |
| 5 | Laser-assisted subepithelial keratectomy and photore-refractive keratectomy for the correction of hyperopia results of a 2-year follow-up显示文摘 | Rudolf A Jaroslav R | | 0，，11： | 1 |
| 6 | The value of the world's ecosystem services and natural capital显示文摘 | CONSTANZA R ARGE R d' RUDOLF de GROOT | 1997 | Nature1997，387，： | 1 |
| 7 | The value of the world's ecosystem services and natural capital显示文摘 | Costanza R Arge R Rudolf de Groot | 1997 | Na ture1997，387，： | 1 |
| 8 | The value of the world's ecosystem services and natureal capital显示文摘 | Constanza R Rudolf de Groot el al | 1997 | Nature1997，387，： | 1 |
| 9 | The value of the world' s ecosystem services and natural capital 显示文摘 | Costanza R d' Arge R Rudolf de Groot | 1997 | Nature1997，，387： | 1 |
| 10 | Relationship Learning and Performance Enhancement via Advanced Information Technology:The Case of Taiwanese Dragon Electronics firms显示文摘 | JEAN R J B RUDOLF R S | 2010 | International Marketing Review2010，27，2： | 1 |
| 11 | Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort显示文摘 | Sabrina Schlesinger Krasimira Aleksandrova Tobias Pischon Veronika Fedirko Mazda Jenab Elisabeth Trepo Paolo Boffetta Christina C. Dahm Kim Overvad Anne Tj?nneland Jytte Halkj?r Guy Fagherazzi Marie‐Christine Boutron‐Ruault Franck Carbonnel Rudolf Kaaks A | 2012 | Int J Cancer2012，，3： | 1 |
| 12 | Relationship between microstrueture, eytotoxicity and corrosion properties of a Cu-AI-Ni shape memon'y alloy 显示文摘 | Colic M Rudolf R Stamenkovi6 D | 2010 | Aeta Binmaterialia2010，6，1： | 1 |
| 13 | In vivo monitoring of Ca2+ uptake into mitochondria of mouse skeletal muscle during contraction显示文摘 | Rudolf R Mongillo M Magalhaes P J Pozzan T | 2004 | Cell Biol2004，166，4： | 1 |
| 14 | The value of the world's ecosystem services and natural capital显示文摘 | D'arge R Rudolf DE G | 1997 | Nature1997，387，： | 1 |
| 15 | The value of the world's ecosystem services and natural capital 显示文摘 | Constanza R d' Arge R Rudolf de Groot | 1997 | Nature1997，387，： | 1 |
| 16 | Blood collection from the sublingual vein in mice and hamsters:a suitable alternative to retrobulbar technique that provides large volumes and minimizes tissue damage显示文摘 | Heimann K Kasermann H P Rudolf Pfister R P | 2009 | Lab Anim2009，，： | 1 |
| 17 | Geochemistry of a tropical lake (Lake Leopoldo) on pseudo-karst topography within the Roraima Group,Guayana Shield,Venezuela显示文摘 | Yanes C Alvarez H Rudolf Jaffé R | | 0，，： | 1 |
| 18 | The value of the world's ecosystem services and natural capital显示文摘 | Costanza R Arge R Rudolf de Groot | 1997 | Nature1997，387，： | 1 |
| 19 | The value of the world, secosystem Services and natural capita 显示文摘 | ] Costanza R D Aige R Rudolf D G | 1997 | Nature1997，387，： | 1 |
| 20 | A qualitative in- vestigation into the levers and barriers to weight loss in children: opinions of obese children 显示文摘 | Murtagh J Dixey R Rudolf M | 2006 | Arch Dis Child2006，91，11： | 1 |
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