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| 1 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 3 | Two pathways for base excision repair in mammalian cells显示文摘 | Frosina G Fortini P Rossi O | 1996 | J Biol Chem1996，271，16： | 1 |
| 4 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) priming with successive concomitant low-dose Ara-C for elderly patients with secondary/refractory acute myeloid leukemia or advanced myelodysplastic syndrome显示文摘 | ROSSI H A O'DONNELL J SARCINELLI F | 2002 | Leukemia2002，16，3： | 1 |
| 5 | A Landscape Ap- proach to Biodiversity and Biological Health Plan- ning: The Map of Italian Nature显示文摘 | Zurlini G Rossi O Amadio V | 1999 | Ecosystem Health1999，5，4： | 1 |
| 6 | Chemoradiation instead of surgery to treat mid and low rectal tumors: is it safe? 显示文摘 | Nakagawa WT Rossi BM de O Ferreira F | 2002 | Ann Surg Oncol2002，9，6： | 1 |
| 7 | Early predictors of morbidity and mortality in trauma patients treated in the intensive care unit显示文摘 | BRATTSTRM O GRANATH F ROSSI P | 2010 | Acta Anaesthesiol Scand2010，54，8： | 1 |
| 8 | Cancer-induced cachexia:a guide for the oncologist显示文摘 | Gullett N Rossi P Kucuk O | 2009 | J Soc Integr Oncol2009，7，4： | 1 |
| 9 | Linear MMSE Estimation of Time-frequency Variant Channels for MIMO-OFDM Systems显示文摘 | Rossi P S Muller R R Edfors O | 2011 | Signal Processing2011，91，5： | 1 |
| 10 | Diagenesis, provenance and reservoir quality of Triassic TAGI sandstones from Ourhoud field, Berkine (Ghadames) Basin, Algeria 显示文摘 | Rossi C Kalin O Arribas J | 2002 | Marine and Petroleum Geology2002，19，2： | 1 |
| 11 | Light environment, growth and morphogenesis in a peach tree canopy 显示文摘 | Baraldi R Rossi F Facini O | 1991 | Physiologia Plantarum1991，，： | 1 |
| 12 | Kinetics and mechanistic study of the reaction of cyclic anhydrides with substituted phenols structure-reactivity relationships 显示文摘 | Gabriel O Andres Rite H de Rossi | 2005 | J Org Chem2005，70，： | 1 |
| 13 | Polymor- phisms of innate immunity genes influence disease progres- sion in HIV-l-infected children 显示文摘 | Freguja R Gianesin K Del Bianco P Malacrida S Ram- pon O Zanchetta M Giaquinto C De Rossi A | 2012 | AIDS2012，26，6： | 1 |
| 14 | Increased annual frequency of Hashimoto's thyroiditis between years 1988 and 2007 at a cytological unit of Sicily显示文摘 | Rizzo M Rossi RT Bonaffini O | 2010 | Ann Endocrinol2010，71，6： | 1 |
| 15 | Benign migraine-like syndrome with CSF pleocytosis in children显示文摘 | Vassella F Bajc O | 1985 | Dev Med Child Neurol1985，27，2： | 1 |
| 16 | The transport of L-glutamine into cultured human fibroblasts显示文摘 | Dall AV Rossi PA Bussolati O | 1990 | Biochim Biophys Acta1990，1052，1： | 1 |
| 17 | Treatment of patients with small- cell lung cancer: from meta-analyses to clinical practice 显示文摘 | Rossi A Martelli O Di Maio M | 2013 | Cancer Treat Rev2013，39，： | 1 |
| 18 | Treatment of patients with small cell lung cancer: from meta-analyses to clinical practice显示文摘 | ROSSI A MATELLI O DI MAIO M | 2013 | Cancer Treat Rev2013，39，5： | 1 |
| 19 | Analysis of repair of abasic sites in early onset breast cancer patients 显示文摘 | Rossi O Carrozzino F Cappelli E | 2000 | International Journal of Cancer2000，85，1： | 1 |
| 20 | Carbon nanotube actuators显示文摘 | Baughman R H Cui C X Zakhidov A A Iqbal Z Barisci J N Spinks G M Wallace G G Mazzoldi A De Rossi D Rinzler AG Jaschinski O Roth Siegmar Kertesz M | 1999 | Science1999，284，5418： | 1 |
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