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| 1 | Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein显示文摘Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demon- strated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention. | Nicholas TRAKUL Marsha R. ROSNER | 2005 | Cell Research2005，15，1： | 25 |
| 2 | Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor显示文摘房间有大量的控制维持他们的完整并且阻止随机切换到另外一个一个生物状态。Raf Kinase 禁止的蛋白质(RKIP ) , phosphatidylethanolamine 绑定蛋白质(PEBP ) 的一个成员家庭,表明工作维持“ yin yang ”或生物系统的平衡的串联的调节的人的一个新类是代表性的。RKIP 禁止地图 kinase (Raf-MEK-ERK ) ,表明串联的 G 联合蛋白质的受体(GPCR ) kinase 和 NFkappaB。因为 RKIP 指向依赖于它磷酸化的状态的不同家族 ases, RKIP 也行动集成多重环境刺激开始的串音。RKIP 的损失或弄空导致正常细胞的壅滞和罐头的混乱导致象癌症那样的 chromosomal 畸形和疾病状态。因为 RKIP 和 PEBP 家庭以前被考察了,这分析的目标是提供更改并且加亮一些 RKIP 的唯一的特征在细胞的发信号的过程的规定使它成为一个批评播放器。 | Alexey E Granovsky Marsha Rich Rosner | 2008 | Cell Research2008，18，4： | 9 |
| 3 | Advances in the genetics of Parkinson's disease显示文摘Parkinson 的疾病(PD ) 是影响变老的人口的一个重要比例的神经变性混乱。病原学是未知的,它在变老的背景上由于基因和环境的一个多因素的相互作用是可能的。在最后十年的调查结果比以前欣赏建议到 PD 的家庭形式的遗传的贡献大得多。12 部位现在与被联系高度 penetrant 正染色体的主导或后退的 PD,和原因的变化与与特发病难区分的显型经常描绘的变化搬运人一起在八基因被识别了。迄今为止, PD 药物疗法仅仅是征兆的并且不减缓疾病前进。理解基因变化怎么引起家庭 PD 是可能的澄清一般来说位于 PD 下面的分子的机制并且将为新奇治疗的发展提供一个指南,预防和 palliative,对震颤性麻痹的所有形式适用。这评论在 PD 和他们的可能的临床的含意的基因背景的学习构画出进展。 | Serena ROSNER Nir GILADI Avi ORR-URTREGER | 2008 | Acta Pharmacologica Sinica2008，29，1： | 4 |
| 4 | AMD进展与C反应蛋白、白介素6及其他心血管生物标记间的前瞻性研究 | Seddon J.M George S Rosner B Rifai N 潘佳鸿 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，12： | 3 |
| 5 | The clinical implications of the genetics of renal cell carcinoma显示文摘 | Inger Rosner Gennady Bratslavsky Peter A. Pinto W. Marston Linehan | 2009 | Urologic Oncology: Seminars and Original Investigations2009，，2： | 2 |
| 6 | Monocyte-derived Wnt5a regulates inflammatory ymphangiogenesis显示文摘 | Roberto Sessa Don Yuen Stephanie Wan Michael Rosner Preethi Padmanaban Shaokui Ge April Smith Russell Fletcher Ariane Baudhuin-Kessel Terry P Yamaguchi Richard A Lang LuChen | 2016 | Cell Research2016，26，2： | 2 |
| 7 | Systolic and diastolic blood pressure,pulse pressure,and mean arterial pressure as predictors of cardiovascular disease risk in men显示文摘 | Sesso HD Stampger MJ Rosner B | 2000 | Hypertension2000，36，5： | 1 |
| 8 | Dietary fatty acid intakes and the risk of ovulatory infertility显示文摘 | Chavarro JE Rich-Edwards JW Rosner BA | 2007 | Am J Clin Nutr2007，85，1： | 1 |
| 9 | Smoking and smoking cessation in relation to mortality in women显示文摘 | Kenfield SA Stampfer MJ Rosner BA | 2008 | JAMA2008，299，17： | 1 |
| 10 | Factors in predicting blood pressure change显示文摘 | Sparrow D Garvey AJ Rosner B | 1982 | Circulation1982，65，4： | 1 |
| 11 | Musculoskeletal syndromes associated with malignancy (excluding hypertrophic osteoarthropathy) 显示文摘 | Naschitz JE Rosner I | 2008 | Curt Opin Rheumatol2008，20，1： | 1 |
| 12 | Phase Ⅰ evalution of prolonged - infusion gemcitabine with mitoxantrone for relapsed or refractory acute leukemia 显示文摘 | Rizzieri DA Bass AJ Rosner GL | 2002 | J Clin Oncol2002，20，3： | 1 |
| 13 | Sex hormone levels in premenopausal African-Amenrican Women with upper and lower body fat phenotype显示文摘 | Barrett JB Wouds MN Rosner B | 2001 | Nutr Cancer2001，41，12： | 1 |
| 14 | Differentiation among isolates of prunus necrotic ringspot virus by transcript conformation polymorphism显示文摘 | Rosner A Maslenin L Spiegel S | 1998 | Journal of Virological Methods1998，74，1： | 1 |
| 15 | Functional deficits resulting from laser-induced damage in the rat reti- na显示文摘 | Ben-Shlomo G Belokopytov M Rosner M | 2006 | Lasers Surg Med2006，38，： | 1 |
| 16 | Thermophoretic Effects on Particles in Counterflow Laminar Diffusion Flames显示文摘 | Alessandro Gomez Daniel E. Rosner | 1993 | Combustion Science and Technology (-)1993，，5： | 1 |
| 17 | Ocular problems in the patient with end stage renal disease显示文摘 | Mullaem G Rosner MH | 2012 | Semin Dial2012，4，： | 1 |
| 18 | Cerebral perfusion pressure, intracranial pressure, and head elevation显示文摘 | Rosner M Coley I | 1986 | J Neurosurgery1986，65，： | 1 |
| 19 | Hairpin-based virus resistance depends on the sequence similarity between challenge virus and discrete, highly accumulating siRNA species显示文摘 | Gaba V Rosner A Maslenin L | 2010 | Eur J Plant Pathol2010，，128： | 1 |
| 20 | The ECG diagnosis of acute myocardial infarction in the present of left bundle branch block 显示文摘 | Rosner MH Brady WJ | 1998 | Am J Emerg Med1998，16，7： | 1 |
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