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| 1 | Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C显示文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target. | ángel Hernández-Bartolomé Rosario López-Rodríguez María Jesús Borque Leticia González-Moreno Yolanda Real-Martínez Luisa García-Buey Ricardo Moreno-Otero Paloma Sanz-Cameno | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 2 | Mitochondrial markers for the detection of four duck species and the specific identification of Muscovy duck in meat mixtures using the polymerase chain reaction显示文摘 | Irene Martín Teresa García Violeta Fajardo Inés López-Calleja María Rojas Pablo E. Hernández Isabel González Rosario Martín | 2007 | Meat Science2007，，4： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 5 | Comparative study of the nutritional and bioactive compounds content of four walnut ( Juglans regia L.) cultivars显示文摘 | María Isabel Tapia Juan Ramón Sánchez-Morgado Jesús García-Parra Rosario Ramírez Teresa Hernández David González-Gómez | 2013 | Journal of Food Composition and Analysis2013，，2： | 1 |
| 6 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | ROSARIO A V BULHOES L S PEREIRA E C | 2006 | Journal of Power Sources2006，158，： | 1 |
| 7 | An International analysis ofthe quality of open government data portals显示文摘 | MARTIN A S ROSARIO A H D PéREZL M D C C | 2015 | Social science computer review2015，，6： | 1 |
| 8 | Investigation of Glazing Behavior in a Fire Environment Using a Spectral Discrete Ordinates Method for Radiative HeatTransfer 显示文摘 | Dembele S Rosario R A F Wen J X | 2007 | Numerical Heat Transfer Part B2007，52，： | 1 |
| 9 | 显示文摘 | Michelle R S Caitlin E M Rosario A G et aI | 2012 | Polymer2012，53，4： | 1 |
| 10 | Antihypertensive Effects of Peroxisome Proliferator-Activated Receptor-β Activation in Spontaneously Hypertensive Rats显示文摘 | María José Zarzuelo Rosario Jiménez Pilar Galindo Manuel Sánchez Ana Nieto Miguel Romero Ana María Quintela Rocío López-Sepúlveda Manuel Gómez-Guzmán Elvira Bailón Isabel Rodríguez-Gómez Antonio Zarzuelo Julio Gálvez Juan Tamargo Francisco Pérez-Vizcaíno | 2011 | Hypertension2011，，4： | 1 |
| 11 | Development of a real time PCR assay for detection of allergenic trace amounts of peanut ( Arachis hypogaea ) in processed foods显示文摘 | Inés María López-Calleja Silvia de la Cruz Nicolette Pegels Isabel González Teresa García Rosario Martín | 2013 | Food Control2013，，2： | 1 |
| 12 | Thin flap laser in situ keratomileusis : Analysis of contrast sensitivity, vis- ual, and refractive outcomes 显示文摘 | Rosario C S Calve M A Beltran J | 2005 | J Cataract Refract Surg2005，31，7： | 1 |
| 13 | Primary hepatic leiomyosarcoma in a child with the acquired immunodeficiency syndrome显示文摘 | Ross J S Del Rosario A Bui H X Sonbati H Solis O | 1992 | Hum Pathol1992，23，： | 1 |
| 14 | E-cadherin expression in papillary transitional cell carcinoma of the urinary bladder 显示文摘 | Ross J S del Rosario A D Figgeb H L | 1995 | Hum Pathol1995，26，9： | 1 |
| 15 | Expression of the CD44cell adhesion molecule in urinary bladder transitional cell carcinoma显示文摘 | Ross J S del Rosario A D Bui H X | 1996 | Mod Pathology1996，9，8： | 1 |
| 16 | Probabi- listic QoS and soft contracts for transaction-based Web serv- ices orchestrations显示文摘 | ROSARIO S BENVENISTE A HAAR S | 2008 | IEEE Transactions on Services Com- puting2008，1，4： | 1 |
| 17 | Comparative study on the adhesive properties of different epoxy resins 显示文摘 | PROLONGO S G ROSARIO G D URENA A | 2006 | International Journal of Adhesion and Adhesives2006，26，3： | 1 |
| 18 | Leukocyte-endothellum interaction during the early stages of hypercholesterolemia in the rabbit: role of P-selectln, ICAM-1, and VCAM-1显示文摘 | ROSARIO S JUMES Z A Ⅲ AILAN M L | 1998 | Arterioscler Thromb Vase Biol1998，18，： | 1 |
| 19 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | Rosario A V Bulhoes L O S | 2006 | Journal of Power Sources2006，158，1： | 1 |
| 20 | A measurement method based on Kalman fihering for ultrasonic time-of-flight estimation 显示文摘 | ANGRISANI L BACCIGALUPI A ROSARIO S L M | 2006 | IEEE Transaction on Instrumentation and Measurement2006，55，2： | 1 |
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