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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 3 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | ROSARIO A V BULHOES L S PEREIRA E C | 2006 | Journal of Power Sources2006，158，： | 1 |
| 4 | ^177 Lu-Antibody Conjugates for Single-Cell Kill of B- Lymphoma Cells in Vitro and for Therapy of Micrometastases in Vivo 显示文摘 | Michel R B Andrews P M Rosario A V | 2005 | Nuel Med Biol2005，32，3： | 1 |
| 5 | The role of Pt addition on the photocata- lytic activity of TiOz nanoparticles: The limit between doping and metallization显示文摘 | Rosario A V Pereira E C | 2014 | Appl Catal B2014，144，： | 1 |
| 6 | Characteriza tion of PEO-Al2O3 composite polymer electrolytes显示文摘 | TAMBELLI C C BLOISE A C ROSARIO A V | 2002 | Electrochimica Acta2002，47，11： | 1 |
| 7 | Capabilities and Limitations of Dispersive Liquid-liquid Microextraction with Solidification of Floating Organic Drop for the Extraction of Organic Pollutants from Water Samples 显示文摘 | LUZ E V A TANIA R P ROSARIO C It et d | 2013 | Analytica Chimica Acta2013，805，24： | 1 |
| 8 | Poly(3-methylthio-phene) / MnO2 composite electrodes as electrochemical capacitors显示文摘 | RIOS E C ROSARIO A V MELLO R M | 2007 | J Power Sources2007，163，2： | 1 |
| 9 | Co- downregulation of PTEN, KAI - 1, and nm23 - H1 tumor/metastasis suppressor proteins in non-small cell lung cancer 显示文摘 | Goncharuk V N Del- Rosario A Kren L | 2004 | Annals of Diagnotics Pathology2004，8，1： | 1 |
| 10 | Preliminary evidence of sustained expression of angiopoietin‐2 during monocyte differentiation in chronic hepatitis C显示文摘 | Yolanda Rodríguez‐Mu?oz Samuel Martín‐Vílchez Rosario López‐Rodríguez ángel Hernández‐Bartolomé Luisa García‐Buey María J. Borque Ricardo Moreno‐Otero Paloma Sanz‐Cameno | 2013 | Liver Int2013，，6： | 1 |
| 11 | Characterization of mirostructure fluctuations in Waspaloy exposed to 760 ℃ for times up to 2500 h 显示文摘 | Kelekanjeri V Siva Kumar G Gerhardt Rosario A | 2006 | Electrochimica Acta2006，51，： | 1 |
| 12 | Co - downregulation of PTEN, KAI - 1, and nm23 - HI tumor/metasta- sis suppressor proteins in non - small cell lung cancer 显示文摘 | GONCHARUK V N DEL ROSARIO A KREN L | 2004 | Ann Diagn Pathol2004，8，1： | 1 |
| 13 | Characterisation of PEO-Al2O3 composite polymer electrolytes显示文摘 | Tambelli C C Bloise A C Rosario A V | 2002 | Electrochim Acta2002，47，： | 1 |
| 14 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | Rosario A V Bulhoes L O S | 2006 | Journal of Power Sources2006，158，1： | 1 |
| 15 | Characterisation of PEO-Al2O3 composite polymer electrolytes显示文摘 | Tambelli C C Bloise A C Rosario A V | 2002 | Electrochim Acta2002，47，： | 1 |
| 16 | Poly (3-methylth- iophene)/MnO2 composite electrodes as electrochemical capaci- tors显示文摘 | RIOS E C ROSARIO A V MELLO R M | 2007 | J Power Sources2007，163，2： | 1 |
| 17 | Spectrum of Calcific Aortic Valve Disease: Pathogenesis, Disease Progression, and treatment Strategies显示文摘 | Rosario V Freeman Catherine M a al | 2005 | Circulation2005，111，： | 1 |
| 18 | A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity显示文摘 | Beserra B T Fernandes R do Rosario V A | 2014 | Clin Nutr2014，10，1： | 1 |
| 19 | Characterization of PEO-Al2O3composite polymer electrolytes 显示文摘 | Tambelli C C Bloise A C Rosario A V | 2002 | Electrochim Acta2002，47，： | 1 |
| 20 | Charac- terization of Mirostructure Fluctuations in Waspaloy Exposed to 760℃ for Times up to 2500h 显示文摘 | Kelekanjeri V Siva Kumar G Gerhardt Rosario A | 2006 | Electrochimica Acta2006，，51： | 1 |
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