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| 1 | Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C显示文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target. | ángel Hernández-Bartolomé Rosario López-Rodríguez María Jesús Borque Leticia González-Moreno Yolanda Real-Martínez Luisa García-Buey Ricardo Moreno-Otero Paloma Sanz-Cameno | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 2 | Mitochondrial markers for the detection of four duck species and the specific identification of Muscovy duck in meat mixtures using the polymerase chain reaction显示文摘 | Irene Martín Teresa García Violeta Fajardo Inés López-Calleja María Rojas Pablo E. Hernández Isabel González Rosario Martín | 2007 | Meat Science2007，，4： | 2 |
| 3 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Characterisation by SPME–GC–MS of the volatile profile of a Spanish soft cheese P.D.O. Torta del Casar during ripening显示文摘 | Francisco José Delgado José González-Crespo Ramón Cava Jesús García-Parra Rosario Ramírez | 2009 | Food Chemistry2009，，1： | 2 |
| 6 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 7 | Uhrasonographic differentiation between metastatic and benign lymphnodes in patients with papillary thyroid carcinoma显示文摘 | Rosario PW de Faria S B icalho L | 2005 | J Ultrasound Med2005，24，10： | 1 |
| 8 | Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma显示文摘 | Rosario PW de Faria S Bicalho L | 2005 | J Ultrasound Med2005，24，10： | 1 |
| 9 | Comparative study of the nutritional and bioactive compounds content of four walnut ( Juglans regia L.) cultivars显示文摘 | María Isabel Tapia Juan Ramón Sánchez-Morgado Jesús García-Parra Rosario Ramírez Teresa Hernández David González-Gómez | 2013 | Journal of Food Composition and Analysis2013，，2： | 1 |
| 10 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | ROSARIO A V BULHOES L S PEREIRA E C | 2006 | Journal of Power Sources2006，158，： | 1 |
| 11 | Ultrasonographic dif- ferentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma 显示文摘 | Rosario PW de Faria S Bicalho L | 2005 | Ultrasound Med2005，24，10： | 1 |
| 12 | Antitumor effect of green tea polyphenolepigallocatechin-3-gallate in ovarian carcinoma cells:evidence for the endothelin-1 as a potential target显示文摘 | Spinella F Rosario L Decandia S | 2006 | Exp Biol Med2006，231，6： | 1 |
| 13 | Fullerenes as a new class of radioprotectors 显示文摘 | Lin H S Lin T S Lai R S D'Rosario T Luh T Y | 2001 | Int J Radiat Biol2001，77，： | 1 |
| 14 | An International analysis ofthe quality of open government data portals显示文摘 | MARTIN A S ROSARIO A H D PéREZL M D C C | 2015 | Social science computer review2015，，6： | 1 |
| 15 | Ultrasonographic differ- entiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma显示文摘 | Rosario PW de Faria S Bicalho L | 2005 | J Ultrasound Med2005，24，10： | 1 |
| 16 | Surface modification of carbon black by oxidation and its influence on the activity of immobilized catalase and iron-phthalocyanines 显示文摘 | Rosario C S Rudy F P Patricia E N | 1996 | Journal of Molecular Catalysis A : Chemical1996，110，2： | 1 |
| 17 | Management of the schatzker VI fractures with lateral locked screw plating显示文摘 | Rosario S Fabrizio P | 2012 | Musculoskelet Surg2012，96，： | 1 |
| 18 | Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma 显示文摘 | ROSARIO PW DE FARIA S BICALHO L | 2005 | Ultrasound Med2005，24，10： | 1 |
| 19 | Investigation of Glazing Behavior in a Fire Environment Using a Spectral Discrete Ordinates Method for Radiative HeatTransfer 显示文摘 | Dembele S Rosario R A F Wen J X | 2007 | Numerical Heat Transfer Part B2007，52，： | 1 |
| 20 | Lysophosphatidylcholine Promotes P-Selectin Expression in Platelets and Endothelial Cell 显示文摘 | Toyoaki M Rosario S Allan ML | | Circ Res0，，： | 1 |
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