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| 1 | Diabetes and cancer:Looking at the multiligand/RAGE axis显示文摘The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years.Although the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic inflammation.In this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth.We high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies. | Armando Rojas Ileana González Erik Morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa | 2011 | World Journal of Diabetes2011，2，7： | 11 |
| 2 | Plant protection and growth stimulation by microorganisms: biotechnological applications of Bacilli in agriculture显示文摘 | Alejandro Pérez-García Diego Romero Antonio de Vicente | 2010 | Current Opinion in Biotechnology2010，，2： | 2 |
| 3 | Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C显示文摘AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration (< 400 000 vs ≥ 400 000), genotype (1/4 vs 3/4), cirrhotic status and ribavirin dose (800/1000/1200 mg/d).RESULTS: A total of 1014 patients were included in the study. Mean age of the patients was 44.3 ± 9.8 years, 70% were male, and 97% were Caucasian. The main sources of HCV infection were intravenous drug abuse (25%) and blood transfusion (23%). Seventyeight percent were infected with HCV genotype 1/4 (68% had genotype 1) and 22% with genotypes 2/3. The HCV-RNA level was > 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%). The planned treatment duration was 48 wk for 92% of patients with genotype 2/3 and 24 wk for 97% of those with genotype 1/4 (P < 0.001). Seven percent of patients experienced at least one reduction in ribavirin or peginterferon α-2a dose, respectively. Only 2% of patients required a dose reduction of both drugs. Treatment was continued until week 12 in 99% of patients. Treatment compliance was ≥ 80% in 98% of patients. EVR was achieved in 87% of cases (96% vs 83% of patients with genotype 2/3 and 1/4, respectively; P < 0.001). The bivariate analysis showed that patients who failed to achieve EVR were older (P < 0.005), had higher ALT (P < 0.05), AST (P < 0.05), GGT (P < 0.001) and ferritin levels (P < 0.001), a diagnosis of cirrhosis (P < 0.001), and a higher baseline viral load (P < 0.05) than patients reaching an EVR. Age < 40 years [odds ratios (OR): 0.543, 95%CI: 0.373-0.790, P < 0.01], GGT < 85 IU/mL (OR: 3.301, 95%CI: 0.192-0.471, P < 0.001), low ferritin levels (OR: 0.999, 95%CI: 0.998-0.999, P < 0.01) and genotype other than 1/4 (OR: 4.716, 95%CI: 2.010-11.063, P < 0.001) were identified as independent predictors for EVR in the multivariate analysis. CONCLUSION: CHC patients treated with peginterferon-α-2a/ribavirin in clinical practice show high EVR. Older age, genotype 1/4, and high GGT were associated with lack of EVR. | Javier García-Samaniego Miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 4 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 5 | Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma: Recurrence Pathway and Prognostic Factors显示文摘 | B. Pérez-Saborido S. Jiménez de los Galanes J.C. Menéu-Díaz C. Jiménez Romero A. Moreno Elola-Olaso Y. Fundora Suárez V. Barra Valencia E. Moreno-González | 2007 | Transplantation Proceedings2007，，7： | 2 |
| 6 | Protection of goats against peste des petits ruminants with recombinant capripoxviruses expressing the fusion and haemagglutinin protein genes of rinderpest virus显示文摘 | Romero T Barrett R P Kitching C | 1995 | Vaccine1995，13，1： | 1 |
| 7 | High volume hemofiltration in septic shock显示文摘 | Romero CM Downey P Hernandez G | 2010 | Med Intensiva2010，34，5： | 1 |
| 8 | Evidence of in vivo differential bioavaelability of the active form of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra amniotic infestion显示文摘 | Maynon E Romero R Pacora P | 2000 | Am J Obstet Gynecol2000，183，： | 1 |
| 9 | Construction of response surface based on progressive-lattice-sampling experimental designs with application to uncertainty propagation显示文摘 | Romero V J Swiler L P Giunta A A | 2004 | Structure Safety2004，26，2： | 1 |
| 10 | Human neutrophil eol- lagenase (matrix metalloproteinase 8 )in parturition, premature rupture of the membranes , and intrauterine infection显示文摘 | Maymon E Romero R Pacora P | 2000 | Am J Obstet Gynecol2000，183，1： | 1 |
| 11 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 12 | Quantification of chlorpheniraminemaleate enantiomers by ultraviolet spectroscopy and chemometricmethods 显示文摘 | VALDERRAMA P ROMERO A L IMAMURA P M | 2010 | Analytical and Bioanalytical Chemistry2010，397，1： | 1 |
| 13 | Determination of organic acids in grape musts, wines and vinegars by high performance liquid-chromatography显示文摘 | ROMERO E G MUNOZ G S ALVAREZ P J M | 1993 | Journal of Chromatography A1993，655，1： | 1 |
| 14 | Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection显示文摘 | Romero R Pacora P | 2000 | AmJ Obstet Gynecol2000，183，1： | 1 |
| 15 | How to become an under11 rescue:Apractical method to teach first aid to primary schoolchildren显示文摘 | Lubrano R Romero S Scoppi P | 2005 | Resuscitation2005，64，3： | 1 |
| 16 | Tumour immunity : effector response to turnout and role of the microen- vironment 显示文摘 | MANTOVANI A ROMERO P PALUCKA A K | 2008 | Lancet2008，371，9614： | 1 |
| 17 | Factors affectingmaturation of avocado somatic embryos 显示文摘 | Quesada R P Romero C S Munoz A B | 2004 | Sci Hortic2004，102，： | 1 |
| 18 | Fuzzy optimized self-organizing maps and their application to document clustering显示文摘 | ROMERO F P PERALTA A SOTO A | 2010 | Soft Computing-A Fusion of Foundations Methodologies and Applications2010，14，8： | 1 |
| 19 | Fully three-dimensional analysis of high-speed train-track-soil-structure dynamic interaction显示文摘 | Galvin P Romero A Domlnguez J | 2010 | Journal of Sound and Vibration2010，329，24： | 1 |
| 20 | Extreme re- verse remodeling in a patient with dilated cardiomyopathy 显示文摘 | Vidic A Mccann P Ramirez Romero JM | 2014 | Circ Heart Fail2014，7，6： | 1 |
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