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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Temperature conversion (mesophilic to thermophilic) of municipal sludge digestion 显示文摘 | De la Rubia M A Romero L I Sales D | 2005 | Aiche Journal2005，51，9： | 1 |
| 3 | Grid cell distortion and modflow' s integrated finit-difference numerical solution 显示文摘 | Romero D M Silver S E | 2006 | Groundwater2006，44，6： | 1 |
| 4 | Development of a new glass-ceramic by means of controlled vitrification and crystallisation of inorganic wastes from urban incineration 显示文摘 | Romero M Rawlings R D Rincon J M | 1999 | J Eur Ceram Soc1999，19，： | 1 |
| 5 | Metacaspase activity of arabidopsis thaliana is regulated by s -nitrosylation of a critical cysteine residue显示文摘 | BELENGHI B ROMERO PUERTAS M C VERCAMMEN D | 2007 | Biol Chem2007，282，2： | 1 |
| 6 | Early meta-bolic programming of puberty onset:impact of changes inpostnatal feeding and rearing conditions on the timing ofpuberty and development of the hypothalamic kisspeptinsystem显示文摘 | Castellano JM Bentsen AH Sánchez-Garrido MA Ruiz-Pino F Romero M Garcia-Galiano D | 2011 | Endocrinology2011，152，9： | 1 |
| 7 | Depo- larization changes during acute myocardial ischemia by e- valuation of QRS slopes: standard lead and vectorial ap-proach显示文摘 | ROMERO D RINGBORN M LAGUNA P | 2011 | Biomedical Engineering IEEE Transactions on2011，58，1： | 1 |
| 8 | Physical map- ping of ribosomal DNA on several species of the subgenus Rosa 显示文摘 | Fernandez -Romero M D Tortes A M Mill6n T | 2001 | Theoretical and Applied Genetics2001，103，6： | 1 |
| 9 | Muhiwalled Carbon Nanotubes for Liquid-phase OxidationFunctionalization, Characterization, and Catalytic Activity显示文摘 | Ovejero G Sotelo J L Romero M D | 2006 | Industrial & Engineering Chemistry Research2006，45，7： | 1 |
| 10 | Effects of doping in polymer light-emitting diodes显示文摘 | ROMERO D B SCHAER M ZUPPIRELI L | 1995 | Appl Phys Lett1995，67，12： | 1 |
| 11 | Immobilized of β- glucosidase on carbon nanotube显示文摘 | Gomez J M Romero M D Fernandz T M | 2005 | Catalysis Letters2005，101，34： | 1 |
| 12 | Optimization and validation method for organic acid determination in wines by high performance liquid cromatography显示文摘 | ROMERO R GflZQUEZ D BAGUR M G S/kNCHEZ-VINAS M | 2010 | Quim2010，33，5： | 1 |
| 13 | Clinical and molecular epidemiology of extended-spectrum beta-laetamase-producing Escherichia coli as a cause of nosoeomial infection or colonization: implications for control 显示文摘 | Rodriguez-Bano J Navarro M D Romero L | 2006 | Clin Infect Dis2006，42，1： | 1 |
| 14 | New host of Heterodera avenae 显示文摘 | Valdeolivas A Romero M D | 1983 | Nematologia Mediterranea1983，11，： | 1 |
| 15 | Cellulase production by Neurospora crassa on wheat straw 显示文摘 | Romero M D Aguado J Gonzalez L | 1999 | Enzyme Microb Technol1999，25，： | 1 |
| 16 | Cellular Response of Pea Plants to Cadmium Toxicity:Cross-talk between Reactive Oxygen Species,Nitric Oxide and Calcium显示文摘 | RODRIGUEZ M ROMERO M C PAZMINO D M | 2009 | Plant Physiol2009，150，： | 1 |
| 17 | Visual object-action recognition:inferring object affordances from human demonstration 显示文摘 | Kjellstr?m H Romero J Kragi D | 2011 | Computer Vision and Image Understanding2011，115，1： | 1 |
| 18 | The future is now: Model‐based clinical trial design for Alzheimer’s disease显示文摘 | K Romero K Ito JA Rogers D Polhamus R Qiu D Stephenson R Mohs R Lalonde V Sinha Y Wang D Brown M Isaac S Vamvakas R Hemmings L Pani LJ Bain B Corrigan | 2015 | Clin. Pharmacol. Ther2015，，3： | 1 |
| 19 | Solubility and Flory Huggins Parameters of SBES,Poly (styrene b-butene/ethylene-b-styrene) Triblock Copolymer,Determined by Intrinsic Viscosity显示文摘 | Ovejero G Perez P Romero M D | | 0，，04： | 1 |
| 20 | Acidity and catalytic activity of AlPO4-B2O3 and Al2O3-B2O3 (5-30% B2O3) systems prepared by impregnation显示文摘 | BAUTISTA F M CAMPELO J M GARCIA A LUNA D MARINAS J M MORENO M C ROMERO A A | 1998 | Appl Catal A: Gen1998，170，1： | 1 |
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