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| 1 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 2 | Clinical applications of advanced magnetic resonance imaging techniques for arthritis evaluation显示文摘Magnetic resonance imaging(MRI) has allowed a comprehensive evaluation of articular disease, increasing the detection of early cartilage involvement, bone erosions, and edema in soft tissue and bone marrow compared to other imaging techniques. In the era of functional imaging, new advanced MRI sequences are being successfully applied for articular evaluation in cases of inflammatory, infectious, and degenerative arthropathies. Diffusion weighted imaging, new fat suppression techniques such as DIXON, dynamic contrast enhanced-MRI, and specific T2 mapping cartilage sequences allow a better understanding of the physiopathological processes that underlie these different arthropathies. They provide valuable quantitative information that aids in their differentiation and can be used as potential biomarkers of articular disease course and treatment response. | Teodoro Martín Noguerol Antonio Luna Marta Gómez Cabrera Alexie D Riofrio | 2017 | World Journal of Orthopedics2017，8，9： | 2 |
| 3 | On a Shallow Water Model for the Simulation of Turbidity Currents显示文摘We present a model for hyperpycnal plumes or turbidity currents that takes into account the interaction between the turbidity current and the bottom,considering deposition and erosion effects as well as solid transport of particles at the bed load due to the current.Water entrainment from the ambient water in which the turbidity current plunges is also considered.Motion of ambient water is neglected and the rigid lid assumption is considered.The model is obtained as a depth-average system of equations under the shallow water hypothesis describing the balance of fluid mass,sediment mass and mean flow.The character of the system is analyzed and numerical simulations are carried out using finite volume schemes and path-conservative Roe schemes. | T.Morales de Luna M.J.Castro Dıaz C.Pares Madronal E.D.Fernandez Nieto | 2009 | Communications in Computational Physics2009，6，9： | 2 |
| 4 | Routing mechanisms for mobile ad hoe networks based on the energy drain rate显示文摘 | Kim D Garcia - Luna - Aceves J Obraezka K | 2003 | IEEE Transactions on Mobile Computing2003，2，2： | 1 |
| 5 | Resolution of ventilator-associated pneumonia:prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome显示文摘 | Luna CM Bianzaco D Niederman MS | 2003 | Crit Care Med2003，31，： | 1 |
| 6 | Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome显示文摘 | Luna CM Blanzaco D Niederman MS | 2003 | Crit Care Med2003，31，： | 1 |
| 7 | Pre- diction of haematoma growth and outcome in patients with in- tracerebral haemorrhage using the CT-angiography spot sign (PREDICT) a prospective observational study显示文摘 | Demchuk A M Dowlatshahi D Rodriguez Luna D | 2012 | Lancet Neu- rol2012，11，4： | 1 |
| 8 | Simplified modeling of a DFIG for transient studies in wind power applica- tions显示文摘 | LUNA A LIMA F K RODRIGUEZ D SANTOS P | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 9 | Resolution of ventilatorassociated pneumonia:prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome显示文摘 | Luna CM Blanzaco D Niederman MS | 2003 | Crit Care Med2003，31，3： | 1 |
| 10 | Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta analysis显示文摘 | Mitchell MF Schottenfeld D Luna GT | 1998 | Obstet Gynecol1998，91，4： | 1 |
| 11 | Resolution of ventilator associated pneumonia:prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome显示文摘 | Luna CM Blanzaco D Niederman MS | 2003 | Crit Care Med2003，，： | 1 |
| 12 | Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53显示文摘 | MONTES DE OCA LUNA R WAGNER D S LOZANO G | 1995 | Nature1995，378，： | 1 |
| 13 | Concen-trated flow erosion rates as affected by rock fragment cover and initialsoil moisture content显示文摘 | Poesen J Luna E D Franca A Nachtergaele J | 1999 | Catena1999，36，： | 1 |
| 14 | Characterization ofcytosolic glutathione S-transferases in striped bass(Moronesaxitilis)显示文摘 | Chang S Donham R T Luna A D | 2008 | Ecotoxicol Environ Safty2008，69，1： | 1 |
| 15 | Novel sample preparation method for safe and rapid detection of Bacillus anthracis spores in environmental powders and nasal swabs显示文摘 | Luna V A King D Davis C | 2003 | Clin Microbiol2003，，41： | 1 |
| 16 | Uprooted but stable: Chilean parties and the concept of party system institutionalization 显示文摘 | Luna J P Altman D | 2011 | Latin American Politics and Society2011，53，2： | 1 |
| 17 | Catalytic performance of Al-MCM -41 materials in the N-alkylation of aniline显示文摘 | Luque P CampeloJ M Luna D | 2007 | J Mol Catal A:Chem2007，269，2： | 1 |
| 18 | Greater oeeipital nerve blockade in cervicogenic,headache显示文摘 | Vincent MB Luna RA Scandiuzzi D | 1998 | Arq Neuropsiquiatr1998，56，4： | 1 |
| 19 | MOCell:a Cellular Ge- netic Algorithm for multiobjective optimization显示文摘 | Antonio J N Juan J D Luna F | 2009 | International Journal of Intelligent Systems2009，24，7： | 1 |
| 20 | Resolution of ventilator-associated pneumonia: Prospective evalua- tion of the clinical pulmonary infection score as an early clinical predictor of outeome显示文摘 | Luna G M Blanzaco D Niederman M S | 2003 | Crit Care Med2003，31，3： | 1 |
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