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| 1 | Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer显示文摘Epithelial ovarian cancer(OC) is a common gynecologic malignancy in women. The standard treatment for OC is maximal cytoreductive surgical debulking followed by platinum-based chemotherapy. Despite the high response rate to primary therapy, approximately 85% of patients will develop recurrent ovarian cancer(ROC). This review identifies the clinical use of trabectedin in the treatment algorithm for ROC, with specific emphasis on platinum-sensitive ROC, for which trabectedin in combination with pegylated liposomal doxorubicin has been approved as a treatment protocol. The main mechanisms of action of trabectedin at the cellular level and in the tumor microenvironment is also discussed as bases for identifying biomarkers for selecting patients who may largely benefit from trabectedin-based therapies. | José Antonio López-Guerrero Ignacio Romero Andrés Poveda | 2015 | Chinese Journal of Cancer2015，34，1： | 5 |
| 2 | Small bowel bacterial overgrowth in patients with alcoholic cirrhosis显示文摘 | Dr. F. Casafont Morencos MD G. Heras Casta?o MD L. Martín Ramos MD Maria J. López Arias MD F. Ledesma MD F. Pons Romero MD | 1996 | Digestive Diseases and Sciences1996，，3： | 2 |
| 3 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 4 | How do glucocorticoids influence stress responses? Integrating permissive,suppressive,stimulatory,and preparative actions显示文摘 | SAPOLSKY R M ROMERO L M MUNCK A U | 2000 | Endocr Rev2000，21，1： | 1 |
| 5 | The role of RhoA/Rho kinase pathway in endothelial dysfunction显示文摘 | Yao L Romero MJ Toque HA | 2010 | J Card-iovasc Dis Res2010，1，4： | 1 |
| 6 | Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants :pleiotropic phenotypes include drought tolerance 显示文摘 | CARLOS ROMERO JOSE M BELLES JOSE L | 1997 | Planta1997，201，： | 1 |
| 7 | Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘 | Lithgow A M Romero L Sanchez I C | 1986 | J Chem Res Synop1986，，5： | 1 |
| 8 | First detection of canine parvovirus type 2c in South America 显示文摘 | Perez R Francia L Romero V | 2007 | Vet Microbiol2007，124，： | 1 |
| 9 | Main?tenance treatment of preterm labor with the oxytocin an?tagonist atosiban显示文摘 | Valenzuela GJ Sanchez-Ramos L Romero R | 2000 | Am J Obstetrics and Gynecology2000，182，5： | 1 |
| 10 | Construction of response surface based on progressive-lattice-sampling experimental designs with application to uncertainty propagation显示文摘 | Romero V J Swiler L P Giunta A A | 2004 | Structure Safety2004，26，2： | 1 |
| 11 | Quantification of chlorpheniraminemaleate enantiomers by ultraviolet spectroscopy and chemometricmethods 显示文摘 | VALDERRAMA P ROMERO A L IMAMURA P M | 2010 | Analytical and Bioanalytical Chemistry2010，397，1： | 1 |
| 12 | MHC classⅠmolecules act as tumor suppressor genes regulating the cell cycle gene expression,invasion and intrinsic tumorigenicity of melanoma cells显示文摘 | Garrido C Paco L Romero I | 2012 | Carcinogenesis2012，33，3： | 1 |
| 13 | Robust two-dimensional weighted and unweighted phase unwrapping that uses fast transforms and iterative methods显示文摘 | Ghiglia D C Romero L A | 1994 | J Opt Soc Am1994，11，1： | 1 |
| 14 | Temperature conversion (mesophilic to thermophilic) of municipal sludge digestion 显示文摘 | De la Rubia M A Romero L I Sales D | 2005 | Aiche Journal2005，51，9： | 1 |
| 15 | How do glucocorticoids influence stress responses Integrating permissive,suppressive,stimulatory,and preparative actions显示文摘 | Sapolsky R M Romero L M Munck A U | 2000 | Endocr Rev2000，21，1： | 1 |
| 16 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 17 | A parallel procedure for nonlinear analysis of reinforced concrete three-dimensional frames显示文摘 | Romero M L Miguel P F Cano J J | 2002 | Computers and Structures2002，80，14： | 1 |
| 18 | Evidence for a positive regulatory role of strawberry (Fragaria x ananassa ) F WRKY1 and Arabidopsis AtWRKY75 proteins in resistance 显示文摘 | Vladimir-Shulaev S Maldonado A M Amil-Ruiz F Santos B Romero F Pliego-Alfaro F Munoz-Blanco J Caballero J L | 2009 | Journal of Experimental Botany2009，60，11： | 1 |
| 19 | Long-term study of the frequency of Escherichia coli and Klebsiella pneumoniae isolates producing extended-spectrum β-lactamases 显示文摘 | Romero L Lopez L Rodriguez-Bano J | 2005 | Clin Microbiol and Infect2005，11，8： | 1 |
| 20 | pH- Dependent Gating in the Streptomyces lividans K^+ Channel显示文摘 | CUELLO L ROMERO J CORTES D | 1998 | Biochemistry1998，37，： | 1 |
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