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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 3 | Textural and structural modifications of saponite from Cerro del Aguila by acid treatment 显示文摘 | BARRIOS M S BUEY C S ROMERO E G | 2001 | Clay Miner2001，36，： | 2 |
| 4 | Postoperative blood salvage and reinfusion in spinal surgery:blood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Olalla E | 2000 | Eu Spine J2000，9，6： | 1 |
| 5 | Evidence of in vivo differential bioavaelability of the active form of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra amniotic infestion显示文摘 | Maynon E Romero R Pacora P | 2000 | Am J Obstet Gynecol2000，183，： | 1 |
| 6 | Floricaula:a homeotic gene required for flower development in Antirrhinum majus显示文摘 | Coen E S Romero J M Doyle S | 1990 | Cell1990，63，： | 1 |
| 7 | An insight into the water retention properties of compacted clayey soils显示文摘 | ROMERO E DELLA VECCHIA G JOMMI C | 2011 | Geotechnique2011，61，4： | 1 |
| 8 | Polymorphiam in repeated 16S rRNA genes is a common property of type strains and environmental isolates of the genus V/br/o显示文摘 | Moreno C Romero J Romilio T E | 2002 | Microbiology2002，148，： | 1 |
| 9 | Acid-activated etal from Peanut Shells:Synthesis,Eharacterization and uptake of organic compounds from aqueous solutions 显示文摘 | Luis C Romero Antonio Bonomo Elio E Gonzo | 2003 | Adsorption Science & Tech- nology2003，21，7： | 1 |
| 10 | Retinol-binding protein 4:a novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus显示文摘 | Mazaki-Tovi S Romero R Vaisbuch E | | 0，，02： | 1 |
| 11 | Comparative study of the spectroscopic properties of Yb3+/Er3+ codoped tellurite glasses modified with R2O(R = Li,Na and K)显示文摘 | DESIRENA H De la ROSA E ROMERO V H | | 0，，02： | 1 |
| 12 | The Effects Of Physical Attractiveness On Job - related Outcomes: A Meta - analysis of Experimental Studies 显示文摘 | Megumi H Stone - Romero E F Coats G | 2003 | Personnel Psychology2003，56，2： | 1 |
| 13 | Human neutrophil eol- lagenase (matrix metalloproteinase 8 )in parturition, premature rupture of the membranes , and intrauterine infection显示文摘 | Maymon E Romero R Pacora P | 2000 | Am J Obstet Gynecol2000，183，1： | 1 |
| 14 | Determination of organic acids in grape musts, wines and vinegars by high performance liquid-chromatography显示文摘 | ROMERO E G MUNOZ G S ALVAREZ P J M | 1993 | Journal of Chromatography A1993，655，1： | 1 |
| 15 | Resveratrol regulates cellular PKC α and δto inhibit growth and induce apoptosis in gastric cancer cells 显示文摘 | Atten M J Godoy - Romero E Attar BM | 2005 | Investigational New Drugs2005，23，： | 1 |
| 16 | Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection显示文摘 | Romero R Pacora P | 2000 | AmJ Obstet Gynecol2000，183，1： | 1 |
| 17 | Metal complexes of a picolinate-based nitronyl nitroxide free radical显示文摘 | Coronado E Gimenez-Saiz C M Romero F | 2009 | Inorg Chem2009，48，： | 1 |
| 18 | Rotational malalignmentof the components may cause chronic pain or early failure in total kneearthroplasty显示文摘 | Hofmann S Romero J Roth-Schiffl E | 2003 | Orthopade2003，32，6： | 1 |
| 19 | Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells显示文摘 | Romero IA Radewicz K Jubin E | 2003 | Neurosci Lett2003，344，： | 1 |
| 20 | Grid cell distortion and modflow' s integrated finit-difference numerical solution 显示文摘 | Romero D M Silver S E | 2006 | Groundwater2006，44，6： | 1 |
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