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| 1 | Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography显示文摘AIM:To investigate foveal avascular zone(FAZ) and parafoveal vessel densities(PRVD) by means of optical coherence tomography angiography(OCTA) in diabetic patients with or without diabetic retinopathy(DR) and to assess the reproducibility of FAZ and PRVD measurements.METHODS:Sixty diabetic patients(60 eyes) with different stage of DR(graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners.FAZ area in all patients was also assessed using fluorescein angiography(FA).RESULTS:In subject with proliferative DR and with moderate-severe non proliferative DR,FAZ area was significantly increased compared to healthy controls(P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA).OCTA showed significantly less inter-observer variability compared to FA.Concordance correlation coefficient(CCC) for FAZ area measurements was 0.829(95%CI:0.736-0.891) P<0.001 with FA and 1.000(95%CI:0.999-1.000) P<0.001 with OCTA.CCC was 0.834(95%CI:0.746-0.893) P<0.001 and 0.890(95%CI:0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements,respectively.CONCLUSION:OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity.FAZ area and PRVD measurements using OCTA are highly reproducible. | Rodolfo Mastropasqua Lisa Toto Alessandra Mastropasqua Raffaella Aloia Chiara De Nicola Peter A Mattei Guido Di Marzio Marta Di Nicola Luca Di Antonio | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 26 |
| 2 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 3 | Coronary artery anomalies overview: The normal and the abnormal显示文摘The aim of this review is to give a comprehensive and concise overview of coronary embryology and normal coronary anatomy, describe common variants of normal and summarize typical patterns of anomalous coronary artery anatomy. Extensive iconography supports the text, with particular attention to images obtained in vivo using non-invasive imaging. We have divided this article into three groups, according to their frequency in the general population: Normal, normal variant and anomaly. Although congenital coronary artery anomalies are relatively uncommon, they are the second most common cause of sudden cardiac death among young athletes and therefore warrant detailed review. Based on the functional relevance of each abnormality, coronary artery anomalies can be classified as anomalies with obligatory ischemia, without ischemia or with exceptional ischemia. The clinical symptoms may include chest pain, dyspnea, palpitations, syncope, cardiomyopathy, arrhythmia, myocardial infarction and sudden cardiac death. Moreover, it is important to also identify variants and anomalies without clinical relevance in their own right as complications during surgery or angioplasty can occur. | Adriana DM Villa Eva Sammut Arjun Nair Ronak Rajani Rodolfo Bonamini Amedeo Chiribiri | 2016 | World Journal of Radiology2016，8，6： | 14 |
| 4 | 前列腺癌Gleason分级目前进展的剖析显示文摘前列腺癌的Gleason评分是泌尿病理学的一个里程碑,它是从病理学角度估计前列腺癌预后必不可少的指标。在临床医师采用的如Partin tables或Kattan nomograms预测病理分期或前列腺根治术及放疗后的预后等多种方法中,Gleason评分[1-4]也都包括在内。对于未接受放化疗、前列腺根治术或其他物理或新辅助治疗的患者,它也可帮助预测前列腺根治术后局部复发以及淋巴结或远处转移的发生率[5-8]。 | 程亮 王曦 朱扬丽 张建民 Antonio Lopez-Beltran Rodolfo Montironi | 2011 | 中华病理学杂志2011，40，9： | 12 |
| 5 | Effects of urea plus nitrate pretreated rice straw and corn oil supplementation on fiber digestibility,nitrogen balance,rumen fermentation,microbiota and methane emissions in goats显示文摘Background: Urea pretreatment is an efficient strategy to improve fiber digestibility of low quality roughages for ruminants. Nitrate and oil are usually used to inhibit enteric methane(CH4) emissions from ruminants. The objective of this study was to examine the combined effects of urea plus nitrate pretreated rice straw and corn oil supplementation to the diet on nutrient digestibility, nitrogen(N) balance, CH4 emissions, ruminal fermentation characteristics and microbiota in goats. Nine female goats were used in a triple 3 × 3 Latin Square design(27 d periods). The treatments were: control(untreated rice straw, no added corn oil), rice straw pretreated with urea and nitrate(34 and 4.7 g/kg of rice straw on a dry matter [DM] basis, respectively, UN), and UN diet supplemented with corn oil(15 g/kg soybean and15 g/kg corn were replaced by 30 g/kg corn oil, DM basis, UNCO).Results: Compared with control, UN increased neutral detergent fiber(NDF) digestibility(P < 0.001) and copies of protozoa(P < 0.001) and R. albus(P < 0.05) in the rumen, but decreased N retention(-21.2%, P < 0.001), dissolved hydrogen concentration(-22.8%, P < 0.001), molar proportion of butyrate(-18.2%, P < 0.05),(acetate + butyrate) to propionate ratio(P < 0.05) and enteric CH4 emissions(-10.2%, P < 0.05). In comparison with UN, UNCO increased N retention(+34.9%, P < 0.001) and decreased copies of protozoa(P < 0.001) and methanogens(P < 0.001). Compared with control, UNCO increased NDF digestibility(+8.3%, P < 0.001), reduced ruminal dissolved CH4 concentration(-24.4%, P < 0.001) and enteric CH4 emissions(-12.6%, P < 0.05).Conclusions: A combination of rice straw pretreated with urea plus nitrate and corn oil supplementation of the diet improved fiber digestibility and lowered enteric CH4 emissions without negative effects on N retention. These strategies improved the utilization of rice straw by goats. | Xiumin Zhang Rodolfo F.Medrano Min Wang Karen A.Beauchemin Zhiyuan Ma Rong Wang Jiangnan Wen Lukuyu A.Bernard Zhiliang Tan | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 10 |
| 6 | Oral frailty and neurodegeneration in Alzheimer’s disease显示文摘Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s disease.Among different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical functions.We briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease neurodegeneration.Several underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral disease.Oral microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease risk.On this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s disease.Therefore,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty. | Vittorio Dibello Madia Lozupone Daniele Manfredini Antonio Dibello Roberta Zupo Rodolfo Sardone Antonio Daniele Frank Lobbezoo Francesco Panza | 2021 | Neural Regeneration Research2021，16，11： | 10 |
| 7 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 8 | 国际泌尿病理协会——2012年肾肿瘤进展共识显示文摘国际泌尿病理协会(International Society of Urological Pathology,ISUP)是泌尿病理的国际性权威参照组织。自1992年成立以来,协会已召集多次共识会议,对膀胱肿瘤的分类、前列腺腺癌的Gleason分级系统以及前列腺癌根治标本的处理和分期等问题提供了国际性的指南。 | 贺慧颖 Brett Delahunt John Srigley Lars Egevad Rodolfo Montironi 周敏 | 2014 | 临床与实验病理学杂志2014，30，6： | 8 |
| 9 | Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study显示文摘AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed'on demand'.Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score.Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles.Liver function can remain stable in the long-term, with optimal medium term survival.This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. | Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 10 | Mechanical Properties and Stress Strain Relationship Models for Bamboo Scrimber显示文摘In order to investigate the basic mechanical properties and stress strain relationship model for bamboo scrimber manufactured based on a new technique,a large quantities of experiments have been carried out.Based on the analysis of the test results,the following conclusions can be drawn.Two main typical failure modes were classified for bamboo scrimber specimens both under tension parallel to grain and tension perpendicular to grain.Brittle failure happened for all tensile tests.The slope values for the elastic stages have bigger discreteness compared with those for the specimens under tensile parallel to grain.The failure modes for bamboo scrimber specimens under compression parallel to grain could be divided into four.Only one main failure mode happened both for the bending specimens and the shear specimens.With the COV values of 28.64 and 25.72 respectively,the values for the strength and elastic modulus under tensile perpendicular to grain have the largest discreteness for bamboo scrimber.From the point of CHV values,the relationship among the mechanical parameters for bamboo scrimber were proposed based on the test results.Compared with other green building materials,bamboo scrimber manufactured based on a new technique has better mechanical performance and could be used in construction area.Three stress strain relationship models which are four-linear model,quadratic function model,and cubic function model were proposed for bamboo scrimber specimens manufactured based on a new technique.The latter two models gives better prediction for stress strain relationship in elastic plastic stage. | Haitao Li Huizhong Zhang Zhenyu Qiu Jingwen Su Dongdong Wei Rodolfo Lorenzo Conggan Yuan Hongzheng Liu Chungui Zhou | 2020 | Journal of Renewable Materials2020，8，1： | 7 |
| 11 | Compression Behaviors of Parallel Bamboo Strand Lumber Under Static Loading显示文摘In order to investigate the influence of length and compression directions upon behaviour of parallel bamboo strand lumber(PBSL)specimens,240 axial compression tests have been performed.With three similar one different typical failure modes,the mechanical performance for PBSL specimens under compression parallel to grain and perpendicular to grain are different as a whole.From the point of the characteristic values,the compression strength parallel to grain is 2.1 times of the compression strength perpendicular to grain.The elastic modulus for compression parallel to grain is 3.64 times of the compression strength perpendicular to grain.While the compression ratios along two compression directions are equal to each other.The bigger Poisson ratios for one typical side surface is 3.93 times of that for another typical side surface for PBSL specimens under compression perpendicular to grain,and the bigger value is equal to that for PBSL specimens under compression parallel to grain.Length can influence the mechanical properties of the PBSL specimens.The size 50 mm×50 mm×100 mm should be good choice for the standard or code to measure the compression strength.PBSL materials have better ductility under compression parallel to grain than that under compression perpendicular to grain.Stress-strain relationship models were proposed for PBSL specimens under compression parallel to grain and perpendicular to grain,respectively.These proposed models gave a good agreement with the test results. | Haitao Li Zhenyu Qiu Gang Wu Dongdong Wei Rodolfo Lorenzo Conggan Yuan Huizhong Zhang Rong Liu | 2019 | Journal of Renewable Materials2019，7，7： | 7 |
| 12 | 抗苗勒管激素作为卵巢颗粒细胞瘤肿瘤标记物的实验研究显示文摘目的 研究抗苗勒管激素 (anti mullerianhormone ,AMH)在诊断卵巢颗粒细胞瘤(granulosacelltumor,GCT)中作为特异性肿瘤标记物的实验依据。方法 采用免疫组织化学、原位杂交、Northern杂交法研究转基因小鼠早、晚期卵巢GCT中AMH及其受体mRNA的表达 ,并用放射性碘( 12 5I)标记法、Northern杂交法研究经培养的卵巢GCT细胞中AMH及其受体mRNA的表达。结果 转基因小鼠早期卵巢GCT中 ,AMH的免疫组织化学检测和AMH受体mRNA的原位杂交检测结果显示 ,两者的阳性表达率均为 10 0 % ;而晚期卵巢GCT中 ,两者的阳性表达均为 8例中 2例 ,分别比较 ,差异均有极显著性 (P <0 .0 1)。Northern杂交研究同样显示 ,早期卵巢GCT和卵巢GCT细胞AMH受体mRNA的阳性表达率均为 10 0 %。放射性自显影的研究显示 ,在卵巢GCT细胞膜处有放射性亮点 ,12 5I标记的AMH与卵巢GCT细胞结合率达 10 0 %。结论 AMH可作为一种特异性的肿瘤标记物 ;可用于卵巢疑难肿瘤的鉴别诊断以及早期卵巢GCT的诊断 ; | 龙雯晴 王伟民 Rodolfo REY 喇端端 季晓琼 | 2000 | 中华妇产科杂志2000，35，6： | 6 |
| 13 | Cutaneous manifestations of hepatitis C in the era of new antiviral agents显示文摘The association of chronic hepatitis C virus(HCV) infection with a wide spectrum of cutaneous manifestations has been widely reported in the literature, with varying strength of epidemiological association. Skin diseases which are certainly related with chronic HCV infection due to a strong epidemiological and pathogenetic association are mixed cryoglobulinemia, lichen planus and porphyria cutanea tarda. Chronic pruritus and necrolytic acral erythema are conditions that may share a possible association with HCV infection, while several immune-mediated inflammatory skin conditions, such as psoriasis, chronic urticaria and vitiligo, have been only anecdotally reported in the setting of chronic HCV infection. Traditional interferonbased treatment regimens for HCV infection are associated with substantial toxicity and a high-risk of immune-related adverse events, while the advent of new direct-acting antivirals with sustained virological response and improved tolerability will open the door for all-oral, interferon-free regimens. In the new era of these direct acting antivirals there will be hopefully a renewed interest in extra-hepatic manifestations of HCV infection. The aim of the present paper is to review the main cutaneous HCV-related disorders- mixed cryoglobulinemia, lichen planus, porphyria cutanea tarda and chronic pruritus- and to discuss the potential impact of new antiviral treatments on the course of these extrahepatic manifestations of chronic HCV infection. | Simone Garcovich Matteo Garcovich Rodolfo Capizzi Antonio Gasbarrini Maria Assunta Zocco | 2015 | World Journal of Hepatology2015，7，27： | 5 |
| 14 | Effects of physiological integration on defense strategies against herbivory by the clonal plant Alternanthera philoxeroides显示文摘Aims The plant-herbivore interaction is one of the most fundamental inter-actions in nature.Plants are sessile organisms,and consequently rely on particular strategies to avoid or reduce the negative impact of herbivory.Here,we aimed to determine the defense strategies against insect herbivores in the creeping invasive plant Alternanthera philoxeroides.Methods We tested the defense response of A.philoxeroides to herbivory by a leaf-feeding specialist insect Agasicles hygrophila and a pol-yphagous sap-feeding insect Planococcus minor.We also tested the mechanisms triggering defense responses of A.philoxeroides by including treatments of artificial leaf removal and jasmonic acid application.Furthermore,we examined the effect of physiological integration on these defense strategies.Important Findings The combination of artificial leaf removal and jasmonic acid appli-cation produced a similar effect to that of leaf-feeding by the real herbivore.Physiological integration influenced the defense strat-egies of A.philoxeroides against herbivores,and increased biomass allocation to aboveground parts in its apical ramets damaged by real herbivores.Our study highlights the importance of physio-logical integration and modular plasticity for understanding the consequences of herbivory in clonal plants. | Rubén Portela Bi-Cheng Dong Fei-Hai Yu Rodolfo Barreiro Sergio R.Roiloa | 2019 | Journal of Plant Ecology2019，12，4： | 5 |
| 15 | Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies显示文摘Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and dissemination.Besides the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and leukocytes.The neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor cells.Strikingly,tumor-associated nerve fibers can guide cancer cell dissemination.Moreover,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor microenvironment.These leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic effect.Furthermore,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane proteins.Altogether,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer cells.Inspired by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced neurogenesis.Here we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based therapies.Small molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis. | Rodolfo Daniel Cervantes-Villagrana Damaris Albores-García Alberto Rafael Cervantes-Villagrana Sara Judit García-Acevez | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 16 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 17 | Endotics system vs colonoscopy for the detection of polyps显示文摘AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation. | Emanuele Tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria | 2010 | World Journal of Gastroenterology2010，16，43： | 5 |
| 18 | 2004 WHO Classification of the Renal Tumors of the Adults显示文摘 | Antonio Lopez-Beltran Marina Scarpelli Rodolfo Montironi Ziya Kirkali | 2005 | European Urology2005，，5： | 4 |
| 19 | Structure-activity relationship in water-gas shift reaction over gold catalysts supported on Y-doped ceria显示文摘The utilization of pure hydrogen as an energy source in fuel cells gave rise to renewed interest in developing active and stable water-gas shift catalysts. Gold catalysts have proven to be very efficient for water-gas shift reaction at low temperature. The aim of the present study was to investigate the effect of:(i) different preparation methods(impregnation and coprecipitation) to obtain a modified ceria support,and(ii) the amount of Y_2 O_3(1.0 wt%, 2.5 wt%, 5.0 wt% and 7.5 wt%) as dopant on the water-gas shift activity of Au/CeO_2 catalysts. An extended characterization by means of S_(BET), XRD, HRTEM/HAADF, FTIR,H_2-TPR and CO-TPR measurements in combination with careful evaluation of the catalyst behavior allowed to shed light on the parameters governing the water-gas shift activity. The catalysts show very high activity(>90% CO conversion) in the temperature range 180-220 ℃,with a slightly better performance of the gold catalysts on supports prepared by impregnation. The decreased activity with increasing Y_2 O_3 concentration is related to the hindering of oxygen mobility due to ordering of surface oxygen vacancies in vicinity of segregated Y^(3+). The effect of catalyst pre-treatments and the stability of the best performing samples were examined as well. | Tatyana Tabakova Lyuba Ilieva Ivan Ivanov Maela Manzoli Rodolfo Zanella Petya Petrova Zbigniew Kaszkur | 2019 | Journal of Rare Earths2019，37，4： | 4 |
| 20 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
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