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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | The Effect of Cannabidiol and URB597 on Conditioned Gaping(a Model of Nausea)Elicited by a Lithium-Paired Context in the Rat显示文摘 | Rock E M Limebeer C L Mechoulam R | 2008 | Psychopharmacology (Berl)2008，196，3： | 1 |
| 3 | Carotenoid update显示文摘 | Rock C L | 2003 | Journal of the American Dietetic Association2003，103，： | 1 |
| 4 | Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules显示文摘 | Rock KL Gramm C Rothstein L | 1994 | Cell1994，78，5： | 1 |
| 5 | Effect of light and reductones on differentiation of pleurotus ostreatus 显示文摘 | Seung rock L Woo-jeong J Yong-un B | 2011 | Journal of microbiology (Seoul Korea)2011，49，1： | 1 |
| 6 | The SCL - 90 and the MMPI: a step in the validation of a new self- report scale 显示文摘 | Derogatis L R Rickels K Rock A F | 1976 | British Journal of Psychiatry1976，128，： | 1 |
| 7 | A family of human receptor structurally related to Drosophila Toll 显示文摘 | Rock F L Hardium G Timans J C | 1998 | Proc NatlAcad Sci USA1998，95，： | 1 |
| 8 | Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate,develop effector function,and differentiate into memory cells显示文摘 | Pozzi L A Maciaszek J W Rock K L | 2005 | J Immunol2005，175，4： | 1 |
| 9 | Nutrition and physical activity guidelines for cancer survivors显示文摘 | Rock C L Doyle C Demark Wahnefried W | | 0，，： | 1 |
| 10 | Associations among magnetic spectroscopy, apparent diffusion coefficients, and image-guided histopathology with special attention to radiation necrosis 显示文摘 | Rock JP Scarpace L Hearshen D | 2004 | Neurosurgery2004，54，5： | 1 |
| 11 | Isotopic assessment of sources and processes affecting sulfate and nitrate in surface water and ground water of Luxembourg显示文摘 | ROCK L MAYER B | 2002 | Isotopes in Environmental and Health Studies2002，38，： | 1 |
| 12 | P504S:a new mole-cular marker for the detection of prostate carcinoma显示文摘 | Woda B A Rock K L | 2001 | Am J Surg Pathol2001，25，： | 1 |
| 13 | Remote detection of forest damage显示文摘 | ROCK B N VOGELMANN J E WILLIAMS D L | 1986 | Bio-Science1986，，36： | 1 |
| 14 | Approval summary sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advancedrenal cell carcinoma 显示文摘 | Goodman V L Rock E P Dagher R | 2007 | Clin Cancer Res2007，13，5： | 1 |
| 15 | A family of human receptor structurally related to Drosophila Toll 显示文摘 | Rock F L Hardium G Timans J C | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 16 | Trends in mortality from coronary heart and cerebrovascular diseases in the Americas: 1970-2000显示文摘 | Rock iguez T Malvezzi M Chatenoud L | 2006 | Heart2006，92，4： | 1 |
| 17 | Prevemive managemellt of cerebrosplnal fluid leakage in translagyrinthine surgery显示文摘 | Meyerson L R Monsell E M Rock J R | 1996 | Laryngoscope1996，106，5： | 1 |
| 18 | Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas显示文摘 | Jiang Z Chu P G Woda B A Liu Q Balaji K C Rock K L | 2008 | Clin Cancer Res2008，14，： | 1 |
| 19 | A family of human receptors structurally related to Drosophila toll显示文摘 | Rock F L Hardiman G Timans J C | 1998 | Proc Acad Sic USA1998，95，2： | 1 |
| 20 | How dying cells alert the immune system to danger显示文摘 | KONO H ROCK K L | 2008 | Nat Rev Immunol2008，8，： | 1 |
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