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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of trichothecene mycotoxins on eukaryotic cells: A review显示文摘 | Rocha O Ansari K Doohan F M | 2005 | Food Additives and Contaminants2005，22，4： | 1 |
| 3 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 4 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 5 | Does gum chewing ameliorate Postoperative ileus? Results of a prospective, ran- domized, placebo controlled trial显示文摘 | Matros E Rocha F Zinner M | 2006 | J Am Coil Surg2006，202，5： | 1 |
| 6 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 7 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 8 | Brazilian Bromeliaceae species:isolation of arylpropanoid acid derivatives and antiradical potential显示文摘 | Rocha F D Yano M Cunha M R | 2010 | Rev Bras Farmacogn2010，20，2： | 1 |
| 9 | Microstructural Evolution at the Initial Stages of Continuous Annealing of Cold Rolled Dual phase Steels 显示文摘 | Rocha R O Melo T M F Pereloma E V | 2005 | Materials Science and Engineering2005，391，12： | 1 |
| 10 | Trace elements determination in edible seaweeds by an optimized and validated ICP-MS method显示文摘 | R6denas de la Rocha S S6nchez-Muniz F J G6mez-Juaristi M | 2009 | Journal of Food Composition and Analysis2009，22，4： | 1 |
| 11 | Carbon as a catalyst: Esterification of acetic acid with ethanol 显示文摘 | Rocha R P Pereira M F R Figueiredo J L | 2013 | Catalysis Today2013，，： | 1 |
| 12 | Mechanism of the synergistic effect ofamiodarone and fluconazole in Candida albicans显示文摘 | Gamarra S Rocha E M F Zhang Y Q | 2010 | Antimicrobial agents and chemotherapy2010，54，5： | 1 |
| 13 | Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis显示文摘 | Rocha M G Gomes V A Tanus-Santos J E Rosa-E-Silva J C Candido-Dos-Reis F J Nogueira A A | 2015 | Braz J Med Biol Res2015，48，： | 1 |
| 14 | The use of prealbumin concentration as a biomarker of nutritional status in treated phenylketonuric patients显示文摘 | Rocha J C Almeida M F Carmona C | 2010 | Ann Nutr metab2010，56，3： | 1 |
| 15 | The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzhe- imer' s disease 显示文摘 | Campos H C da Rocha M D Viegas F P | 2011 | CNS Neurol Disord Drug Targets2011，10，2： | 1 |
| 16 | Notch-dependent VEGFR3 up- regulation allows angiogenesis without VEGF-VEGFR2 signalling显示文摘 | Benedito R Rocha S F Woeste M Zamykal M Radtke F Casanovas O | 2012 | Nature2012，484，： | 1 |
| 17 | Volatile composition of Baga red wine: assessment of the identification of the would-be impact odoumnts显示文摘 | ROCHA S M RODRIGUES F COCO P | 2004 | Analytica Chimica Acta2004，513，1： | 1 |
| 18 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering A2005，391，： | 1 |
| 19 | Effects of trichothecenemycotoxins on eukaryotic cells: a review显示文摘 | ROCHA O ANSARI K DOOHAN F M | 2005 | Food Additives andContaminants2005，22，： | 1 |
| 20 | Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina显示文摘 | SANTOS A F D CAVADA B S ROCHA B A M D | 2010 | Bioresource Technology2010，101，2： | 1 |
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