|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 2 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Effects of trichothecene mycotoxins on eukaryotic cells: A review显示文摘 | Rocha O Ansari K Doohan F M | 2005 | Food Additives and Contaminants2005，22，4： | 1 |
| 5 | Detoxification of Aqueous Chlorophenol Solution by Ionizing Radiation显示文摘 | Rocha F | 2000 | Water Research2000，31，33： | 1 |
| 6 | Probiotic potential of Mi-nas fresh cheese prepared with the addition of Lactobacillus paracasei显示文摘 | Buriti F A da Rocha J S Assis E G | | 0，，02： | 1 |
| 7 | Probiotic potential of Minas fresh cheese prepared with the addition of Lactobacillus paracasei 显示文摘 | BURITI F C A DA ROCHA J S ASSIS E G | 2005 | Lebensmittel-Wissenschaft und Tehonlogie2005，38，2： | 1 |
| 8 | Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study显示文摘 | Kurreeman F A S Rocha D Houwing-Duistermaat J | 2008 | Arthritis &Rheumatism2008，58，9： | 1 |
| 9 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 10 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 11 | Does gum chewing ameliorate Postoperative ileus? Results of a prospective, ran- domized, placebo controlled trial显示文摘 | Matros E Rocha F Zinner M | 2006 | J Am Coil Surg2006，202，5： | 1 |
| 12 | Detection of rabbit haemorrhagic disease virus (RHDV) in nonspeeificverteb- rate hosts sympatric to the European wild rabbit (Oryctolagus cuniculus)显示文摘 | Merchan T Rocha G Alda F | 2011 | Infect Genet Evol2011，，11： | 1 |
| 13 | Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish(Danio rerio)显示文摘 | Rocha F Dias J Engrola S | 2014 | The Journal of Experimental Biology2014，217，7： | 1 |
| 14 | Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease显示文摘 | Locatelli F Rocha V Reed W | | 0，，06： | 1 |
| 15 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 16 | Editorial Comment to Chronic bacterial seminal vesiculitis as a potential disease entity in men with chronic prostatitis 显示文摘 | Andrade Rocha F T | 2015 | International Journal of Urology2015，22，5： | 1 |
| 17 | Differentially expressed angiogenic genes in diabetic erectile tissue-results from a microarray screening显示文摘 | CASTELA A SOARES R ROCHA F | 2012 | Mol Genet Metab2012，105，2： | 1 |
| 18 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 19 | Hemostatic changes in systemic inflanrnmatory response syndrome during continuous renal replacement therapy显示文摘 | Garcia-Femdndez N Lavilla F J Rocha E | 2000 | J Nephrol2000，13，4： | 1 |
| 20 | Wet depositionand related atmospheric chemistry in the S(a)o Paulo Metropolis,Brazil:Part 1-Major inorganic ions in rainwater as evaluated by capillary electrophoresis with contactless conductivity detection显示文摘 | F R Rocha S Fracassi A José | 2003 | Atmos Environ2003，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员