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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 3 | Retention of metal ions in ultrafiltration of mixtures of divalent metal ions and water-soluble polymer at constant ionic strength based on Freundlich and Langmuir isotherms显示文摘 | MORENO V I RIVAS B L | 2003 | Membrane Sci2003，215，12： | 1 |
| 4 | Long-term molecular remission with persistence of BCR-ABLl-specific cytotoxicTcells following imatinib withdrawal in an elderly patient with Philadelphia-positive ALL显示文摘 | Riva G Luppi M Lagreca I | 2014 | Br J Haematol2014，164，2： | 1 |
| 5 | Analysis of the simultaneous catalytic combustion of chlorinated aliphatic pollutants and toluene over ceria-zirconia mixed oxides 显示文摘 | Beatriz de Rivas Jose I Gutierrez-Ortiz Ruben LopezFonseca | 2006 | Applied Catalysis A2006，，： | 1 |
| 6 | Product formation from thiophene by a mixed bacterial culture:Influence of benzene as growth sub- strate 显示文摘 | Rivas I M Mosbaek H Arvin E | 2003 | Water Research2003，37，12： | 1 |
| 7 | SNPper:retrieval and analysis of human SNPs显示文摘 | Riva A Kohane I S | 2002 | Bioinformatics2002，18，12： | 1 |
| 8 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 9 | Cloning,production,purification and preliminary crystallographic analysis of a glycosidase from the food lactic acid bacterium Lactobacillus plantarum CECT 748(T)显示文摘 | ACEBRON I CURIEL J A DE LAS RIVAS B | | 0，，02： | 1 |
| 10 | Side stream biofilm for improved biofouling control in cooling water system显示文摘 | RIVAS I M ARVIN F | 2001 | Wat Sci Tech2001，41，： | 1 |
| 11 | Mononuclear phagocytic cells in human milk:HLA-DR and Fc gamma R ligand expression显示文摘 | Rivas R A A A el-Mohandes I M Katona | 1994 | Biol Neonate1994，66，4： | 1 |
| 12 | Speciation of cationic arsenic species in seafood by coupling liquid chromatogramphy with hydride generateon atomic fluorescence detection显示文摘 | SUNER M A DEVESA V RIVAS I | 2000 | J Anal At Spectrom2000，15，： | 1 |
| 13 | Chem- ical recycling of post-consumer PET wastes by glycolysis in the presence of metal salts 显示文摘 | Lopez-Fonseca R Duque-Ingunza I De Rivas B | 2010 | Polym Degrad Stabil2010，95，6： | 1 |
| 14 | Development and validation of a fast high-performance liquid chromatography method for the determination of microencapsulated pyrethroid pesticides显示文摘 | Rivas I P Gil AIegre M E Torres-Suarez A I | 2006 | Anal Chim Acta2006，557，： | 1 |
| 15 | Targeting to macrophages:role of physicochemical properties ofparticulate carriers-liposomes and microspheres-on the phagocytosis by macrophages 显示文摘 | AHSAN F RIVAS I P KHAN M A | 2002 | Control Rel2002，79，13： | 1 |
| 16 | A new approach for separating low-molecular-weight RNA molecules by staircase electrophoresis in non-sequencing gels显示文摘 | ENCARNA VEL(A)ZQUEZ RA U1 RIVAS MAR(I)A DEL VILLAR | 2006 | Electrophoresis2006，27，： | 1 |
| 17 | Isothermal calorimetry approach to evaluate shelf life of foods显示文摘 | Riva M Fessas D Schirald i A | 2001 | Thermochimica Acta2001，370，： | 1 |
| 18 | Pesticide exposure of two age groups of women and its relationship with their diet显示文摘 | Rivas A Cerrillo I Granada A | 2007 | Science of the Total Environment2007，382，1： | 1 |
| 19 | Genetic control of morpho- genesis-Hox induced organogenesis of the posterior spiracles 显示文摘 | Hombria i C G Rivas M L Sotillos S | 2009 | Int J Dev Biol2009，53，810： | 1 |
| 20 | Analysis of the retention profiles o{ poly(acrylic acid) with Co(Ⅱ) and Ni(Ⅱ) 显示文摘 | Rivas BL Moreno- Villoslada I | 1997 | Polym Bull1997，39，： | 1 |
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