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| 1 | Anal plugs and retrograde colonic irrigation are helpful in fecal incontinence or constipation显示文摘AIM: To evaluate the feasibility, clinical effect and predicting factors for favorable outcome of treatment with anal plugs in fecal incontinence and retrograde colonic irrigation (RCI) in patients with fecal incontinence or constipation. METHODS: Patients who received treatment with an anal plug or RCI between 1980 and 2005 were investigated with a questionnaire. RESULTS: Of the 201 patients (93 adults, 108 children), 101 (50/) responded. Adults: anal plugs (8), five stopped immediately, one stopped after 20 mo and two used it for 12-15 mo. RCI (40, 28 fecal incontinence, 12 constipation), 63/ are still using it (mean 8.5 years), 88/ was satisfied. Younger adults (< 40 years) were more satisfied with RCI (94 / vs 65/, P = 0.05). Children: anal plugs (7), 5 used it on demand for an average of 2.5 years with satisfactory results, one stopped immediately and one after 5 years. RCI (26 fecal incontinence, 22 constipation), 90/ are still using it (mean time 6.8 years) and felt satisfi ed. Children tend to be more satisfi ed (P = 0.001). Besides age, no predictive factors for success were found. There was no difference in the outcome between patients with fecal incontinence or constipation. CONCLUSION: RCI is more often applied than anal plugs and is helpful in patients with fecal incontinence or constipation, especially for younger patients. Anal plugs can be used incidentally for fecal incontinence, especially in children. | Marcel Cazemier Richelle JF Felt-Bersma Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，22： | 4 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 4 | Radiofrequency Lesion Adjacent to the Dorsal Root Ganglion for Cervicobrachial Pain: A Prospective Double Blind Randomized Study显示文摘 | Maarten van Kleef Leon Liem Richel Lousberg Gerard Barendse Fons Kessels Menno E. Sluijter | 1996 | Neurosurgery1996，，6： | 2 |
| 5 | Neurological heterotopic ossification:novel mechanisms,prognostic biomarkers and prophylactic therapies显示文摘Neurological heterotopic ossification(NHO)is a debilitating condition where bone forms in soft tissue,such as muscle surrounding the hip and knee,following an injury to the brain or spinal cord.This abnormal formation of bone can result in nerve impingement,pain,contractures and impaired movement.Patients are often diagnosed with NHO after the bone tissue has completely mineralised,leaving invasive surgical resection the only remaining treatment option.Surgical resection of NHO creates potential for added complications,particularly in patients with concomitant injury to the central nervous system(CNS).Although recent work has begun to shed light on the physiological mechanisms involved in NHO,there remains a significant knowledge gap related to the prognostic biomarkers and prophylactic treatments which are necessary to prevent NHO and optimise patient outcomes.This article reviews the current understanding pertaining to NHO epidemiology,pathobiology,biomarkers and treatment options.In particular,we focus on how concomitant CNS injury may drive ectopic bone formation and discuss considerations for treating polytrauma patients with NHO.We conclude that understanding of the pathogenesis of NHO is rapidly advancing,and as such,there is the strong potential for future research to unearth methods capable of identifying patients likely to develop NHO,and targeted treatments to prevent its manifestation. | Ker Rui Wong Richelle Mychasiuk Terence J.O’Brien Sandy R.Shultz Stuart J.McDonald Rhys D.Brady | 2020 | Bone Research2020，8，4： | 2 |
| 6 | Coagulation factors Ⅶa and Ⅹa inhibit apoptosis and anoikis显示文摘 | Versteeg HH Spek CA Richel DJ | 2004 | Oncogene2004，23，2： | 1 |
| 7 | Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer显示文摘 | M. C. C. M. Hulshof P. M. A. Van Haaren J. J. B. Van Lanschot D. J. Richel P. Fockens S. Oldenborg E. D. Geijsen M. I. Van Berge Henegouwen J. Crezee | 2009 | International Journal of Hyperthermia2009，，1： | 1 |
| 8 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 9 | Populationpharmacokinetics and pharmacodynamics of paclitaxeland carboplatin in ovarian cancer patients:a study by theEuropean organization for research and treatment ofcancer-pharmacology and molecular mechanisms groupand new drug development group 显示文摘 | Joerger M Huitema A D Richel D J | 2007 | Clin Cancer Res2007，13，21： | 1 |
| 10 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma:a double-blind randomised phase 3 study显示文摘 | Kindler HL Ioka T Richel DJ | | 0，，03： | 1 |
| 11 | Systemic treatment of oesophageal cancer显示文摘 | RICHEL D J VERVENNE W L | 2004 | Eur Gastrocnterol Hepatol2004，16，3： | 1 |
| 12 | Plasma kinetics in man of epicatechin from black chocolate显示文摘 | RICHELLE M TAVAZZI L ENSLEN M | 1999 | Eur J Clin Nutr1999，53，： | 1 |
| 13 | Synthesis and optical properties of opal and inverse opal photonic crystals显示文摘 | Johnson N P McComb D W Richel A | 2001 | Synthetic Metal2001，116，： | 1 |
| 14 | The developing caneer stern-cell model: clinical challenges and opportunities 显示文摘 | Vermeulen L de Sousa e Melo F Richel DJ | 2012 | Lancet Oncol2012，13，2： | 1 |
| 15 | Molecular Prognostic Factors in Adenocarcinoma of the Esophagus and Gastroesophageal Junction 显示文摘 | LAGARDE SM TEN KATE FJW RICHEL DJ | 2007 | Ann Surg Oncol2007，14，2： | 1 |
| 16 | Investigation of anorectal function 显示文摘 | RICHELLE JF | 1988 | Br J Surgo1988，75，1： | 1 |
| 17 | Economic and environmental choices in the stabilization of atmospheric CO2 concentrations显示文摘 | Wigley Thomas M L Richard Richels | 1996 | Nature1996，379，6562： | 1 |
| 18 | Systemic treatment of oesophageal cancer 显示文摘 | Richel D J Vervenne WL | 2004 | Eur J Gastroenterol Hepatol2004，16，3： | 1 |
| 19 | A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma 显示文摘 | Wulfing C Machiels J P Richel D J | 2009 | Cancer2009，115，13： | 1 |
| 20 | On stabilizing CO2 concentrationscost-effective emission reduction strategies显示文摘 | Manne Alan S Richard Richels | 1997 | Environmental Modeling & Assessment1997，2，4： | 1 |
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