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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 3 | A systematic review on the aboveground biomass and carbon stocks of Indian forest ecosystems显示文摘Background:Tropical forests play a crucial role as source and sink in global carbon cycle.Development and other anthropogenic activities have led to degradation of forest land,and ultimately,it results in loss of biodiversity and increases concentration of CO_(2) in atmospheres.Therefore,there is urgent need to estimate regional and national level carbon stock for making forest-based policies and strategies for mitigation of CO_(2).Patchy and sporadic information is available on biomass and carbon stock of Indian forests.The paper presents a systematic review and comprehensive account of studies conducted in different forest types in India.Result:There are six major forest types found in India consisting of 15 groups and other subgroups with peculiar characteristics.Methodologies used by researchers for biomass/carbon stock estimation are destructive,nondestructive,tree inventories data,species-specific biomass estimation,and remote sensing.Majority of estimates are based on nondestructive allometric equation approach.Studies showed positive correlation between tree species,diameter at breast height,and biomass/carbon stock.Small-and medium-sized growing trees,invasive species,mixed forest,Agroforestry,and Agrosilviculture also play an important role in atmospheric carbon assimilation.The results of diverse forest carbon stock studies are broadly categorized in North,Central,and Southern India.Present review will be helpful for developing conservation policies and decision to increase carbon stock and also REDD+program for particular forest ecosystem.Conclusion:The systematic literature review was carried out to gather and summarize information from different studies conducted on forest ecosystems and quantification methods used for biomass estimation and carbon stock in different forests types and states of India.In general,great variability occurs in aboveground biomass and carbon stock on account of climatic and geographic differences.To obtain good and accurate estimations,following nondestructive approach,species-specific density-based equations are required from different habitats and also in relation to degradation status of forests.As such regional volume equations would increase error of estimations.The comprehensive account of data would be helpful to formulate strategies based on carbon sequestration in Indian forests for CO_(2) mitigation. | Onkar Salunkhe P.K.Khare Richa Kumari M.L.Khan | 2018 | Ecological Processes2018，7，1： | 4 |
| 4 | 不同贮存条件对肾素和醛固酮浓度测定的影响显示文摘目的:探讨不同贮存条件对血浆肾素浓度(plasma renin concentration,PRC)和醛固酮浓度(plasma aldosterone concentration,PAC)测定的影响。方法:取43名受试者血浆,各分为11份,其中1份立即测定PRC、PAC(基线值),另10份分别置室温3 h、6 h、24 h;4℃3 h、6 h、24 h;-20℃24 h、1个月、3个月;-80℃3个月测量PRC及PAC。依据基线PRC或PAC三分位进行分组,即低、中、高浓度组,进行亚组分析。结果:室温放置样本24 h期间,PRC随放置时间延长呈明显下降趋势(F=24.300,P=0.000),亚组分析显示中、高浓度组PRC自6 h起差异有统计学意义(P<0.05)。4℃放置24 h期间,PRC随放置时间延长呈显著上升趋势(F=33.600,P=0.000),亚组分析显示低、中浓度组PRC在3 h差异有统计学意义(P<0.05),高浓度组PRC在24 h差异有统计学意义(P=0.042)。-20℃、-80℃放置3个月期间,PRC无明显变化。样本置室温24 h、4℃24 h、-20℃3个月、-80℃3个月期间,PAC均无明显变化。结论:血浆室温放置PRC随时间逐渐降低,而4℃放置PRC随时间逐渐升高,-20℃、-80℃贮存对PRC测定无明显影响,且3个月内不受贮存时间影响。标本贮存温度3个月内对PAC测定无明显影响。 | 李溪月 Richa Goswami 胡金波 王越 宋颖 何文雯 杨淑敏 程庆丰 甄乾娜 李启富 | 2016 | 重庆医科大学学报2016，41，11： | 4 |
| 5 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013显示文摘 | Michele Baccarani Michael W. Deininger Gianantonio Rosti Andreas Hochhaus Simona Soverini Jane F. Apperley Francisco Cervantes Richard E. Clark Jorge E. Cortes Fran?ois Guilhot Henrik Hjorth-Hansen Timothy P. Hughes Hagop M. Kantarjian Dong-Wook Kim Richa | 2013 | Blood2013，，6： | 3 |
| 6 | ICESat/GLAS-derived changes in the water level of Hulun Lake, Inner Mongolia, from 2003 to 2009显示文摘Hulun Lake is the largest freshwater lake innorthern Inner Mongolia and even minor changes in itslevel may have major effects on the ecology of the lake andthe surrounding area. In this study, we used high-precisionelevation data for the interval from 2003-2009 measuredby the Geoscience Laser Altimetry System (GLAS) onboard the Ice, Cloud, and land Elevation Satellite (ICESat)to assess annual and seasonal water level variations ofHulun Lake. The altimetry data of 32 satellite tracks wereprocessed using the RANdom SAmple Consensus algo-rithm (RANSAC) to eliminate elevation outliers, andsubsequently the Normalized Difference Water Index(NDWI) was used to delineate the area of the lake. From2003-2009, the shoreline of Hulun Lake retreatedwestwards, which was especially notable in the southernpart of the lake. There was only a small decrease in waterlevel, from 530.72 m to 529.22 m during 2003-2009, anaverage rate of 0.08 m/yr. The area of the lake decreased ata rate of 49.52 km^2/yr, which was mainly the result of theshallow bathymetry in the southern part of the basin. Thedecrease in area was initially rapid, then much slower, andfinally rapid again. Generally, the lake extent and waterlevel decreased due to higher temperatures, intenseevaporation, low precipitation, and decreasing runoff.And their fluctuations were caused by a decrease in intra-annual temperature, evaporation, and a slight increase inprecipitation. Overall, a combination of factors related toclimate change were responsible for the variations of thewater level of Hulun Lake during the study interval. Theresults improve our understanding of the impact of climatechange on Hulun Lake and may facilitate the formulationof response strategies. | Chunlan LI Jun WANG Richa HU Shan YIN Yuhai BAO Yuwei LI | 2018 | Frontiers of Earth Science2018，12，2： | 3 |
| 7 | Endoscopic imaging:How far are we from real-time histology?显示文摘Currently,in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial surface.These 'optical biopsy' technologies offer the potential to improve diagnostic accuracy and yield,while facilitating real-time decision-making.Although many endoscopic techniques have preliminarily shown high accuracy rates,these technologies are still evolving.This review will provide an overview of the most promising high-resolution imaging technologies,including high resolution microendoscopy,optical coherence tomography,endocytoscopy and confocal laser endoscopy.This review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett's esophagus,ulcerative colitis and colorectal cancer. | Richa Shukla Wasif M Abidi Rebecca Richards-Kortum Sharmila Anandasabapathy | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 3 |
| 8 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 9 | Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival显示文摘Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria. | Puneet Gandhi Richa Khare Nitin Garg Sandeep Sorte | 2017 | World Journal of Clinical Cases2017，5，6： | 2 |
| 10 | Unique case of oligoastrocytoma with recurrence and grade progression:Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase显示文摘Mixed gliomas, primarily oligoastrocytomas, account for about 5%-10% of all gliomas. Distinguishing oligoastrocytoma based on histological features alone has limitations in predicting the exact biological behavior, necessitating ancillary markers for greater specificity. In this case report, human telomerase reverse transcriptase(hT ERT) and high mobility group-A1(HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma. Customized florescence-based immunohistochemistry protocol with enhanced sensitivity and specificity is used in the study. The patient presented with a history of generalized seizures and his magnetic resonance imaging scans revealed infiltrative ill-defined mass lesion with calcified foci within the left frontal white matter, suggestive of glioma. He was surgically treated at our center for four consecutive clinical events. Histopathologically, the tumor was identified as oligoastrocytoma-grade Ⅱ followed by two recurrence events and final progression to grade Ⅲ. Overall survival of the patient without adjuvant therapy was more than 9 years. Glial fibrillary acidic protein, p53, Ki-67, nuclear atypia index, pre-operative neutrophillymphocyte ratio, are the other parameters assessed. Findings suggest that hT ERT and HMGA1 are linked to tumor recurrence and progression. Established markers can assist in defining precise histopathological grade in conjuction with conventional markers in clinical setup. | Puneet Gandhi Richa Khare Kavita Niraj Nitin Garg Sandeep K Sorte Hanni Gulwani | 2016 | World Journal of Clinical Cases2016，4，9： | 2 |
| 11 | Viral Genotypes and Associated Risk Factors of Hepatocellular Carcinoma in India显示文摘Objective This study aims to investigate the etiological relationship among hepatitis B virus(HBV),hepatitis C virus(HCV),and alcohol as risk factors in a cohort of hepatocellular carcinoma(HCC) patients from India.The clinical and biochemical profiles and tumor characteristics in the HCC cases were also evaluated. Methods A total of 357 consecutive cases of HCC fulfilling the diagnostic criteria from the Barcelona-2000 EASL conference were included in the study.The blood samples were evaluated for serological evidence of HBV and HCV infection,viral load,and genotypes using serological tests,reverse transcription-polymerase chain reaction,and restriction fragment length polymorphism. Results The male/female ratio for the HCC cases was 5.87:1.Majority of the HCC patients(33.9% ) were 50 to 59 years of age,with a mean age of 4±13.23 years.More than half the cases(60.8% ) had underlying cirrhosis at presentation.Among the HCC patients,68.9% were HBV related,21.3% were HCV related,18.8% were alcoholic,and 18.2% were of cryptogenic origin.The presence of any marker positive for HBV increased the risk for developing HCC by almost 27 times[OR:27.33;(12.87-60.0)].An increased risk of 10.6 times was observed for HCC development for cases positive for any HCV marker[OR:10.55;(3.13-42.73)].Heavy alcohol consumption along with HCV RNA positivity in cirrhotic patients was found to be a risk for developing HCC by 3 folds[OR:3.17;(0.37-70.71)]. Conclusions Patients of chronic HBV infection followed by chronic HCV infection were at higher risk of developing HCC in India. Chronic alcohol consumption was found to be a risk factor in cirrhotic cases only when it was associated with HCV RNA positivity. Most of the patients had a large tumor size(>5 cm) with multiple liver nodules,indicating an advanced stage of the disease thus making curative therapies difficult. | Manash Pratim Sarma Mohammad Asim Subhash Medhi Thayumanavan Bharathi Richa Diwan Premashis Kar | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 2 |
| 12 | Cowpea NAC1/NAC2 transcription factors improve growth and tolerance to drought and heat in transgenic cowpea through combined activation of photosynthetic and antioxidant mechanisms显示文摘NAC(NAM/ATAF1/2/CUC2)transcription factors are central switches of growth and stress responses in plants.However,unpredictable interspecies conservation of function and regulatory targets makes the well-studied NAC orthologs inapt for pulse engineering.The knowledge of suitable NAC candidates in hardy pulses like cowpea(Vigna unguiculata(L.)Walp.)is still in infancy,hence warrants immediate biotechnological intervention.Here,we showed that overexpression of two native NAC genes(VuNAC1and VuNAC2)promoted germinative,vegetative,and reproductive growth and conferred multiple abiotic stress tolerance in a commercial cowpea variety.The transgenic lines displayed increased leaf area,thicker stem,nodule-rich denser root system,early flowering,higher pod production(~3.2-fold and~2.1-fold),and greater seed weight(10.3%and 6.0%).In contrast,transient suppression of VuNAC1/2 caused severe growth retardation and flower inhibition.The overexpressor lines showed remarkable tolerance to major yielddeclining terminal stresses,such as drought,salinity,heat,and cold,and recovered growth and seed production by boosting photosynthetic activity,water use efficiency,membrane integrity,Na^(+)/K^(+)homeostasis,and antioxidant activity.The comparative transcriptome study indicated consolidated activation of genes involved in chloroplast development,photosynthetic complexes,cell division and expansion,cell wall biogenesis,nutrient uptake and metabolism,stress response,abscisic acid,and auxin signaling.Unlike their orthologs,VuNAC1/2 direct synergistic transcriptional tuning of stress and developmental signaling to avoid unwanted trade-offs.Their overexpression governs the favorable interplay of photosynthesis and reactive oxygen species regulation to improve stress recovery,nutritional sufficiency,biomass,and production.This unconventional balance of strong stress tolerance and agronomic quality is useful for translational crop research and molecular breeding of pulses. | Richa Srivastava Yuriko Kobayashi Hiroyuki Koyama Lingaraj Sahoo | 2023 | Journal of Integrative Plant Biology2023，65，1： | 2 |
| 13 | Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients显示文摘BACKGROUND Inflammation is crucial to tumor progression.A traumatic event at a specific site in the brain activates the signaling molecules,which triggers inflammation as the initial response within the tumor and its surroundings.The educated immune cells and secreted proteins then initiate the inflammatory cascade leading to persistent chronic inflammation.Therefore,estimation of the circulating inflammatory indicators kynurenine(KYN),interleukin-6(IL-6),tissue-inhibitor of matrix-metalloproteinase-1 and human telomerase reverse transcriptase(hTERT)along with neutrophil-lymphocyte ratio(NLR)has prognostic value.AIM To assess the utility of chosen inflammatory marker panel in estimating systemic inflammation.METHODS The chosen markers were quantitatively evaluated in 90 naive,molecularly subtyped plasma samples of glioma.A correlation between the markers and confounders was assessed to establish their prognostication power.Follow-up on the levels of the indicators was done 3-mo post-surgery.To establish the validity of circulating KYN,it was also screened qualitatively by dot-immune-assay and by immunofluorescence-immunohistochemistry in tumor tissues.RESULTS Median values of circulating KYN,IL-6,hTERT,tissue-inhibitor of matrixmetalloproteinase-1 and NLR in isocitrate-dehydrogenase-mutant/wildtype and within the astrocytic sub-groups were estimated,which differed from controls,reaching statistical significance(P<0.0001).All markers negatively correlated with mortality(P<0.0001).Applying combination-statistics,the panel of KYN,IL-6,hTERT and NLR achieved higher sensitivity and specificity(>90%)than standalone markers,to define survival.The inflammatory panel could discriminate between WHO grades,and isocitrate-dehydrogenase-mutant/wildtype and define differential survival between astrocytic isocitrate-dehydrogenase-mutant/wildtype.Therefore,its assessment for precise disease prognosis is indicated.Association of KYN with NLR,IL-6 and hTERT was significant.Cox-regression described KYN,IL-6,NLR,and hTERT as good prognostic markers,independent of confounders.Multivariate linear-regression analysis confirmed the association of KYN and hTERT with inflammation marker IL-6.There was a concomitant significant decrease in their levels in a 3-mo follow-up.CONCLUSION The first evidence-based study of circulating-KYN in molecularly defined gliomas,wherein the tissue expression was found to be concomitant with plasma levels.A non-invasive model for assessing indicators of chronic systemic inflammation is proposed. | Puneet Gandhi Richa Shrivastava Nitin Garg Sandeep K Sorte | 2021 | World Journal of Clinical Oncology2021，12，10： | 2 |
| 14 | Gastric Hyperplastic Polyps: A Review显示文摘 | Richa Jain Runjan Chetty | 2009 | Digestive Diseases and Sciences2009，，9： | 2 |
| 15 | Highresolution distributed temperature sensing with the multiphoto-timing technique 显示文摘 | H o bel M Richa J Wtithrich M | 1995 | Applied Optics1995，34，16： | 1 |
| 16 | Management of complicated choledochal cysts显示文摘 | Lal Richa Agarwal Shaleen Shivhare Rakesh | | 0，，06： | 1 |
| 17 | Accessing Nearby Copies of Replicated Objects in a Distributed Environment 显示文摘 | Plaxton C G Raiaraman R Richa A W | 1999 | Theory of Computing Systems1999，32，3： | 1 |
| 18 | Dietary intake of pollutant aerosols via vegetables influenced by atmospheric depo- sition and wastewater irrigation 显示文摘 | Richa P Kumar S Jitendra P | 2012 | Ecotoxicology and Environmental Safety2012，76，： | 1 |
| 19 | Unified detection and tracking of instruments during retinal microsurgery显示文摘 | Sznitman R Richa R Taylor R | | 0，，05： | 1 |
| 20 | Suboptimal chlorine treatment of drinking water leads to selection of multidrug-resistant Pseudomonas acruginosa显示文摘 | Richa Shrivastava R K Upreti SR Ain | 2004 | Ecotoxicology and Environmental Safety2004，58，： | 1 |
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