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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Triiodothyronine and breast cancer显示文摘The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis. | Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 4 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 5 | Effect of heat-moisture treatment on rice starch of varying amylose content显示文摘 | Elessandra da Rosa Zavareze Cátia Regina Storck Luis Antonio Suita de Castro Manoel Artigas Schirmer Alvaro Renato Guerra Dias | 2009 | Food Chemistry2009，，2： | 1 |
| 6 | Bioactive amines and carbohydrate changes during ripening of 'Prata' banana (Musa acuminata ×M balbisiana)显示文摘 | Regina C | 2005 | Food Chemistry2005，90，： | 1 |
| 7 | Naphthenic Acids, Total Acid Number and Sulfur Content Profile Cha- racterization in Isthmus and Maya Crude Oils显示文摘 | GEORGINA C L CARLA R L REGINA E A | 2004 | Fuel2004，83，： | 1 |
| 8 | Algal bioaccumulation of triclocarban, triclosan, and methyt-triclosan in a North Texas wastewater treatment plant receiving stream显示文摘 | MELINDA A C REGINA E E THOMAS W L | 2007 | Chemosphere2007，67，10： | 1 |
| 9 | Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu显示文摘 | Cássia Regina Primila Cardoso Ilce Mara de Syllos Cólus Caroline Cristiane Bernardi Miriam Sannomiya Wagner Vilegas Eliana Aparecida Varanda | 2006 | Toxicology2006，，1： | 1 |
| 10 | Nitrogen compounds characterization in atmospheric gas oil and light cycleoil from a blend of Mexican crudes显示文摘 | Georgina C Laredo Sara Leyva Regina Alvarez | | 0，，： | 1 |
| 11 | Susceptibility to Vibrio cholerae Infection in a Cohort of Household Contacts of Patients with Cholera in Bangladesh显示文摘 | Jason B Harris Regina C LaRorocque Fahima Chowdhury | 2008 | Plos Neglected Tropical Diseases2008，2，4： | 1 |
| 12 | High-volmne peritoneal dialysis in acute kidney injury: indications and limitations 显示文摘 | Ponce D Berbel MN Regina de goes C | 2012 | Clin J Am Soc Nephrol2012，7，6： | 1 |
| 13 | Assessing the work environment for creativity显示文摘 | Amabile T M Regina C Heather C | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 14 | Assessing the work environment for creativity显示文摘 | Amabile T M Regina C Heather C | 1996 | Journa1996，39，5： | 1 |
| 15 | High-volume peritoneal dialysis in acute kidney injury:indications and limitations显示文摘 | Ponce D Berbel MN Regina de Goes C | 2012 | Clin J Am Soc Nephrol2012，7，6： | 1 |
| 16 | Assessing the WorkEnvironment for Creativity 显示文摘 | AMABILE T M REGINA C COON H | 1996 | The Academy of Management Jour-nal1996，39，5： | 1 |
| 17 | High-volume peritoneal dialysis in acute kidney injury:indications and limitations显示文摘 | Ponce D Berbel MN Regina de Goes C | | 0，，： | 1 |
| 18 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 19 | Carboxymethylation of cashew tree exudate polysaecharide 显示文摘 | I)URCII ENE A S REGINA C M JUDITH P A | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 20 | Comparison of Aluminum Coatings Deposited by Flame Spray and by Electric arc Spray 显示文摘 | Regina M H Ramon S C Schereiner H | 2007 | Surface and Coatings Technology2007，202，1： | 1 |
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