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| 1 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 2 | 4-Hydroxy-isoleucine improves insulin resistance by promoting mi-tochondrial biogenesis and act through AMPK and Akt dependent pathway显示文摘 | Rawat AK Korthikunta V Gautam S | 2014 | Fitoterapia2014，99，： | 1 |
| 3 | Feasibility study of aerosolized prosta-glandin E1 microspheres as a noninvasive therapy for pulmonary arterial hypertension显示文摘 | Gupta V Rawat A Ahsan F | | 0，，04： | 1 |
| 4 | Faceted and Vertically Aligned GaN Nanorod Arrays Fabricated without Catalysts or Lithography显示文摘 | Deb P Kim H Rawat V | 2005 | Nano Lett2005，5，： | 1 |
| 5 | Comparative pharmacognostic studies of three Phyllanthus species 显示文摘 | Khatoon S Rai V Rawat AKS | 2006 | J Ethnopharmacol2006，104，12： | 1 |
| 6 | 显示文摘 | Sampathumaran E V Das I Rawat R | 2000 | Appl Phys Lett2000，77，： | 1 |
| 7 | Semiological characteristics of adults with psychogenic nouepileptic seizures ( PNESs ) : an attempt towards a new classification显示文摘 | Dhiman V Sinha S Rawat VS | 2013 | Epilepsy Behav2013，27，3： | 1 |
| 8 | IgG4-related tubulointerstitial nephritis presenting with psychiatric manifestations and skin lesions显示文摘 | Ramachandran R Rajakumar V Rawat A | 2014 | Int Urol Nephrol2014，46，1： | 1 |
| 9 | Management of massive and nonmassive pulmonary embolism 显示文摘 | Sekhri V Mehta N Rawat N | 2012 | Arch Med Sci2012，8，6： | 1 |
| 10 | Action of Asparagus racemosus against streptozotocin-induced oxidative stress显示文摘 | Govindarajan R Vijayakumar M Rao CV Kumar V Rawat AKS Pushpangadan P | 2004 | Nat Prod Sci2004，10，4： | 1 |
| 11 | A new aliphatic ester from the aerial parts of Polygonum polystachyum 显示文摘 | Negi S Shukla V Rawat | 2005 | J Indian Chem Soc2005，82，8： | 1 |
| 12 | Faceted and vertically a- ligned GaN nanorod arrays fabricated without catalysts or lithography显示文摘 | Deb P Kim H Rawat V | 2005 | Nano Letters2005，5，9： | 1 |
| 13 | Inventory compilation and distribution of heavy metals in wastewater from small-scale industrial areas of Delhi, India显示文摘 | M Rawat M C Z Moturi V Subramanian | 2003 | J Environ Monit2003，5，6： | 1 |
| 14 | Children with psycho- genic non-epileptic seizures (PNES): A detailed semiologic a- nalysis and modified new classification显示文摘 | Dhiman V Sinha S Rawat VS | 2014 | Brain & Development2014，36，4： | 1 |
| 15 | Continuous-access guided communication (GAGC) for ground-guided transportation systems 显示文摘 | BEAL J C JOSIAK J M RAWAT V | 1973 | IEEE1973，61，5： | 1 |
| 16 | Calcination of Co-based Fischer-Tropsch synthesis catalysts显示文摘 | DE LOOSDRECHT J V BARRADAS S CARICATO E A NGWENYA N G NKWANYANA P S RAWAT M A S SIGWEBELA B H VAN BERGE P J VISAGIE J L | 2003 | Top Catal2003，26，14： | 1 |
| 17 | Management of massive and nonmassive pulmonary embolism显示文摘 | Sekhri V Mehta N Rawat N | 2012 | Arch Med Sci2012，8，6： | 1 |
| 18 | The vent -likehomeobox gene VENTX promotes human myeloid differentia-tion and is highly expressed in acute myeloid leukemia显示文摘 | RAWAT V P ARSENI N AHMED F | 2010 | Pro-ceedings of the National Academy of Sciences USA2010，107，16： | 1 |
| 19 | The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice 显示文摘 | SCHESSL C RAWAT V P CUSAN M | 2005 | J Clin Invest2005，115，： | 1 |
| 20 | A cryo-electron microscopic study of ribosome-bound termination factor RF2 显示文摘 | RAWAT U B ZAV1ALOV A V SENGUIYFA J ct al | 2003 | Nature2003，421，6918： | 1 |
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