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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 5 | The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy显示文摘 | KD Lindor C Bru RA Jorgensen J Rakela JM Bordas JB Gross J Rodes DB McGill CC Reading EM James JW Charboneau J Ludwig KP Batts AR Zinsmeister | 1996 | Hepatology1996，，5： | 2 |
| 6 | First total synthesis of Taxol 显示文摘 | HOLTON RA SOMOZA C KIM HB | 1994 | J Am Chem Soc1994，116，4： | 1 |
| 7 | Noninvasive Doppler derived myocardial perfonnance index:correlation with simultaneous measurements of cardiac catheterization measurement显示文摘 | Tei C Nishimura RA seward JB | 1997 | J Am Soc Echocardiogr1997，10，2： | 1 |
| 8 | Efficacy and safety of d, 1-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest显示文摘 | Haverkamp W Martines RA Hief C et ai | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 9 | Complete regression of wellestablished tumors using a novel water-soluble poly (L-glutamic acid)-paclitaxel conjugate显示文摘 | Li C Yu DF Newman RA | 1998 | Cancer Res1998，58，11： | 1 |
| 10 | Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos显示文摘 | Galloway JL Wingert RA Thisse C | 2005 | Dev Cell2005，8，1： | 1 |
| 11 | Correlation between inter-ictal regional cerebral blood flow and sphenoidal electrodes-recorded inter-ictal spikes in mesial temporal lobe epilepsy显示文摘 | Lemesle M Berriolo RA Touzery C | 2000 | Neurol-Res2000，22，7： | 1 |
| 12 | A novel culture morphology resulting from applied mechanical strain 显示文摘 | Grymes RA Sawyer C | 1977 | In Vitro Dev Biol Anim1977，33，5： | 1 |
| 13 | Translumbar emboliza- tion of type 2 endoleaks after endovascular repair of abdominal aortic aneurysms 显示文摘 | Baum RA Cope C Fairman RM | 2001 | J Vasc Interv Radiol2001，12，1： | 1 |
| 14 | Biochemical hallmarks of tyrosine hydroxylase deficiency显示文摘 | Br(a)utigam C Wevers RA Jansen RJ | | 0，，： | 1 |
| 15 | Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease显示文摘 | Feelders RA de Bruin C Pereira AM | 2010 | N Engl J Med2010，362，19： | 1 |
| 16 | Improved pa-tient/technique survival and peritonitis rates in pa-tients treated with automated peritoneal dialysis whencompared to continuous ambulatory peritoneal dialysisin a Mexican PD center 显示文摘 | Sanchez AR Madonia C Rascon-Pacheco RA | 2008 | Kidney Int2008，73，： | 1 |
| 17 | Assessing postoperative discomfort after third molar surgery: a prospec- tive study 显示文摘 | Grossi GB Maiorana C Garramone RA | 2007 | Oral Maxillofac Surg2007，65，： | 1 |
| 18 | Glycogen storage disease in adults显示文摘 | Talente GM Coleman RA Alter C | 1994 | Ann Intern Med1994，120，： | 1 |
| 19 | Automatic detection of residential buildings using LiDAR data and muhispectral imagery显示文摘 | Awra Ngjeb M Ra V Anbak Hs H M raser C S | 2010 | ISPRS Journal of Photogramme- try and Remote Sensing2010，65，5： | 1 |
| 20 | Biodiversity Hotspots for Conservation Priorities显示文摘 | MYEP~S N MITTERMEIER RA MITTEI~MEIEP C G | 2000 | Nature2000，403，672： | 1 |
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