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| 1 | The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis显示文摘Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth.This pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and LPA.The major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and establishment.TEAD also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug resistance.However,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo signaling.Thus,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer. | Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Raposo Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh | 2021 | Genes & Diseases2021，8，1： | 5 |
| 2 | 葡萄牙刑法中的医疗行为及医疗责任显示文摘葡萄牙刑法在刑事医疗责任上表现出一个非常有趣的特性:在特定要件下的医疗手术中,医生不会为对病人造成的伤害承担刑事责任。根据《葡萄牙刑法典》第150条第2款规定,符合本规范要件的医疗行为不会被认为是刑事罪行,即使病人死亡或受到伤害。《葡萄牙刑法典》第150条第2款还规定了一项具有创造性的刑事条款:医疗行为,如果违反了医疗职业规则,使病人的生命或健康处于风险状态,即使病人在该特定情形下并未遭受实际的伤害,该行为仍被认为是犯罪。本文中,笔者将会分析该项规则的运用问题。典型案例是2016年一例提交科英布拉上诉法院审理的外科手术后女性病人死亡的特殊刑事案件,并就刑事医疗责任问题提供目前葡萄牙的最新趋势展望。 | Vera Lucia Carapeto Raposo | 2017 | 法律适用2017，，12： | 2 |
| 3 | CAR-T cells: Early successes in blood cancer and challenges in solid tumors显示文摘New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully. | Hassan Dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo Thomas J.Webster | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 4 | Long-range magnetostatic interactions in arrays of nanowires显示文摘 | Raposo V Garcia J M Gonzalez J M | 2000 | J Magn Magn Mater2000，222，： | 2 |
| 5 | Automatically maintaining wrappers for semi-structured web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez Justo Hidalgo | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 6 | Biodegradation of p-chlorophenol by a microalgae consortium 显示文摘 | Sofia A C Lima M Filomena J Raposo | 2004 | Water Research2004，38，： | 1 |
| 7 | Giant magnetoimpedance effect enhancement by circuit matching显示文摘 | Raposo V | 2003 | Sensors and Actuators2003，106，： | 1 |
| 8 | Male breast cancer显示文摘 | GOMEZ RAPOSO C ZAMBRANA TfiVAR F SERENO MOYA-NO M | 2010 | Cancer Treat Rev2010，36，6： | 1 |
| 9 | Salivary and serum proteomics in head and neck carcinomas:before and after surgery and radiotherapy显示文摘 | Vidotto A Henrique T Raposo LS | | 0，，02： | 1 |
| 10 | The effect of fiber post presence and restomtive tecllIlique on thebiomechanical behavior of endodontically treatcd maxillaryincisors:an in vitro study显示文摘 | Valdivia AD Raposo LH Simamoto-Ju nior PC | 2012 | J Prosthet Dent2012，108，3： | 1 |
| 11 | Cortical subarachnoid haemorrhage in the elderly : a recurrent event probably related to cer- ebral amyloid angiopathy 显示文摘 | Raposo N Vignier A Cuvinciue V | 2011 | Eur J Neurol2011，18，4： | 1 |
| 12 | Extracellular vesicles: exosomes, microvesicles, and friends显示文摘 | Raposo G Stoorvogel W | 2013 | J Cell Biol2013，200，4： | 1 |
| 13 | Tumor - derived exosomes are a source of shared tumor rejection antigens for CTL cross - priming显示文摘 | Wolfers J Lozier A Raposo G | 2001 | Nat Med2001，7，3： | 1 |
| 14 | Influence of inoculum to substrate ratio on the biochemical methane potential of maize in batch tests显示文摘 | Raposo F Banks C J Siegert I | 2006 | Process Biochemistry2006，41，： | 1 |
| 15 | Production of biodiesel from waste frying oils显示文摘 | FELIZARDO P M NEIVA CORREIA J RAPOSO I et a1 | 2006 | Waste Management2006，26，5： | 1 |
| 16 | Mutation rates at 14 STR loci in the population from Pernambuco, Northeast Brazil显示文摘 | Andrade ES Comes EV Raposo G | 2009 | Forensic Sci Int Genet2009，3，4： | 1 |
| 17 | Tow independent regions of HIV-1NefR are required for connection with the endocytic pathway through binding to the mu1 chain of AP1 complex显示文摘 | Erdtmann L Raposo GJ | 2000 | Traffic2000，1，11： | 1 |
| 18 | The Use of Transversal Slot Anodes at ALBRAS Smelter 显示文摘 | Handerson Penna Dias Ronaldo Raposo de Moura | 2005 | Light Metals2005，，： | 1 |
| 19 | Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3) 显示文摘 | Feldmann J Callebaut I Raposo G | 2003 | Cell2003，115，4： | 1 |
| 20 | Exosomes--vesicular carriers for intercellular communication显示文摘 | Simons M Raposo G | 2009 | Curr Opin Cell Biol2009，21，57： | 1 |
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