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| 1 | A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation显示文摘Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over time.However,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation process.Here,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell behaviors.This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications. | Haitao Cui Shida Miao Timothy Esworthy Se-jun Lee Xuan Zhou Sung Yun Hann Thomas J.Webster Brent T.Harris Lijie Grace Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 2 | CAR-T cells: Early successes in blood cancer and challenges in solid tumors显示文摘New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully. | Hassan Dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo Thomas J.Webster | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 3 | Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond显示文摘Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface. | Yixing Tian Huiling Liu Brian W.Sheldon Thomas J.Webster Sichen Yang Huilin Yang Lei Yang | 2019 | Journal of Materials Science & Technology2019，35，5： | 1 |
| 4 | Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles显示文摘Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer treatment.For such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized radiotherapy.Herein,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray irradiation.Methotrexate(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release behavior.The designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal cells.Impressively,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications. | Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.Webster Behrooz Johari Hossein Danafar | 2022 | Bioactive Materials2022，7，1： | 0 |
| 5 | Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer显示文摘Cancer is one of the biggest healthcare concerns in our century,a disease whose treatment has become even more difficult following reports of drug-resistant tumors.When this happens,chemotherapy treatments fail or decrease in efficiency,leading to catastrophic consequences to the patient.This discovery,along with the fact that drug resistance limits the efficacy of current treatments,has led to a new wave of discovery for new methods of treatment.The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer.Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting.Consequently,these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting.This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers,including polymeric,viral,lipid-based,metal-based,carbon-based,and magnetic nanocarriers,opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors. | Aleksandra Benko David Medina-Cruz Ada Vernet-Crua Catherine P.O'Connell MałgorzataŚwiętek Hamed Barabadi Muthupandian Saravanan Thomas J.Webster | 2021 | Cancer Drug Resistance2021，4，2： | 0 |
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