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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Shoot and root growth cycles of avocado in South Florida 显示文摘 | Ploletz R C Ramos J L Pan'ado J L | 1991 | Florida State Horticultural Socie- ty1991，，104： | 1 |
| 3 | Role of cortical cell type and morphology in sub- and su- prathreshold uniform electric field stimulation in vitro 显示文摘 | Radman T Ramos R L Brumberg J C | 2009 | Brain Stimulation2009，2，4： | 1 |
| 4 | Adsorption of fluoride from aqueous solution on aluminum-impregnated carbon显示文摘 | Ramos L R Ovalle-Turrubiartes J Sanchez-Castillo M A | 1999 | Carbon1999，37，： | 1 |
| 5 | Ectopic thyroid presenting as a submandibular mass显示文摘 | BERSANETI J A SILVA R D RAMOS R R | 2011 | Head Neck Pathol2011，5，： | 1 |
| 6 | Journal of Chromatography A显示文摘 | BORDAJANDI L R RAMOS J J SANZ J | 2008 | 1186: 312- 3242008，1186，： | 1 |
| 7 | Transverse myelitis affect- ing more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients 显示文摘 | Espinosa G Mendizabal A Minguez S Ramo - Tello C Capellades J Olive A Cervera R | 2010 | Semin Arthritis Rheum2010，39，4： | 1 |
| 8 | Phylogeography of the endangered rosewood Dalbergia nigra (Fabaceae): insights into the evolutionary history and conservation of the Brazilian Atlantic Forest显示文摘 | Ribeiro R A Lemos J P Ramos A C S | 2011 | Heredity2011，106，： | 1 |
| 9 | Characterization of Botrytis cinerea isolates present in Thompson seedless table grapes in the Central Valley of Chile显示文摘 | ESTERIO M MUNOZ G RAMOS C COFRE G ESTEVEZ R SALINAS A AUGER J | 2011 | Plant Dis2011，95，： | 1 |
| 10 | Evaluating the impact of extreme temperature based indices in the 2003 heatwave excessive mortality in Portugal显示文摘 | Trigo R M Ramos A M Nogueirac P J | | 0，，07： | 1 |
| 11 | Con- struction, expression, immunogenicity of the and Schistosoma mansoni P28 glutathione S - transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of salmonella显示文摘 | KHAN C M VILLARREAL RAMOS B PIERCE R J | 1994 | Proc Notl Acad Sci U S A1994，91，11： | 1 |
| 12 | Biomechanical pulping of Agave sisalana显示文摘 | Idarraqa G Ramos J Younq R A | 2001 | Holzforschung2001，55，1： | 1 |
| 13 | Gas dispersion measurements in micro-bubble flotation system 显示文摘 | Garibay P R Ramos M E Rubio J | 2012 | Minerals Engineering2012，26，： | 1 |
| 14 | Fast heterodyne optical phase-lock loop using double quantum well laser diodes 显示文摘 | RAMOS R T SEEDS A J | 1992 | Electronics Letters(S0013-5194)1992，28，1： | 1 |
| 15 | An assessment of anxiety in patients with primary hyperhidrosis before and after endoscopic thoracic sympathicolysis显示文摘 | Ramos R Moya J Morera R | 2006 | Eur J Cardiothorac Surg2006，30，2： | 1 |
| 16 | Isobaric volume and enthalpy recovery of glasses- Ⅱ : a transparent multiparameter theory 显示文摘 | Kovacs A J Aklonis J J Hutchinson J M Ramos A R | 1979 | Journal of Polymer Science: Polymer Physics Edition1979，17，7： | 1 |
| 17 | Plasma fibrinolyticprofile in patients with brain tumors显示文摘 | Sawaya R Ramo O J Glas-Greenwalt P | 1991 | Thromb Haemost1991，65，： | 1 |
| 18 | Adsorption of fluoride from aqueous solution on aluminumqmpregnated carbon 显示文摘 | Leyva R Ramos J Ovalle turrubiartes M Sanchenz-Castillo A | 1999 | Carbon1999，37，4： | 1 |
| 19 | Role of cortical cell type and morphology in sub- and su-prathreshold uniform electric field stimulation显示文摘 | Radman T Ramos R L Brumberg J C | | 0，，04： | 1 |
| 20 | Job Losses,Outsourcing and Relocation:Empirical Evidence Using Microdata显示文摘 | Artis M Ramos R Suriach J | 2006 | Ssrn Electronic Journal2006，，5： | 1 |
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